Does cantharides blister fluid provide access to the peripheral compartment?

Schäfer‐Korting, Monika; Körting, Hans Christian; Hiemstra, S; Mutschler, E.

doi:10.1007/bf00613614

Cited by 16 publications

(14 citation statements)

References 12 publications

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“…Therefore, there are many available data on the penetration of various antibiotics into cantharis-or suction-induced skin blister fluid (9,17,19,23,30,60,71,111,137,138,146 ). These studies were justified by the notion that "skin blister fluid levels are closer to the biophase than blood" (138).…”

Section: Methods For Studies Of Target Site Drug Distribution In Antimentioning

confidence: 99%

Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue

Müller

Peña

Derendorf

2004

Antimicrob Agents Chemother

240

201

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Section: Methods For Studies Of Target Site Drug Distribution In Antimentioning

confidence: 99%

Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue

Müller

Peña

Derendorf

2004

Antimicrob Agents Chemother

240

201

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“…How ever, blisters contain an inflammatory exudate that does not reflect hormone levels found in normal, noninflamed tissue. 104 Furthermore, blister fluid concentrations of hormones and drug molecules reach equilibrium with their corresponding circulating levels after approximately 2 h, which is an important limitation in investigations of very rapid perturbations in cortisol equilibrium. 105 Cell-based bioassays Cell-based bioassays have been developed in the past decade for the quantification of glucocorticoid bioavailability in human serum.…”

Section: Extracellular Tissue Techniquesmentioning

confidence: 99%

Regulation of cortisol bioavailability—effects on hormone measurement and action

2012

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Routine assessment of the hypothalamic-pituitary-adrenal axis relies on the measurement of total serum cortisol levels. However, most cortisol in serum is bound to corticosteroid-binding globulin (CBG) and albumin, and changes in the structure or circulating levels of binding proteins markedly affect measured total serum cortisol levels. Furthermore, high-affinity binding to CBG is predicted to affect the availability of cortisol for the glucocorticoid receptor. CBG is a substrate for activated neutrophil elastase, which cleaves the binding protein and results in the release of cortisol at sites of inflammation, enhancing its tissue-specific anti-inflammatory effects. Further tissue-specific modulation of cortisol availability is conferred by corticosteroid 11β-dehydrogenase. Direct assessment of tissue levels of bioavailable cortisol is not clinically practicable and measurement of total serum cortisol levels is of limited value in clinical conditions that alter prereceptor glucocorticoid bioavailability. Bioavailable cortisol can, however, be measured indirectly at systemic, extracellular tissue and cell levels, using novel techniques that have provided new insight into the transport, metabolism and biological action of glucocorticoids. A more physiologically informative approach is, therefore, now possible in the assessment of the hypothalamic-pituitary-adrenal axis, which could prove useful in clinical practice.

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“…Thus, ofloxacin levels in serum and blister fluid after repeated drug intake are of particular interest. It was the aim of this study to compare ofloxacin levels in the fluids of noninflamed tissues (suction blister fluid [SBF]) (7,20) and inflamed tissues (CBF) (1,16,19) After completing suction blistering, the volunteers received the final ofloxacin dose together with a standardized breakfast. Blood samples for serum and saliva were collected prior to and 0.25, 0.5, 1, 1.5, 2, 3, 6, 12, 27, and 36 h after drug administration.…”

mentioning

confidence: 99%

Multiple-dose pharmacokinetics of ofloxacin in serum, saliva, and skin blister fluid of healthy volunteers

Warlich

Körting

Schäfer‐Korting

et al. 1990

Antimicrob Agents Chemother

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The pharmacokinetics of ofloxacin were determined in six healthy volunteers after oral administration of 200 mg twice daily for 3.5 days. To study the pharmacokinetic behavior at the target site in bacterial infection of the skin, drug concentrations were determined in suction blister fluid (SBF) Ofloxacin is a fluorinated quinolone exhibiting a marked bactericidal effect by inhibiting DNA gyrase (13, 21). Ofloxacin is active against a wide spectrum of microorganisms, including gram-positive bacteria (11,23, 24). Moreover, it is one of the first drugs allowing oral treatment of infections caused by Pseudomonas aeruginosa (4).Ofloxacin shows therapeutically valuable pharmacokinetic properties such as a medium-range elimination half-life, almost complete bioavailability, negligible metabolism, and predominant renal excretion (9, 11).Since the target sites of antibiotics are predominantly located in the tissues, suitable tissue penetration is also mandatory. Lockley et al. (8) determined ofloxacin cantharides blister fluid (CBF) levels after a single oral dose of 600 mg. Kalager and co-workers (6) used the suction blister method to compare tissue levels in the fasting and nonfasting state (ofloxacin, 300 mg orally).In general, however, ofloxacin is not administered as a single dose but is administered repeatedly for 7 to 10 days. Thus, ofloxacin levels in serum and blister fluid after repeated drug intake are of particular interest. It was the aim of this study to compare ofloxacin levels in the fluids of noninflamed tissues (suction blister fluid [SBF]) (7,20) of an allergy to quinolone carboxylic acids. The study protocol was approved by the local ethics committee, and written informed consent was obtained from each volunteer. During the investigation period, the intake of other drugs and the ingestion of alcohol or caffeine were not allowed.

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Does cantharides blister fluid provide access to the peripheral compartment?

Cited by 16 publications

References 12 publications

Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue

Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue

Regulation of cortisol bioavailability—effects on hormone measurement and action

Multiple-dose pharmacokinetics of ofloxacin in serum, saliva, and skin blister fluid of healthy volunteers

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