Does Cigarette Smoking Lead to the Subsequent Development of Leukemia?

Severson, Richard K.; Linet, Martha S.

doi:10.1001/archinte.1993.00410040005001

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…The overall prevalence rate of cigarette use by American adults is 25% 32. Some have proposed a link between smoking and the hematoproliferative malignancies, and alcohol's role as a carcinogen has been documented 33–36. Although it is speculative, cigarette smoking and alcohol use by the participants may account for the observation that their mean age is nearly 1 decade less than the usual age of CML onset.…”

Section: Discussionmentioning

confidence: 99%

Depression, cigarette smoking, and hematopoietic stem cell transplantation outcome

Chang

Orav

McNamara

et al. 2004

Cancer

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BACKGROUND The relationships between psychological and behavioral variables and patient outcomes after hematopoietic stem cell transplantation (HSCT) are not known definitively but have great potential importance, since this lifesaving procedure is used increasingly to treat a variety of malignancies. The objective of this study was to evaluate psychosocial predictors of long‐term survival and disease recurrence after patients underwent allogeneic HSCT for chronic myelogenous leukemia (CML). METHODS In this prospective cohort study, 114 adults were admitted for allogeneic HSCT to the Brigham and Women's Hospital between July, 1997 and January, 2002. The median follow‐up was 882 days, and serial measures were taken for mood and substance use 6 months and 12 months posttransplantation. RESULTS With a 93% participation rate by all potentially eligible patients and with < 3% of patients loss to follow‐up, univariate predictors of long‐term survival and recurrence were identified. Cox proportional hazards regression models for survival and recurrence were developed. Depressive symptoms, as measured by the most recent Beck Depression Inventory (BDI), increased the risk of death by 7% for each point increase in the BDI score (P = 0.006). Fourteen of 17 patients who developed recurrent disease were cigarette smokers with an average of 22.3 pack‐years. For each pack‐year of cigarette smoking, the risk of recurrence increased by 1.7% (P = 0.01). CONCLUSIONS This study assessed the role of psychosocial variables prospectively among a clinically homogeneous but representative cohort of patients who underwent allogeneic HSCT. Although additional confirmatory studies are pending, it appears that depressive symptoms posttransplantation and cigarette smoking prior to transplantation affect outcomes adversely and may represent opportunities to improve the morbidity and mortality associated with HSCT for patients with CML. Cancer 2004. © 2004 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Depression, cigarette smoking, and hematopoietic stem cell transplantation outcome

Chang

Orav

McNamara

et al. 2004

Cancer

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“…Some studies of CML have reported a dose-response effect according to the duration and/or intensity of smoking, while others revealed no such effect [19,20]. Seven studies suggest a positive correlation between cigarette smoking and CML [20][21][22][23][24][25][26]. Furthermore, there are controversial reports reflective of the complex effects of smoking on the human body, as well as the heterogeneity of the parameters used among different studies.…”

Section: Introductionmentioning

confidence: 99%

Relationship between cigarette smoking and risk of chronic myeloid leukaemia: a meta-analysis of epidemiological studies

et al. 2016

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Segregation analysis of smoking‐associated malignancies: Evidence for mendelian inheritance

et al. 1994

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Tobacco consumption is an established risk factor for cancer at a number of sites: oral cavity, esophagus, nasopharynx, lung, larynx, pancreas, bladder, kidney, and uterine cervix. These sites also demonstrate familial aggregation. To determine if evidence exists for a major gene controlling susceptibility to smoking-associated cancers, maximum likelihood segregation analyses were performed on 337 families (3,276 individuals) ascertained through a deceased lung cancer proband. Models were fitted that allowed for personal tobacco use and variable age of onset. The hypotheses of environmental transmission and no major gene were rejected (P < 0.005), but none of the Mendelian models could be distinguished. According to Akaike's Information Criterion, Mendelian dominant inheritance of an allele that produces cancer at an earlier age of onset provided the best fit to the data. The model suggests that 62% of the population are susceptible, and that the mean age-of-onset differs for men and women: at the mean level of tobacco exposure, female gene carriers are affected, on average, 24 years earlier than non-carriers (77 vs. 101), while in males the difference was 20 years (71 vs. 91). These findings extend our earlier observations on the genetic epidemiology of lung cancer and suggest that Mendelian factors may influence the risk of cancers that are known to be smoking associated.

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Does Cigarette Smoking Lead to the Subsequent Development of Leukemia?

Cited by 5 publications

References 24 publications

Depression, cigarette smoking, and hematopoietic stem cell transplantation outcome

Depression, cigarette smoking, and hematopoietic stem cell transplantation outcome

Relationship between cigarette smoking and risk of chronic myeloid leukaemia: a meta-analysis of epidemiological studies

Segregation analysis of smoking‐associated malignancies: Evidence for mendelian inheritance

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