Does Cardiac Function Affect Cerebral Blood Flow Regulation?

Abstract

Many previous studies indicate that heart failure (HF) increases the risk of cognitive dysfunction and stroke, showing the logic that several physiological factors associated with cardiac dysfunctions affect homeostasis in the cerebral circulation. In the chronic process of HF patients, it is suggested that reduced cerebral blood flow (CBF) and abnormal auto-regulation might result in impaired perfusion, metabolic insufficiency, and regional or global structural deteriorations in the brain. However, the mechanism underlying HF-induced brain disease remains unclear. Cardiac dysfunction in patients with HF or HF-induced several physiological abnormalities may cause brain dysfunction. Possible physiological factors should be considered for future studies to prevent brain disease as well as cardiovascular dysfunction in patients with HF.

The value of cardiopulmonary comorbidity in patients with acute large vessel occlusion stroke undergoing endovascular thrombectomy: a retrospective, observational cohort study

“…Although ALVOS patients in the CC group have more AF, fewer stroke onset was caused by cardioembolism. It is speculated that long-term chronic cardiopulmonary dysfunction may result in an increase in the proportion of large-vessel atherosclerosis infarction.Chronic heart failure reduced cerebral blood flow and abnormal auto-regulation might result in impaired perfusion and arterial stiffness in the brain [ 25 , 26 ]. Previous study showed poor pulmonary dysfunction could cause cerebral small vessel diseases [ 21 , 27 ].…”

Cardiovascular Comorbidities in Relation to the Functional Status and Vitamin D Levels in Elderly Patients with Dementia

“…Cardiovascular comorbidities have been proven to be highly correlated with pathological changes in cerebral circulation, with some researchers emphasizing a common factor, namely, central arterial stiffening [ 37 , 38 ], with up to 50% of patients diagnosed with heart failure having an associated cognitive dysfunction. Although some compensatory mechanisms were described to explain cerebral blood flow autoregulation, heart dysfunction results in impaired perfusion, metabolic insufficiency, and regional or global structural deterioration in the brain.…”

“…Although some compensatory mechanisms were described to explain cerebral blood flow autoregulation, heart dysfunction results in impaired perfusion, metabolic insufficiency, and regional or global structural deterioration in the brain. Moreover, recent research showed that the vascular bed of the external carotid artery is an important buffering mechanism for preventing over- or hypo-perfusion in the intracranial cerebral anterior artery due to certain cardiovascular conditions [ 37 , 39 , 40 ]. The circle of Willis is the primary collateral system protecting the brain from ischemia when occlusions occur in the intracranial arteries, but the arteries in the circle of Willis system are susceptible to atherosclerosis and aneurysms, which highly influence its hemodynamics [ 39 , 40 ].…”

Possibility of correction of cerebral blood flow disorders and central nervous system damage with citicoline in patients with coronary artery disease in combination with COVID-19

“…Білок вірусу ORF8 може зв'язуватися з порфірином, а білок ORF10 здатний уразити 1β-ланцюг гемоглобіну та зв'язуватися з гемом. Такі нюанси морфології потенційно впливають на механізм контамінації вірусу, а також різноманітний перебіг хвороби в дорослих і дітей через іншу будову гемоглобіну [21]. Гіперкоагуляція у хворих на COVID-19 часто розвивається на тлі тяжкого перебігу та може поєднуватися зі схильністю до геморагій.…”

“…Частим ускладненням цього стану є розвиток тромботичних ускладнень (ішемічний інсульт, тромбоемболія легеневої артерії). Крім того, при COVID-19 збільшується ендотеліальна дисфункція, що пояснює основні її системні прояви -гіперкоагуляцію та тромботичні ускладнення, котрі є причиною цереброваскулярних ускладнень, особливо у хворих із наявними в анамнезі судинними чинниками ризику: гіпертонічною хворобою, серцево-судинними захворюваннями та цукровим діабетом [20][21][22].…”