religious participation has repeatedly been shown to have a surprisingly strong inverse association with cigarette smoking [1]. The report of Hofstetter et al. in this journal confirms this association in an immigrant population [2]. We hypothesized further that this association might become weaker with greater acculturation and education in an immigrant population.In a national health survey [1], 5,088 Mexican Americans aged 17 years and over had data on frequency of attendance at religious services (FARS), smoking, education, place of birth, language spoken at home, indicators of acculturation. In men and women combined, among the 1750 speaking English at home, the prevalence of smoking was strongly related to FARS (never 31.5%, [weekly 6.7%, P \ 0.01). This was also true among the 3079 who spoke Spanish at home (never 29.4, [weekly 7.9%, P \ 0.01). The same was true for men and women and those aged 17-24 years. Logistic regression analysis with smoking as dependent variable confirmed the lack of interaction between FARS and language spoken at home (men P = 0.37, women P = 0.43, all P = 0.44).In men and women combined, among the 2218 born in Mexico, the prevalence of smoking was strongly related to FARS (never 29.0%, [weekly 4.5%, P \ 0.01). This was also true among the 2505 born in the US (never 31.5, [weekly 10.0%, P \ 0.01). The same was true for men and those aged 17-24 years. In women, the association between attendance and smoking was statistically significant in US born (P \ 0.01) but not foreign-born (P = 0.17). However, logistic regression analysis with smoking as dependent variable detected no significant interaction between FARS and natality in any group (men P = 0.50, women P = 0.34, all P = 0.40).In men and women combined, among the 1815 with 12 or more years of education, the prevalence of smoking was strongly related to FARS (never 25.3%, [weekly 4.4%, P \ 0.01). This was also true among the 3253 with fewer than 12 years of education (never 33.5, [weekly 10.4%, P \ 0.01). The same was true for men and women. Logistic regression analysis with smoking as dependent variable confirmed the lack of interaction between FARS and education level (men P = 0.89, women P = 0.25, all P = 0.70).These findings suggest that the apparent protective effect of religious participation to produce tobacco avoidance does not diminish among Mexican immigrants to the US as they and their descendents become acculturated and more educated. These analyses should be replicated in other immigrant populations.