Does Diabetes Mellitus Increase the Short- and Long-Term Mortality in Patients With Critical Acute Myocardial Infarction? Results From American MIMIC-III and Chinese CIN Cohorts

Chen, Shiqun; Huang, Zhidong; Chen, Liling; Zhao, Xiaoli; Kang, Yu Mi; Lai, Wenguang; Lü, Xin; Zhou, Yang; He, Yibo; Huang, Haozhang; Li, Qiang; Jin, Liu; Dong, Shaohong; Tan, Ning; Liu, Yong; Chen, Jiyan

doi:10.3389/fendo.2021.797049

Cited by 7 publications

(5 citation statements)

References 32 publications

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“…First, we are limited to variables measured and end points published in each study, as with many meta-analyses. Also, many recently published studies related to the topic did not provide sex-specific post-AMI all-cause mortality in both patients with and without diabetes, thus they can’t be included in the review ( 54 – 56 ). Although we followed the PRISMA guidelines and used an extensive search strategy to identify existing literature in multiple databases, the majority of the included studies were observational cohort studies with greater potential for bias and between-study heterogeneity than randomized controlled trials ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

Sex-specific impact of diabetes on all-cause mortality among adults with acute myocardial infarction: An updated systematic review and meta-analysis, 1988-2021

et al. 2022

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BackgroundThe prevalence of diabetes and its impact on mortality after acute myocardial infarction (AMI) are well-established. Sex-specific analyses of the impact of diabetes on all-cause mortality after AMI have not been updated and comprehensively investigated.ObjectiveTo conduct a systematic review and meta-analysis that examined sex-specific short-term, mid-term and long-term all-cause mortality associated with diabetes among AMI survivors (diabetes versus non-diabetes patients in men and women separately), using up-to-date data.MethodsWe systematically searched Embase and MEDLINE for studies that were published from inception to November 14, 2021. Studies were included if (1) they studied post-AMI all-cause-mortality in patients with and without diabetes, (2) sex-specific all-cause mortality at short-term (in-hospital or within 90 days after discharge), mid-term (>90 days and within 5 years), and/or long-term (>5 years) were reported. From eligible studies, we used random effects meta-analyses models to estimate pooled unadjusted and adjusted sex-specific risk ratio (RR) of all-cause mortality at short-, mid-, and long-term follow-up for adults with diabetes compared with those without diabetes.ResultsOf the 3647 unique studies identified, 20 studies met inclusion criteria. In the unadjusted analysis (Total N=673,985; women=34.2%; diabetes patients=19.6%), patients with diabetes were at a higher risk for all-cause mortality at short-term (men: RR, 2.06; women: RR, 1.83); and mid-term follow-up (men: RR, 1.69; women: RR, 1.52) compared with those without diabetes in both men and women. However, when adjusted RRs were used (Total N=7,144,921; women=40.0%; diabetes patients=28.4%), the associations between diabetes and all-cause mortality in both men and women were attenuated, but still significantly elevated for short-term (men: RR, 1.16; 95% CI, 1.12-1.20; women: RR, 1.29; 95% CI, 1.15-1.46), mid-term (men: RR, 1.39; 95% CI, 1.31-1.46; women: RR, 1.38; 95% CI, 1.20-1.58), and long-term mortality (men: RR, 1.58; 95% CI, 1.22-2.05; women: RR, 1.76; 95% CI, 1.25-2.47). In men, all-cause mortality risk associated with diabetes tended to increase with the duration of follow-up (p<0.0001).ConclusionsDiabetes has substantial and sustained effects on post-AMI all-cause mortality at short-term, mid-term and long-term follow-up, regardless of sex. Tailoring AMI treatment based on patients’ diabetes status, duration of follow-up and sex may help narrow the gap in all-cause mortality between patients with diabetes and those without diabetes.

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Section: Discussionmentioning

confidence: 99%

Sex-specific impact of diabetes on all-cause mortality among adults with acute myocardial infarction: An updated systematic review and meta-analysis, 1988-2021

et al. 2022

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“…Prevalence of DM in AMI patients varied from 20-30% (Arnold, 2014), but it keeps increasing (Gandhi, 2006). Based on a study in 2021 between two cohorts from American and Chinese, the result showed DM is often find in critical AMI patients (almost half and one-third) (Chen, 2021). According to a study in Qatar, as much as 54% prevalence of DM was shown in critical AMI patients (El-Menyar, 2009).…”

Section: Type 2 Diabetes Mellitus and Acute Myocardiac Infarctionmentioning

confidence: 99%

“…DM used as a good predictor for prognostic in AMI patients. In patients with AMI, DM contribute to 2 until 9 times higher risk of death (Chen, 2021). During a study in Italy, the death of DM patients with STEMI was also trigger by the predominant factors of the patients who have cardiorenal dysfunction (Marenzi, 2019).…”

