Does Dietary Elimination in Infancy Prevent or Only Postpone a Food Allergy?

Saarinen, UllaM.; Kajosaari, Merja

doi:10.1016/s0140-6736(80)90657-1

Cited by 82 publications

(26 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…É possível que o controle dos alérgenos simplesmente retarde o aparecimento de manifestaçoes alérgicas. 9 Ácaros da poeira doméstica do gênero Dermatophagoide constituem-se na mais importante fonte de alérgenos da poeira e uma causa comum de sintomas em doenças mediadas por IgE. 10 A identificação de ácaros em amostras de poeira de residências em vários países tem demonstrado a ocorrência de 3 espécies principais: Dermatophagoides pteronyssinus (Dpt), Dermatophagoides farinae (Df) e Dermatophagoides microcera (Dm).…”

Section: Etiologia Da Doença Atópica Em Crianças Brasileirasestudo Muunclassified

Atopic diseases in Brazilian children - Etiologic multicentric study

Rizzo¹,

Solé²,

Rizzo³

et al. 1995

J Pediatr (Rio J)

View full text Add to dashboard Cite

31 ResumoCom o intuito de diagnosticar os principais agentes etiológi-cos das doenças atópicas em crianças brasileiras (3 a 16 anos), realizamos o presente estudo multicêntrico em oito diferentes regiões do Brasil (n=306), testando-se por meio do prick test, uma bateria padronizada de antígenos inalantes e alimentos (IFIDESA ARISTEGUI). Foram considerados positivos os diâmetros mé-dios de pápulas 3 mm. 22,2% dos pacientes tiveram teste negativo e a maioria restante foi positiva aos inalantes: D. pteronyssinus(Dpt) (66,6%) e D. farinae (Df) (66,0%), extrato de pó domiciliar (29,0%), epitélio de cão (19,2%), epitélio de gato (8,8%), penas (5,5%), fungos (4,2%), Penicillium sp (2,2%) e Lollium perene (0,6%). Com relação aos alimentos, observamos ocorrência de 9,1% de testes positivos, sendo a distribuição em ordem decrescente: leite de vaca (5,2%), amendoim (3,5%), milho (3,2), cacau e soja (2,2%), ovos e trigo (1,9%). Esses dados demonstram que os ácaros domésticos constituem-se nos principais agentes etiológicos da doença atópica em nosso meio, sendo necessária a determinação da população acarina em cada região do país e a aplicação de testes cutâneos com extratos específicos para cada realidade.J. pediatr. (Rio J.). 1995; 71(1):31-35: alergia, atopia, testes cutâneos, alérgenos inalantes, alimentos. AbstractIn order to determine the etiologic agents involved in atopic diseases in Brazilian children, we have performed this multicentric study in 8 areas in Brazil. We have done prick tests with inhalants and food antigens and analyzed skin tests results, considering positive the wheal mean diameter 3 mm. 22,2% of skin tests were negative and the majority were positive to inhalants: D.pteronyssinus(Dpt) (66,6%) and D. farinae(Df) (66,0%), house dust extract (29,0%), dog's epithelium (19,2%), cat's epithelium (8,8%), feather (5,5%), molds (4,2%), Penicillium sp (2,2%) and Lollium perene (0,6%). We have had 9,1% of food positive tests: cow milk (5,2%), peanut (3,5%), corn (3,2%), cocoa and soya (2,2%), eggs and wheat (1,9%). We have concluded that the domestic mites are the most important agents involved in the etiology of atopic diseases in Brazilian children, and the extracts involved, in line with the sensitization of each geographical area.J. pediatr. (Rio J.). 1995; 71(1):31-35: allergy, atopy, skin tests, inhalant allergens; food.Estima-se que o risco de alergia na população geral, seja próximo de 20%, aumentando para 50% se um dos pais for alérgico, ou para 66% se ambos o forem. 3,4,5 A importância relativa de um alérgeno individual é usualmente definida pela porcentagem de pacientes alérgi-cos que apresentem níveis séricos de IgEs específicas a esta proteína: quando mais de 60% dos pacientes apresentam IgE específica para determinado alérgeno, ele é considerado um alérgeno principal. 6 Cada indivíduo atópico apresenta um "marcador" alérgi-co, manifestado por hiperreatividade somente a certos antí-genos e determinado primariamente por fatores genéticos e exposição ambiental. 7,8 A resposta não se limita à sí...

show abstract

Section: Etiologia Da Doença Atópica Em Crianças Brasileirasestudo Muunclassified

Atopic diseases in Brazilian children - Etiologic multicentric study

Rizzo¹,

Solé²,

Rizzo³

et al. 1995

J Pediatr (Rio J)

View full text Add to dashboard Cite

show abstract

“…For example, citrus fruits have been described belonging to the ten major offenders among allergenic foods [1]. Studies performed in Finland revealed citrus fruits as common cause of allergy, especially in children, with a frequency of about 3% at the age of 3 years [2,3]. Approximately 10% of atopic asthmatic children with food allergy reported symptoms after ingestion of orange [4].…”

