Does depression in multiple sclerosis mediate effects of cognitive functioning on quality of life?

Crouch, Tara A.; Reas, Hannah E.; Quach, Christina M.; Erickson, Thane M.

doi:10.1007/s11136-021-02927-w

Cited by 8 publications

(2 citation statements)

References 40 publications

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“…The negative impact of depression on cognitive function also represents an argument to explain why the results of the PASAT test at T1 are lower than those recorded at T0 [55]. Favorable results of the PASAT test are noted only in subjects who are in an incipient form of the pathology, who have the pathology for less than 1 year, and these results correlated with other studies [56,57].…”

Section: Discussionsupporting

confidence: 70%

The Early Initiation Advantages of Physical Therapy in Multiple Sclerosis—A Pilot Study

Marcu

Brihan

Ciubara

et al. 2023

Life

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(1) Background: Multiple sclerosis (MS), a chronic progressive neurological disorder which affects the central nervous system (CNS), can result in disorders of all the functions controlled by the CNS: motor, sensory, cognitive and emotional. Physical therapy (PT), conducted through proprioceptive neuromuscular facilitation (PNF) techniques, can be customized to the individual patient’s needs and has the potential to improve the patient’s evolution. This study aims to establish if PT based on PNF techniques has a beneficial role in MS treatment. (2) Methods: We performed a prospective study on 40 patients who were diagnosed with MS and previously treated only with MS drug treatment (DT). These patients have participated in a PT program throughout one year. At the beginning and at the end of our study, after one year, we have assessed the following parameters: timed walk for 25 feet (Timed 25-Foot Walk test- T25FW test), dexterity of the upper limbs (9-Hole Peg Test—9HPT), disability level (Expanded Disability Status Scale—EDSS) and cognitive function (Paced Auditory Serial Addition Test—PASAT. (3) Results: In subjects in the early stages of MS, lower limb mobility improved significantly, T25FW decreasing from 6.46 to 5.80 (p < 0.001) and upper limb ability increased significantly in the dominant hand, 9HPT decreasing from 17.73 to 16.97 (p = 0.006) and not significantly in the non-dominant hand, 9HPT decreasing from 17.73 to 17.50 (p = 0.255). Furthermore, among these subjects, cognitive performance improved; their PASAT increased from 52.14 to 54.14 (p = 0.036), while the level of disability of these subjects improved only slightly, the EDSS scale evolving from 3.08 to 2.91 (p = 0.650). (4) Conclusions: In patients with early forms of MS, combining DT with a PT program based on PNF techniques results in: regaining muscle strength in the lower limbs, improving coordination while walking, correcting dexterity in the upper limbs and increasing the ability to concentrate.

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Section: Discussionsupporting

confidence: 70%

The Early Initiation Advantages of Physical Therapy in Multiple Sclerosis—A Pilot Study

Marcu

Brihan

Ciubara

et al. 2023

Life

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“…For instance, not only have subjective estimates of cognitive function been shown to be weakly correlated with objective indicators of cognitive abilities in MS, 7 objective and subjective estimates of cognitive functioning function have also been identified as independent predictors of broader MS‐related quality of life. 8 Also of interest in this study was therefore whether OHRQoL in this clinical group is related to oral health, as indexed by an objective oral health assessment.…”

Section: Introductionmentioning

confidence: 99%

Oral health‐related quality of life is more strongly correlated with mental health than with oral health in relapsing–remitting multiple sclerosis

Henry

Manchery

Swayne

et al. 2022

J of Oral Rehabilitation

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Background: Multiple sclerosis (MS) is a leading cause of neurological disability in young and middle-aged populations, associated with substantial burden of illness.Because a growing literature now shows that this burden extends to poorer oral health, oral health-related quality of life (OHRQoL) may be reduced as well.Objectives: To test whether people with relapsing-remitting MS (RRMS) have poorer OHRQoL than demographically matched controls, and to establish which variables are associated with worse OHRQoL. Materials and Methods:In total, 64 people with RRMS and 69 demographically matched controls participated. Both groups completed the Oral Health Impact Profile (OHIP-14), a validated measure of OHRQoL, as well as an objective oral health examination performed by a qualified dentist, a measure of dental-related functionality and a measure of mental health.Results: OHRQoL was significantly poorer in the RRMS relative to the control group.However, although poorer OHRQoL in the RRMS group was moderately associated with objectively assessed oral health (r = .30), it was more strongly associated with mental health (r = .61). For the control group, the reverse pattern of association was evident, with OHRQoL more strongly associated with oral health (r = .48) relative to mental health (r = .20). Conclusion:People with RRMS report poorer OHRQoL than demographically matched controls, but these appraisals are more strongly linked to mental health than to objective oral health indicators. K E Y W O R D S multiple sclerosis, neurological disorder, oral health, oral health-related quality of life, wellbeing | 63 NANGLE et al. How to cite this article: Nangle MR, Manchery N, Swayne A, Boocock H, Blum S, Henry JD. Oral health-related quality of life is more strongly correlated with mental health than with oral health in relapsing-remitting multiple sclerosis.

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Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms

Jellinger

2024

J Neural Transm

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Does depression in multiple sclerosis mediate effects of cognitive functioning on quality of life?

Cited by 8 publications

References 40 publications

The Early Initiation Advantages of Physical Therapy in Multiple Sclerosis—A Pilot Study

The Early Initiation Advantages of Physical Therapy in Multiple Sclerosis—A Pilot Study

Oral health‐related quality of life is more strongly correlated with mental health than with oral health in relapsing–remitting multiple sclerosis

Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms

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