2014
DOI: 10.1097/mpg.0000000000000263
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Does Calretinin Immunohistochemistry Reduce Inconclusive Diagnosis in Rectal Biopsies for Hirschsprung Disease?

Abstract: Many difficulties occur during the evaluation of rectal biopsies for the diagnosis of Hirschsprung disease. We investigated whether the introduction of calretinin (CR) immunohistochemistry in a diagnostic panel could decrease the rate of inconclusive results. Data from 82 patients undergoing rectal biopsies before and after CR introduction were analyzed. Inconclusive results were obtained in 17 of 45 rectal biopsies (37.8%) in the series of cases before CR introduction and in 5 of 42 rectal biopsies (11.9%) in… Show more

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Cited by 18 publications
(21 citation statements)
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“…There is a trend to a lower rate of non-conclusive results using ACE ? Calretinin staining that could be proven with a larger group of patients, as it has been found by other authors [7].…”
Section: Discussionmentioning
confidence: 64%
See 3 more Smart Citations
“…There is a trend to a lower rate of non-conclusive results using ACE ? Calretinin staining that could be proven with a larger group of patients, as it has been found by other authors [7].…”
Section: Discussionmentioning
confidence: 64%
“…The rate of non-conclusive results varies from one to another report (11-37.8 %) [5][6][7][8][9]. The most frequent cause of non-conclusive results is an inadequate sample, being the most common ones the lack of submucosa and the presence of squamous epithelium in the specimen [13,17,20].…”
Section: Discussionmentioning
confidence: 95%
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“…2,12 Recently, several immunohistochemical markers have been used in the diagnosis of intestinal dysganglionoses, particularly for Hirschsprung's disease. [24][25][26][27][28] Calretinin is a vitamin D-dependent 29-kDa protein that binds to calcium and has an important role as a sensor and modulator of calcium ions. 29 The absence of this protein leads to the accumulation of these ions in the cytoplasm of nerve cells, promoting hyperexcitability and neurodegeneration.…”
mentioning
confidence: 99%