Does Creatine Supplementation Affect Renal Function in Patients with Peripheral Artery Disease? A Randomized, Double Blind, Placebo-controlled, Clinical Trial

Domingues, Wagner Jorge Ribeiro; Ritti‐Dias, Raphael Mendes; Cucato, Gabriel Grizzo; Wolosker, Nelson; Zerati, Antônio Eduardo; Puech-Leão, Pedro; Nunhes, Pollyana Mayara; Moliterno, André Alberto; Avelar, Ademar

doi:10.1016/j.avsg.2019.07.008

Cited by 5 publications

(5 citation statements)

References 34 publications

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“…Some studies have reported that the compound can have adverse effects on Kidneys function (Thorsteinsdottir, 2006;Taner et al, 2011). On the other hand, other researchers have not determined the risk of renal damage, and episodes of nephrotoxicity are rare in healthy patients supplemented with Creatine (Gualano et al, 2008;Gualano et al, 2011;Domingues et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Impact Assessment of Creatine on Many Physiological and Biochemical Scales in Male Rabbits

Alwan¹,

AL-MASOUDI²,

Kudayer³

2022

MINAR Journal

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Creatine is a substance found naturally in body tissues, especially in the muscles and brain. Creatine is found in the diet, especially in seafood and red meat, and is commonly used to increase muscle mass and improve exercise performance in humans. This research was design to evaluate the effects of creatine administration on many physiological and biochemical parameters. In the method design, 24 mature adult male rabbits are divided at random into four groups as the following: G1 (Group of control): six mature adult of male rabbits orally administered distilled H2O (1ml/animal) by gavage daily, G2 mature adult of male rabbits were orally administration creatine monohydrate (1ml/kg BW) by gavage daily. G 3 mature adult of male rabbits were orally administration creatine monohydrate (2ml/kg BW) by gavage daily. While G4 adult male rabbits were orally administration creatine monohydrate (3ml/kg BW). After 30-days of administration, the rabbits were anaesthetized and blood samples were collected for determination thyroid hormones, liver enzymes, lipid profiles and kidney function (determined by urea, creatinine levels) and serum total protein levels, in the results, the groups that received 1, 2 and 3 ml of creatinine significantly increased but more over increased in group treated with 3 ml of creatinine in all studied parameters such as T4 hormones, liver enzymes, urea, creatinine levels and all lipid profile except TSH, T3, HDL, total protein concentration decreased significantly compared to the control group. In conclusions, the creatine has harmful effect on biochemical and physiological parameters in the creatine-treated group (3ml). In the conclusion that an adverse effect of creatine on the functions of the thyroid gland, liver and kidneys increases in these organs with increase doses.

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Section: Discussionmentioning

confidence: 99%

Impact Assessment of Creatine on Many Physiological and Biochemical Scales in Male Rabbits

Alwan¹,

AL-MASOUDI²,

Kudayer³

2022

MINAR Journal

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“…Our study presents some limitations. Although we analyzed the amount of creatine in the blood [33], we did not measure the content of creatine in the muscle and, thus, the impact of supplementation on the calf muscle was not determined. Our findings are restricted to the time of supplementation and the dosage of creatine used in this study.…”

Section: Discussionmentioning

confidence: 99%

Effect of Creatine Supplementation on Functional Capacity and Muscle Oxygen Saturation in Patients with Symptomatic Peripheral Arterial Disease: A Pilot Study of a Randomized, Double-Blind Placebo-Controlled Clinical Trial

et al. 2021

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The aim of the study was to verify the effects of creatine (Cr) supplementation on functional capacity (walking capacity; primary outcome) and calf muscle oxygen saturation (StO2) (secondary outcome) in symptomatic peripheral arterial disease (PAD) patients. Twenty-nine patients, of both sexes, were randomized (1:1) in a double-blind manner for administration of placebo (PLA, n = 15) or creatine monohydrate (Cr, n = 14). The supplementation protocol consisted of 20 g/day for 1 week divided into four equal doses (loading phase), followed by single daily doses of 5 g in the subsequent 7 weeks (maintenance phase). Functional capacity (total walking distance) was assessed by the 6 min walk test, and calf muscle StO2 was assessed through near infrared spectroscopy. The measurements were collected before and after loading and after the maintenance phase. The level of significance was p < 0.05. No significant differences were found for function capacity (total walking distance (PLA: pre 389 ± 123 m vs. post loading 413 ± 131 m vs. post maintenance 382 ± 99 m; Cr: pre 373 ± 149 m vs. post loading 390 ± 115 m vs. post maintenance 369 ± 115 m, p = 0.170) and the calf muscle StO2 parameters (p > 0.05). Short- and long-term Cr supplementation does not influence functional capacity and calf muscle StO2 parameters in patients with symptomatic PAD.

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“…Several longitudinal, controlled studies in humans investigated the effects of creatine supplementation in kidney function among different populations [ 5 , 38 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ]. To provide a comprehensive overview, Table 3 and Table 4 summarize the main results of studies conducted in both healthy and clinical populations, respectively.…”

Section: Creatine Supplementation and Kidney Functionmentioning

confidence: 99%

“… Effects of creatine supplementation on creatine metabolism and kidney function parameters, based on randomized controlled trials in humans [ 5 , 38 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ]. Oral intake of creatine increases total creatine body pool (particularly in skeletal muscle), also leading to an increase (in some cases) in serum Crn from the spontaneous (i.e., non-enzymatically) and irreversible degradation of creatine into Crn, at a rate of ~2% of the total body pool per day.…”

Section: Figurementioning

confidence: 99%

Is It Time for a Requiem for Creatine Supplementation-Induced Kidney Failure? A Narrative Review

et al. 2023

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Creatine has become one of the most popular dietary supplements among a wide range of healthy and clinical populations. However, its potential adverse effects on kidney health are still a matter of concern. This is a narrative review of the effects of creatine supplementation on kidney function. Despite a few case reports and animal studies suggesting that creatine may impair kidney function, clinical trials with controlled designs do not support this claim. Creatine supplementation may increase serum creatinine (Crn) concentration for some individuals, but it does not necessarily indicate kidney dysfunction, as creatine is spontaneously converted into Crn. Based on studies assessing kidney function using reliable methods, creatine supplements have been shown to be safe for human consumption. Further studies with people who have pre-existing kidney disease remain necessary.

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Does Creatine Supplementation Affect Renal Function in Patients with Peripheral Artery Disease? A Randomized, Double Blind, Placebo-controlled, Clinical Trial

Abstract: Ademar (2020) Does creatine supplementation affect renal function in patients with peripheral artery disease? A randomized, double blind, placebo-controlled, clinical trial. Annals of Vascular Surgery, 63. pp. 45-52.

Cited by 5 publications

References 34 publications

Impact Assessment of Creatine on Many Physiological and Biochemical Scales in Male Rabbits

Impact Assessment of Creatine on Many Physiological and Biochemical Scales in Male Rabbits

Effect of Creatine Supplementation on Functional Capacity and Muscle Oxygen Saturation in Patients with Symptomatic Peripheral Arterial Disease: A Pilot Study of a Randomized, Double-Blind Placebo-Controlled Clinical Trial

Is It Time for a Requiem for Creatine Supplementation-Induced Kidney Failure? A Narrative Review

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