Does diffusion‐weighted imaging improve therapy response evaluation in patients with hepatocellular carcinoma after radioembolization? comparison of MRI using Gd‐EOB‐DTPA with and without DWI

Schelhorn, Juliane; Best, Jan; Reinboldt, M; Dechêne, Alexander; Gerken, Guido; Ruhlmann, Marcus; Lauenstein, Thomas C.; Antoch, Gerald; Kinner, Sonja

doi:10.1002/jmri.24827

Cited by 14 publications

(8 citation statements)

References 42 publications

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“…DWI is an increasingly used MR technique, which enables the visualization of diffusivity of water molecules, and may provide information regarding the cellular density and properties of the extracellular matrix [21]. All lesions were hyperintense on DWI, and the marked restricted diffusion can raise suspicion for cHCC-CC, which was supported by Potretzke et al [10].…”

Section: Discussionmentioning

confidence: 94%

MR comparative study of combined hepatocellular-cholangiocarcinoma in normal, fibrotic, and cirrhotic livers

Sheng

Xie

et al. 2016

Abdom Radiol

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Section: Discussionmentioning

confidence: 94%

MR comparative study of combined hepatocellular-cholangiocarcinoma in normal, fibrotic, and cirrhotic livers

Sheng

Xie

et al. 2016

Abdom Radiol

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“…No statistically significant difference between Gd-MRI, DWI, and the combination of both in terms of diagnostic accuracy was evident. In some cases, however, DWI provided additional information to detect HCC progression, which was missed by Gd-MRI alone [ 37 ].…”

Section: The Value Of Diffusion-weighted Imaging For Locoregional mentioning

confidence: 99%

The Role of Diffusion-Weighted Imaging (DWI) in Locoregional Therapy Outcome Prediction and Response Assessment for Hepatocellular Carcinoma (HCC): The New Era of Functional Imaging Biomarkers

et al. 2015

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Reliable response criteria are critical for the evaluation of therapeutic response in hepatocellular carcinoma (HCC). Current response assessment is mainly based on: (1) changes in size, which is at times unreliable and lag behind the result of therapy; and (2) contrast enhancement, which can be difficult to quantify in the presence of benign post-procedural changes and in tumors presenting with a heterogeneous pattern of enhancement. Given these challenges, functional magnetic resonance imaging (MRI) techniques, such as diffusion-weighted imaging (DWI) have been recently investigated, aiding specificity to locoregional therapy response assessment and outcome prediction. Briefly, DWI quantifies diffusion of water occurring naturally at a cellular level (Brownian movement), which is restricted in multiple neoplasms because of high cellularity. Disruption of cellular integrity secondary to therapy results in increased water diffusion across the injured membranes. This review will provide an overview of the current literature on DWI therapy response assessment and outcome prediction in HCC following treatment with locoregional therapies.

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“…In imaging after radioembolization, some studies of HCC have suggested that the addition of DWI MRI can contribute to the understanding of tumor response to treatment; however, others have found that addition of DWI offers no significant improvement in this evaluation [85,86]. Liver metastases treated with Y-90 therapy have shown decreased metabolic activity on PET scan following treatment, suggesting that PET could potentially be used as a tool in determining tumor response to radioembolization therapy [87][88][89].…”

Section: Transarterial Chemoembolization and Radioembolizationmentioning

confidence: 94%

Current Status of Imaging to Evaluate Liver Metastases From Colorectal Cancer

Postlewait

Maithel

2015

Curr Colorectal Cancer Rep

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Multiple imaging modalities are routinely used to identify, characterize, and clinically follow colorectal cancer liver metastases. These include ultrasound, computed tomography, magnetic resonance imaging, and positron emission tomography. Within each modality, there exist multiple variations of protocol, which could include addition of contrast, acquisition of specific imaging sequences, or combination of images with those of another modality. In addition to considerations of imaging protocols and equipment, one must also consider patient-specific factors to determine appropriate imaging for colorectal cancer liver metastases. Specifically, whether the patient has been treated systemically or locally is important in determining imaging strategy. This review highlights the benefits, limitations, and variations of each modality and offers comparative data among the imaging techniques.

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Does diffusion‐weighted imaging improve therapy response evaluation in patients with hepatocellular carcinoma after radioembolization? comparison of MRI using Gd‐EOB‐DTPA with and without DWI

Abstract: Additional DWI does not substantially improve therapy response evaluation by Gd-EOB MRI in HCC after radioembolization but proved helpful in single cases.

Cited by 14 publications

References 42 publications

MR comparative study of combined hepatocellular-cholangiocarcinoma in normal, fibrotic, and cirrhotic livers

MR comparative study of combined hepatocellular-cholangiocarcinoma in normal, fibrotic, and cirrhotic livers

The Role of Diffusion-Weighted Imaging (DWI) in Locoregional Therapy Outcome Prediction and Response Assessment for Hepatocellular Carcinoma (HCC): The New Era of Functional Imaging Biomarkers

Current Status of Imaging to Evaluate Liver Metastases From Colorectal Cancer

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