Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer?

Söderberg‐Nauclér, Cecilia

doi:10.1111/j.1365-2796.2006.01618.x

Cited by 295 publications

(280 citation statements)

References 273 publications

(309 reference statements)

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“…Adequate cell-mediated immunity is important for maintaining the virus in this chronic state (14,15). Importantly, CMV has been linked to inflammatory processes, cardiovascular disease, cognitive outcomes, and Alzheimer's disease (11,(16)(17)(18)(19)(20). For these reasons, it is important to examine the prevalence of CMV at various life stages within diverse socioeconomic and racial groups.…”

Section: Introductionmentioning

confidence: 99%

Socioeconomic disparities in the seroprevalence of cytomegalovirus infection in the US population: NHANES III

2008

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SummaryThere is a strong relationship between socioeconomic status (SES) and health outcomes in the U.S, though the mechanisms are poorly understood. Increasing evidence points to links between lifelong exposure to infectious disease and subsequent chronic disease. Exposure and susceptibility to infections may be one way SES affects long-term health, though little populationbased research to date has examined social patterning of infections in the U.S. This paper tests the relationship between income, education, race/ethnicity and seroprevalence of cytomegalovirus (CMV) infection at different ages in a representative sample of the U.S. population, and tests potential mediators for these relationships. The study finds significant racial and socioeconomic disparities in CMV seroprevalence beginning at early ages and persisting into middle age. Potential exposures do not explain the relationship between socioeconomic status and CMV positivity. Because reactivation of latent CMV infections may contribute to chronic disease and immune decline later in life, future research should determine the exposure or susceptibility pathways responsible for these disparities in the prevalence of CMV infection.

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Section: Introductionmentioning

confidence: 99%

Socioeconomic disparities in the seroprevalence of cytomegalovirus infection in the US population: NHANES III

2008

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“…In recent years, subclinical active HCMV infection has been detected in patients with autoimmune disorders, including rheumatoid arthritis, psoriasis, systemic lupus erythematosus, ulcerative colitis, and Crohn's disease (1). HCMV infection has also been reported in patients with vasculitides.…”

mentioning

confidence: 99%

Generalized Wegener's granulomatosis in an immunocompetent adult after cytomegalovirus mononucleosis and bacterial urinary tract infection

Varani¹,

Mastroianni²,

Frascaroli³

et al. 2009

Arthritis & Rheumatism

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Human cytomegalovirus (HCMV) is frequently detected in autoimmune diseases, but its role in such disorders is poorly understood. Herein we describe the case of a young woman who developed generalized Wegener's granulomatosis (WG) after HCMV mononucleosis and urinary tract infection. During mononucleosis, the patient had extraordinarily high plasma levels of proinflammatory cytokines such as interleukin-5 and lymphotoxin ␣, autoantibodies, and a higher blood level of viral DNA than were found in other immunocompetent patients infected with HCMV or healthy controls. Active HCMV replication was detected after the onset of vasculitis, and HCMV genomes or antigens were found in blood, urine, and inflammatory lesions on the kidney. Thus, HCMV may have triggered or exacerbated inflammation and autoimmunity in this case of WG.

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“…Recently, cytomegalovirus (CMV) has been linked to the development of inflammatory diseases and cancer (Söderberg-Naucler, 2006).…”

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confidence: 99%

Breast cancer, cytomegalovirus and Epstein–Barr virus: a nested case–control study

et al. 2010

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BACKGROUND: We investigated whether elevation in serum cytomegalovirus (CMV) or Epstein -Barr virus (EBV) immunoglobulin G (IgG) antibody levels precedes the development of breast cancer. METHODS: A nested case -control study was carried out within the Janus Serum Bank cohort. Two serum samples, one taken at least 4 years before diagnosis (sample 2) and an earlier sample (sample 1) from 399 women with invasive breast cancer and from 399 controls, matched for date of blood samples and age were tested for CMV and EBV IgG antibodies. Odds ratios (ORs) with 95% confidence intervals (CIs) for CMV and EBV seroconversion between the samples and unit changes in IgG optical density (OD) examined as a continuous variable were calculated using conditional logistic regression. RESULTS: Eleven cases and three controls seroconverted for CMV IgG between the first and second blood samples, with an adjusted OR for CMV IgG seroconversion of 4.0 (95% CI ¼ 1.1 -14.4). The risk of breast cancer, adjusted for parity, increased per unit difference in CMV OD between samples (OR ¼ 1.7, 95% CI ¼ 1.1 -2.5). In an analysis restricted to parous cases and age-matched parous controls, the OR for CMV seroconversion for IgG between the two samples, adjusted for parity and age at first birth, was 9.7 (95% CI ¼ 1.2 -77.3). The EBV seroconversion or change in EBV OD was not associated with risk of breast cancer. CONCLUSION: Our hypothesis that elevation in serum CMV IgG antibody levels precedes the development of breast cancer in some women is supported by the results of this study. Changes in EBV IgG antibody are not associated with risk of breast cancer.

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Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer?

Abstract: Abstract. Söderberg-Nauclér C (Karolinska University Hospital, Stockholm, Sweden). Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer? (Review).

Cited by 295 publications

References 273 publications

Socioeconomic disparities in the seroprevalence of cytomegalovirus infection in the US population: NHANES III

Socioeconomic disparities in the seroprevalence of cytomegalovirus infection in the US population: NHANES III

Generalized Wegener's granulomatosis in an immunocompetent adult after cytomegalovirus mononucleosis and bacterial urinary tract infection

Breast cancer, cytomegalovirus and Epstein–Barr virus: a nested case–control study

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