Section: Introductionmentioning

confidence: 99%

Germin‐like protein Cit s 1 and profilin Cit s 2 are major allergens in orange (Citrus sinensis) fruits

Crespo

Retzek

Foetisch

et al. 2006

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Oranges are clinically relevant allergenic foods. To date, orange allergens have not been characterized in detail. The study is aimed at analyzing the sensitization profile in orange-sensitized subjects with and without clinical allergy, and to identify orange allergens. Fifty-six sensitized subjects with selfreported reactions to orange were grouped into reactors (anaphylaxis or multiple episodes of immediate reactions and/or positive challenge tests) and non-reactors (negative open food challenge tests). Allergens were characterized by IgE immunoblotting, N-terminal sequencing, IgE-inhibition assays, and mediator release assays were performed to determine the allergenic potency of orange profilin. Of 56 subjects, 23 were classified as orange allergic showing mainly an oral allergy syndrome. Of 23 subjects classified as orange allergic, 22 were sensitized to profilin, Cit s 2. In patients with monosensitization to profilin in vitro histamine releases up to 75% from basophils were induced using orange extract and purified plant profilins. Of the allergic patients 78% were sensitized to germinlike protein, Cit s 1. Both allergens showed retained IgE reactivity in heat-processed orange juice. Interestingly, subjects with and without clinical allergy showed a comparable sensitization profile. Profilin and germin-like proteins are major orange allergens. The potential clinical relevance of orange profilin was indicated by its strong capacity to release histamine from basophils. However, a predominant sensitization to both allergens in subjects without symptoms also indicates a high frequency of clinically insignificant sensitization.

show abstract

“…juice and jam) in the European and American diet. However, studies on orange allergy are very limited [1,2,3,4,5,6,7], and most of them have dealt with non-orange allergens (enzymes used in fruit processing [4] or from citrus mites [5]), minor non-protein components of citrus peel oil [3] or non-IgE-mediated reactions [6]. Accordingly, no orange fruit allergen has been isolated and characterized to date.…”

Section: Introductionmentioning

confidence: 99%

Lipid Transfer Proteins and Allergy to Oranges

Ahrazem¹,

Ibáñez

López‐Torrejón³

et al. 2005

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Lipid transfer proteins (LTPs) are relevant fruit allergens, recently proposed as model plant food allergens. No citrus fruit allergen has been characterized to date. We sought to identify and isolate citrus fruit LTPs and to explore their relevance in orange allergy. Methods: Twenty-seven patients, showing mainly oral allergy syndrome after orange ingestion, as well as positive prick responses and serum-specific IgE levels to orange, were selected. Natural orange and lemon LTPs, as well as a recombinant orange LTP isoform expressed in Pichia pastoris, were isolated by chromatographic methods and characterized by N-terminal amino acid sequencing and matrix-assisted laser desorption/ionizaion mass spectrometry, and DNA sequencing of the corresponding cDNA in the case of the recombinant allergen. Specific IgE determination, immunodetection, ELISA-inhibition assays and in vivo skin prick tests (SPTs) were performed with all three purified allergens and with the major peach LTP allergen, Pru p 3. Results: The natural allergens purified from orange (nCit s 3) and lemon (nCit l 3) showed very similar N-terminal amino acid sequences (18 out of 20 identical residues), typical of LTPs, and molecular masses of 9,610 and 9,618 Da, respectively. The recombinant orange isoform (rCit s 3) expressed in P. pastoris (16 out of 20 residues identical to its natural counterpart in the N-terminal region) presented 92 amino acid residues and 9,463 Da, and 67% sequence identity with rPru p 3. Of the 27 sera analyzed, specific IgE to the purified allergens was found in 54% for nCit l 3, 48% for nCit s 3, 46% for rCit s 3 and 37% for rPru p 3. Positive SPT responses were obtained in 7 out of 26 patients tested for nCit s 3, 3 out of 8 for nCit l 3 and 10 out of 26 for nPru p 3. ELISA-inhibition assays showed an equivalent IgE-binding pattern for the natural and recombinant orange LTPs, and IgE cross-reactivity among the purified orange, lemon and peach LTP allergens. Conclusions: Members of the LTP allergen family are involved in allergy to oranges, displaying positive in vitro and in vivo reactions in 30–50% of the patients studied. Both orange and lemon allergens show cross-reactivity with the major peach allergen Pru p 3.

show abstract

Does Dietary Elimination in Infancy Prevent or Only Postpone a Food Allergy?

Cited by 82 publications

References 7 publications

Atopic diseases in Brazilian children - Etiologic multicentric study

Atopic diseases in Brazilian children - Etiologic multicentric study

Germin‐like protein Cit s 1 and profilin Cit s 2 are major allergens in orange (Citrus sinensis) fruits

Lipid Transfer Proteins and Allergy to Oranges

Contact Info

Product

Resources

About