Section: Type 2 Diabetes Mellitus and Acute Myocardiac Infarctionmentioning

confidence: 99%

Acute Myocardiac Infarctions and Type 2 Diabetes Mellitus (T2DM) : a Literature Review

Khairul¹,

Pranoto²,

Yusuf³

2023

IJRP

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Diabetes mellitus (DM) is known to be a metabolic disorder happened to be chronic and identified with persistent hyperglycemia. It might be due to insulin secretion, insulin resistance or both disorders. Coronary artery disease is known to be the top killer in the world. According to WHO, as much as 17.5 million people died of cardiovascular disease. Diabetes mellitus and its correlation with coronary artery disease have been acknowledge since ages ago and known to be separate entities. As one of the risk factors, the hyperglycemia caused by DM might affect patients by enhancing the process of early atherosclerosis that attach the vital organs. This study aims to review past literature and studies regarding type 2 diabetes mellitus and acute myocardial infarction

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“…All analysis processes were finished with R software (version 4.2.2). In cleaning clinical data, the R packages nhanesR (version 0.9.4.1) were served for NHANES, and pgAdmin PostgreSQL (version 14.1) [20][21][22] was applied in MIMIC.…”

Section: Statistical Analysesmentioning

confidence: 99%

Red blood cell distribution width/albumin ratio is a novel risk factor of incidence and long-term mortality in chronic heart failure patients: three large cohorts from China and America

Zhang,

Zhou,

Wang

et al. 2023

Preprint

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Aims: Red blood cell distribution width/albumin ratio (RAR) is a novel parameter associated with inflammation. Previous studies have not focused on the role of RAR in the incidence and long term prognosis of chronic heart failure (CHF). This study included three cohorts, two prospective and one retrospective study. The aim was to investigate the value of RAR in the incidence of CHF and the long term prognosis of CHF. Methods: Three cohorts were investigated, including MIMIC, NHANES, and JHDH. The included patients of MIMIC, NHANES, and JHDH were 22,672 from 2001 to 2012, 60,754 from 1999 to 2020, and 15,102 from 2021 to 2022, respectively. According to whether the patients have CHF related risk factors, the patients were classified into non CHF, pre CHF, and CHF groups. The median follow up time of MIMIC and NHANES was 364 days and 62 months. Logistic regression, Cox regression, restricted cubic spline (RCS), and Kaplan Meier (KM) curves were used to analyze the value of RAR in CHF patients. Result: In NHANES, the CHF prevalence in quartiles of RAR (Q1, Q2, Q3, and Q4) were 8.88%, 16.86%, 27.65%, and 46.61%, respectively. MIMIC and JHDH showed a similar trend. Among the non CHF and CHF patients, the odds ratio (OR) was 1.45 (JHDH 95% CI 1.33,1.58) and 1.93 (NHANES 95% CI 1.41,2.65). In NHANES, the RAR OR value of Q2, Q3 and Q4 were 2.02(CI 1.19,3.43), 3.24(CI 1.95,5.39), and 4.95(CI 2.44,10.02) compared with Q1, respectively. And the OR was 1.05 (MIMIC 95% CI 1.02,1.07) in pre-CHF and CHF patients. The CHF mortality showed an adjusted hazard ratio (HR) is 1.12 (MIMIC 95% CI 1.1,1.14) and 2.26 (NHANES 95% CI 1.52,3.36). KM demonstrates that higher RAR (>3.4 in NHANES and >5.06 in MIMIC) prognoses lead to poor survival in CHF patients. CHF mortality in the 19th quartile of the RAR was 1.4 times higher than in the first quartile, compared with 1.22 times in the red blood cell distribution width (RDW). The 19-quartile mortality curves of the RAR were more stable than RDW and albumin (ALB). Conclusion: RAR is an independent risk factor for incidence and all cause long term mortality in CHF patients. The predictive value of RAR for all cause mortality in CHF is superior to ALB and RDW. RAR may be a potential clinical indicator for future treatment of CHF.

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Does Diabetes Mellitus Increase the Short- and Long-Term Mortality in Patients With Critical Acute Myocardial Infarction? Results From American MIMIC-III and Chinese CIN Cohorts

Cited by 7 publications

References 32 publications

Sex-specific impact of diabetes on all-cause mortality among adults with acute myocardial infarction: An updated systematic review and meta-analysis, 1988-2021

Sex-specific impact of diabetes on all-cause mortality among adults with acute myocardial infarction: An updated systematic review and meta-analysis, 1988-2021

Acute Myocardiac Infarctions and Type 2 Diabetes Mellitus (T2DM) : a Literature Review

Red blood cell distribution width/albumin ratio is a novel risk factor of incidence and long-term mortality in chronic heart failure patients: three large cohorts from China and America

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