Does Diabetes Mellitus Explain the Higher Hospital Mortality of Women with Acute Myocardial Infarction? Results from the Berlin Myocardial Infarction Registry

Maier, Berenike; Thimme, W; Kallischnigg, Gerd; Graf-Bothe, Claudia; Röhnisch, Jens-Uwe; Hegenbarth, Claire; Theres, Heinz

doi:10.2310/6650.2006.05056

Cited by 15 publications

(14 citation statements)

References 38 publications

(55 reference statements)

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“…In our study, diabetic women had significantly higher mortality rates than diabetic men. These results are consistent with those of other studies that specifically analyze the interaction between gender and diabetes [9,18,19]. In the Secondary Prevention Reinfarction Israeli Nifedipine Trial (SPRINT) study, diabetes was a significant predictor of hospital mortality after AMI in women, but not in men.…”

Section: Discussionsupporting

confidence: 90%

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Trends of hospitalizations, fatality rate and costs for acute myocardial infarction among Spanish diabetic adults, 2001-2006

López‐de‐Andrés

Hernández-Barrera

Carrasco‐Garrido

et al. 2010

BMC Health Serv Res

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Background: Acute myocardial infarction (AMI) is one of the more frequent reasons diabetic patients are admitted to hospital, and there are reports that the long-term prognosis after an AMI is much worse in these patients than in non-diabetic patients. This study aims to compare hospital admissions and costs in Spanish diabetic and nondiabetic subjects due to AMI during the period 2001-2006. Methods: We conducted a retrospective study of 6 years of national hospitalization data associated with diabetes using the Minimum Basic Data Set. National hospitalization rates were calculated for AMI among diabetic and nondiabetic adults. Fatality rates, mean hospital stay and direct medical costs related to hospitalization were analyzed. Costs were calculated using Diagnosis-Related Groups for AMI in diabetics and non-diabetics patients.

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Section: Discussionsupporting

confidence: 90%

“…The literature clearly shows that women have a lower incidence of AMI than men [17,18]. However, hospitalized women have been reported to undergo fewer diagnostic or revascularization procedures, and therefore have a higher mortality rate [19].…”

Section: Discussionmentioning

confidence: 99%

Trends of hospitalizations, fatality rate and costs for acute myocardial infarction among Spanish diabetic adults, 2001-2006

López‐de‐Andrés

Hernández-Barrera

Carrasco‐Garrido

et al. 2010

BMC Health Serv Res

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“…Earlier research also showed that the case fatality rates for ACS events in diabetic individuals is elevated and that the prognosis is worse than in non-diabetic persons [7][8][9][10]. Some studies have suggested that the prognosis for diabetic women after an acute myocardial infarction is worse than that for diabetic men [11].…”

Section: Introductionmentioning

confidence: 99%

Case fatality rates after first acute coronary syndrome in persons treated for type 2 diabetes show an improving trend

et al. 2009

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Aims/hypothesis We analysed whether the prognosis of a first acute coronary syndrome (ACS) in patients treated for type 2 diabetes has improved. We also compared the trends in patients with and without diabetes. Methods We used national registers to identify all patients with clinically known type 2 diabetes in Finland during the years 1988 to 2002 (n=222,940). All first-ever ACS events (n=43,412) among these patients were identified using the Hospital Discharge Register and the Causes of Death Register. From the National Cardiovascular Disease Register we identified all first ACS attacks (n=191,403) among non-diabetic patients in the country. Finally, we calculated annual age-standardised case fatality rates for ACS for three time periods: prehospital, days 0 to 27 and days 28 to 364 after the first ACS. Results The case fatality rate of first ACS declined significantly in both sexes at all time points considered. The declining trends were not different between patients with type 2 diabetes and those without. Among men aged 35 to 74 years, 58.5% (95% CI 57.6-59.4%) with type 2 diabetes and 44.1% (95% CI 43.8-44.5%) without diabetes had died from cardiovascular causes 1 year after their first ACS. Among women of the same age, the corresponding figures were 54.2% (95% CI 53.0-55.4%) and 36.5% (95% CI 35.9-37.1%). Men generally had higher case fatality rates than women. However, except for prehospital deaths, diabetic women had the same or even higher case fatality rates than non-diabetic men. Conclusions/interpretation The case fatality rates for first ACS show similar improving trends in patients with type 2 diabetes and in those without. However, case fatality rates have remained higher in patients with type 2 diabetes.

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“…В конце 20-го века частота развития ИБС у мужчин, страдающих СД2, в 2 раза, а у женщин с СД2 в 3 раза превышали частоту встречаемости ИБС в общей популяции [5]. В 21-м веке это соотношение не измени-лось [6]. По данным регистра больных ОИМ в Берлине в возрасте от 30 до 55 лет, от ИБС умирают 35% больных СД2, в то время как в общей популяции ИБС является причиной смерти только у 8% мужчин и 4% женщин этой же возрастной категории [6].…”

Section: /2013unclassified

“…В 21-м веке это соотношение не измени-лось [6]. По данным регистра больных ОИМ в Берлине в возрасте от 30 до 55 лет, от ИБС умирают 35% больных СД2, в то время как в общей популяции ИБС является причиной смерти только у 8% мужчин и 4% женщин этой же возрастной категории [6]. В эпоху тромболи-тической терапии и применения инвазивных методов лечения в раннем периоде ОИМ летальность при нали-чии СД2 по-прежнему остается в 2-3 раза выше в срав-нении с пациентами без нарушения углеводного обмена (УО) [1,7,8].…”

Section: /2013unclassified

Clinical and morphological characteristics, management and prognosis for acute coronary syndrome in patients with type 2 diabetes mellitus

et al. 2013

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This review addresses clinical picture of acute coronary syndrome (ACS) in patients with type 2 diabetes mellitus (T2DM), the corre- sponding epidemiology data, morphological characteristics and prognosis. ACS in patients with T2DM features fulminant development, and its high lethality is due to chronic ischemic alterations in myocardium (the so-called ?metabolic ischemia?), as well as concomitant microangiopathy. It is more common for patients with T2DM to develop such complications of ACS as cardiogenic shock, acute left ventricular failure and arrhythmia that result in increased lethality during early hours of hospital admission when myocardial necrosis is yet to occur. Percutaneous translumenal intervention is by far the most effective method of ACS management in patients with T2DM. Whenever it is not available, a thrombolytic approach is indicated.

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Does Diabetes Mellitus Explain the Higher Hospital Mortality of Women with Acute Myocardial Infarction? Results from the Berlin Myocardial Infarction Registry

Cited by 15 publications

References 38 publications

Trends of hospitalizations, fatality rate and costs for acute myocardial infarction among Spanish diabetic adults, 2001-2006

Trends of hospitalizations, fatality rate and costs for acute myocardial infarction among Spanish diabetic adults, 2001-2006

Case fatality rates after first acute coronary syndrome in persons treated for type 2 diabetes show an improving trend

Clinical and morphological characteristics, management and prognosis for acute coronary syndrome in patients with type 2 diabetes mellitus

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