Does Dimenhydrinate Control Vomiting in Children after Outpatient Strabismus Surgery?

Vener, David F.; As, Carr; Sikich, Nancy; Bissonette, Bruno; Lerman, J.

doi:10.1097/00000542-199409001-00021

Cited by 7 publications

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“…These nmnbers were too small for any significant conclusions to be drawn regarding differences in rates of postoperative drowsiness. Other studies have concluded that the use of dimenhydrinate is not associated with excessive drowsiness [17].…”

Section: Discussionmentioning

confidence: 97%

Antiemetic efficacy of prophylactic dimenhydrinate (Dramamine) vs ondansetron (Zofran)

et al. 2000

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Prophylactic administration of dimenhydrinate is as effective as the use of ondansetron in preventing PONV in patients undergoing elective laparoscopic cholecystectomy. Dimenhydrinate is the preferred drug because it is less expensive. With more than 500, 000 laparoscopic cholecystectomies performed in the United States each year, the potential drug cost savings from the prophylactic administration of dimenhydrinate instead of ondansetron exceed $7.25 million per year.

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Section: Discussionmentioning

confidence: 97%

Antiemetic efficacy of prophylactic dimenhydrinate (Dramamine) vs ondansetron (Zofran)

et al. 2000

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Are antiemetics cost-effective for children?

Lerman

1995

Can J Anaesth

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Vomiting after strabismus surgery in children: ondansetronvs propofol

1997

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Vomiting after strabismus surgery in children: ondansetron vs propofolPurpose: To compare the antiemetic efficacy and costs associated with two anaesthetic regimens in children undergoing strabismus surgery, One regimen contained halothane, nitrous oxide and ondansetron, while the other contained propofol and nitrous oxide. Methods: Three hundred children aged 2-14 yr undergoing strabismus surgery were enrolled into this single-blind, randomized, stratified, blocked study with a balanced design. Anaesthesia was induced by inhalation with halothane/N20/O 2 (Group O) or with 2,5-3.5 mg.kg -~ propofol + 0.5 mg'kg -~ lidocaine/v (Group P). Group O patients were administered 0.15 mg'kg -I ondansetron (maximum dose 8 rag)/v and all patients received atropine 20/~g'kg -I /v immediately after induction of anaesthesia. Anaesthesia was maintained with N20 and halothane (Group O) or N~O and propofol (Group P). Patients were followed for 24 hr after their operaSon primarily to assess the incidence of postoperative vomiting. For each case, the costs of the anaesthetic drugs administered and their associated intravenous administration tubing were determined. Drug costs were those prevailing at the study site at the time of the investigation. Fixed costs, such as the cost of the anaesthetic equipment were not assessed. Results: Groups were similar with respect to demographic data. The incidence of vomiting in both groups was I I% while in-hospital and 2396 after discharge. Each episode of in-hospital vom~ng prolonged discharge by 17+-.4 rain, P < 0,001. Mean cost per case for anaesthetic drugs was less in Group 0, 18 _+ 8 vs 21 +_ 10 CDN$, mean _+ SD, P < 0,01. Conclusion: The two methods of antiemetic prophylaxis were equally effective. Propofol-based anaesthesia was more expensive.

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Does Dimenhydrinate Control Vomiting in Children after Outpatient Strabismus Surgery?

Cited by 7 publications

References 0 publications

Antiemetic efficacy of prophylactic dimenhydrinate (Dramamine) vs ondansetron (Zofran)

Antiemetic efficacy of prophylactic dimenhydrinate (Dramamine) vs ondansetron (Zofran)

Are antiemetics cost-effective for children?

Vomiting after strabismus surgery in children: ondansetronvs propofol

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