Does consanguinity lead to decreased incidence of breast cancer?

Bener, Abdülbari; Ayoubi, Hanadi Rafii El; Ali, Awab I; Al-Kubaisi, Aisha; Al-Sulaiti, Haya

doi:10.1016/j.canep.2010.04.004

Cited by 34 publications

(28 citation statements)

References 15 publications

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“…However, the difference between the two groups is not statistically significant (p>0.001), suggesting that inbreeding may have a small protective effect against breast cancer that could have been detected with a larger study sample. This finding is similar to the result of previous population-based studies conducted in women with breast cancer (Denic et al, 2001;Bener et al, 2010) showing that the parental consanguinity was more frequent in women without breast cancer than in those with cancer, and that the coefficient of inbreeding was lower in breast cancer patients.…”

Section: Discussionsupporting

confidence: 82%

“…In fact, consanguinity which increases the chances of homozygosity, was linked to an increased risk of breast RESEARCH ARTICLE cancer by many authors (Simpson et al, 1981;Shami et al, 1991;Rudan et al, 1999;Liede et al, 2002;Denic et al, 2003;Denic et al, 2007). However, studies conducted in other populations have shown that consanguinity does not affect, or may be protective for breast cancer risk (Denic et al, 2001;Denix et al, 2005;Bener et al, 2010). This suggests that the effect of inbreeding on cancer risk may differ for different tumours, for the same tumour and may vary between populations.…”

Section: Introductionmentioning

confidence: 99%

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Low Level of Consanguinity in Moroccan Families at High Risk of Breast Cancer

Elalaoui¹,

Jaouad²,

Laarabi³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Breast cancer is worldwide the most common cancer in women and is a major public health problem. Genes with high or low penetrance are now clearly implicated in the onset of breast cancer, mostly the BRCA genes. All women in families at high risk of breast cancer do not develop tumours, even when they carry the familial mutation, suggesting the existence of genetic and environmental protective factors. Several studies have shown that consanguinity is linked to a decreased or an increased risk of breast cancer, but to the best of our knowledge, there is no study concerning the association between consanguinity and the occurrence of tumours in women with high risk of breast cancer. The objective of this study was to examine whether parental consanguinity in families with genetic predisposition to breast cancer affect the risk of siblings for having this cancer. Materials and Methods: Over a six-year period, 72 different patients with a histological diagnosis of breast or ovarian cancer from 42 families were recruited for genetic counselling to the Department of Medical Genetics, Rabat. Consanguinity rate was determined in cases and compared to the consanguinity rate in the Moroccan general population. Results: Consanguinity rates were 9.72% in patients and 15.3% in controls, but the difference was statistically not significant (p>0.001) and the mean coefficient of consanguinity was lower in breast cancer patients (0.0034) than in controls (0.0065). Conclusions: Despite the relatively small sample size of the current study, our results suggest that parental consanguinity in Moroccan women might not be associated with an altered risk of breast cancer. Large scale studies should be carried out to confirm our results and to develop public health programs.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Low Level of Consanguinity in Moroccan Families at High Risk of Breast Cancer

Elalaoui¹,

Jaouad²,

Laarabi³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…ROPN1L was a potential novel candidate identified in a GWA study for breast cancer susceptibility (Sehrawat et al, 2011), which suggested that BMI and cancer might share genetic components. Interestingly, the family history of breast cancer and BMI are highly associated with breast cancer (Bener et al, 2010). In addition, it has been shown that BMI, obesity and cancer may share genetic components (Brennan et al, 2009;Lewis et al, 2010;Lurie et al, 2011;Tang et al, 2011).…”

Section: Discussionmentioning

confidence: 98%

A novel locus for body mass index on 5p15.2: A meta-analysis of two genome-wide association studies

Wang

Zheng

et al. 2012

Gene

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“…Consanguinity might be also an equivocal risk-modifying factor [21,22]. Indeed, the Lebanese population has a relatively high rate of consanguinity (around 15–20 %), and association studies on consanguinity and breast cancer, and the frequency of BRCA 1 and BRCA2 in highly consanguineous populations pointed that consanguinity might lead to decreased incidence of breast cancer [23].…”

Section: Discussionmentioning

confidence: 99%

Prevalance of BRCA1 and BRCA2 mutations in familial breast cancer patients in Lebanon

Jalkh

Nassar-Slaba

Chouery

et al. 2012

Hered Cancer Clin Pract

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Breast cancer is the most prevalent malignancy in women in Western countries, currently accounting for one third of all female cancers. Familial aggregation is thought to account for 5–10 % of all BC cases, and germline mutations in BRCA1 and BRCA2 account for less of the half of these inherited cases. In Lebanon, breast cancer represents the principal death-causing malignancy among women, with 50 % of the cases diagnosed before the age of 50 years. In order to study BRCA1/2 mutation spectra in the Lebanese population, 72 unrelated patients with a reported family history of breast and/or ovarian cancers or with an early onset breast cancer were tested. Fluorescent direct sequencing of the entire coding region and intronic sequences flanking each exon was performed. A total of 38 BRCA1 and 40 BRCA2 sequence variants were found. Seventeen of them were novel. Seven confirmed deleterious mutations were identified in 9 subjects providing a frequency of mutations of 12.5 %. Fifteen variants were considered of unknown clinical significance according to BIC and UMD-BRCA1/BRCA2 databases. In conclusion, this study represents the first evaluation of the deleterious and unclassified genetic variants in the BRCA1/2 genes found in a Lebanese population with a relatively high risk of breast cancer.

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Does consanguinity lead to decreased incidence of breast cancer?

Cited by 34 publications

References 15 publications

Low Level of Consanguinity in Moroccan Families at High Risk of Breast Cancer

Low Level of Consanguinity in Moroccan Families at High Risk of Breast Cancer

A novel locus for body mass index on 5p15.2: A meta-analysis of two genome-wide association studies

Prevalance of BRCA1 and BRCA2 mutations in familial breast cancer patients in Lebanon

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