Does caffeine bind to metal ions?

Kolaylı, Sevgi; Ocak, Miraç; Küçük, Murat; Abbasoğlu, Rza

doi:10.1016/s0308-8146(03)00244-9

Cited by 84 publications

(67 citation statements)

References 27 publications

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“…Our second attempt to impose charge to caffeine was trying to complex it with metal ions. Although such complexes are described in the literature [18], the addition of Zn 21 and Ca 21 to the running buffer was not effective. However, another kind of complex was investigated: a pcomplex with an ionic species.…”

Section: Introductionmentioning

confidence: 88%

Determination of caffeine in coffee products by dynamic complexation with 3,4‐dimethoxycinnamate and separation by CZE

Nogueira

Lago

2007

Electrophoresis

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A method based on the formation of pi-complexes with chlorogenate-like species was proposed for the determination of caffeine in regular (nondecaffeinated) and decaffeinated coffee. Both caffeate and 3,4-dimethoxycinnamate were able to transform caffeine--a neutral species in aqueous solutions--into an anionic species. The usage of 3,4-dimethoxycinnamate in the running electrolyte is advantageous, because of its greater chemical stability and the improved resolution of the peaks of caffeine, theobromine, and theophylline. Negative peaks were registered with a capacitively coupled contactless conductivity detector when solutions of these alkylxanthines were analyzed with a BGE composed of 20 mmol/L 3,4-dimethoxycinnamic acid and pH adjusted to 8.5 with Tris. This behavior was expected, because the complex is larger and thus should move slower than the free anion. Caffeine was determined in ground and instant coffee with precision and accuracy that meet Brazilian norms about such products. The LOD was estimated as 33 mg/L, which corresponds to 0.8 and 0.3 mg of caffeine per gram of dry instant coffee and ground coffee, respectively. For the case of decaffeinated coffee, ten times preconcentration with dichloromethane was carried out to allow the quantitation of caffeine, which should not exceed the concentration of 1 mg/g in dry matter.

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Section: Introductionmentioning

confidence: 88%

Determination of caffeine in coffee products by dynamic complexation with 3,4‐dimethoxycinnamate and separation by CZE

Nogueira

Lago

2007

Electrophoresis

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“…Caffeine and other methylxanthines are used in clinical medicines as diuretics, analgesics, muscle relaxants and can aid in the treatment of brain disorders such as headaches and Parkinson's diseases (Kolayli et al, 2004). In humans, low and average doses of caffeine produce increase alertness and positive effects on the myocardium, while high doses causes caffeine dependency with a wide range of unpleasant physical and mental conditions such as nervousness, irritability, restlessness, insomnia, headache and heart palpitations (Lanch et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Attenuating Potential of Trévo Dietary Supplement on Caffeine Induced Sperm Toxicities in Albino Rats

Ekaluo¹,

Uno²,

Ekpo³

et al. 2015

Asian J. of Clinical Nutrition

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The attenuating potential of Trévo Dietary Supplement (TDS), a multi-herbal health drink containing 174 ingredients on caffeine-induced sperm toxicities was studied on albino rats. Thirty healthy male albino rats of 12 weeks old were divided into five groups with six rats in each group using a Completely Randomized Design (CRD). The experimental animals were treated with combinations of caffeine and TDS orally. The treatment lasted for 65 days. Results indicated statistically significant (p<0.05) decreases in weight of testes and epididymis, epididymal sperm viability, motility and count in caffeine treated rats. There was a concomitant increase in sperm head abnormalities in caffeine treated rats. However, TDS effectively attenuated the caffeine induced sperm toxicities in albino rat models in a dose dependent manner.

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“…Caffeine has been the subject of extensive research for its occurrence in nature and its long history of use [21]. It is a naturally occurring alkaloid [22] which is found in the leaves, seeds or fruits of over 63 plants species worldwide [1], [21].…”

Section: Introductionmentioning

confidence: 99%

“…It is a naturally occurring alkaloid [22] which is found in the leaves, seeds or fruits of over 63 plants species worldwide [1], [21]. The most common sources of caffeine are coffee [12], [16], [21], [23], cocoa beans, cola nuts and tea leaves and the worldwide consumption of products derived from these natural materials means that caffeine is one of the most popular and commonly consumed drugs in the world [21].…”

Section: Introductionmentioning

confidence: 99%

Determination of Caffeine Content and Antioxidant Activity of Coffee

Gebeyehu¹

2015

AJAC

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Attempt has been made to look into caffeine contents and antioxidant activity of coffee grown at Wembera, Goncha, Zegie, and Burie localities of North-West Ethiopia. The caffeine content of the extracts in % w/w has been found to be 1.53 ± 0.003 for Wembera coffee, 1.41 ± 0.040 for Goncha coffee, 1.29 ± 0.033 for Zegie coffee and 0.97 ± 0.049 for Burie coffee. The antioxidant activities of the coffee extracts were measured by using ferric reducing power assay and Rancimat assay. Ferric reducing power assay was used to measure the total antioxidant power of water soluble components of coffee and is expressed as ascorbic acid equivalent antioxidant capacity in milligram per gram of the dried coffee samples. The ferric reducing power values of the extracts were 9.532 ± 0.201, 9.159 ± 0.441, 8.955 ± 0.180, 6.751 ± 0.284 for Wembera, Burie, Goncha and Zegie coffees, respectively. The Rancimat assay was also used to measure antioxidant activity of lipid soluble portions of coffee extracts using sunflower oil as the oxidizable substrate. It was found that all the coffee extracts improved the oxidative stability of sunflower oil. The protection factors were 1.36 ± 0.027, 1.31 ± 0.027, 1.26 ± 0.069 and 1.17 ± 0.015 for Wembera, Burie, Goncha and Zegie coffees respectively. Based on these results, it is suggested that Wembera coffee has the higher caffeine content and antioxidant activities than Burie, Goncha and Zegie coffee varieties.

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Does caffeine bind to metal ions?

Cited by 84 publications

References 27 publications

Determination of caffeine in coffee products by dynamic complexation with 3,4‐dimethoxycinnamate and separation by CZE

Determination of caffeine in coffee products by dynamic complexation with 3,4‐dimethoxycinnamate and separation by CZE

Attenuating Potential of Trévo Dietary Supplement on Caffeine Induced Sperm Toxicities in Albino Rats

Determination of Caffeine Content and Antioxidant Activity of Coffee

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