The transition to sustainable development and the new industrial transformation of resource-dependent countries are closely intertwined. The cluster approach is an effective means of realizing industrial potential in the context of innovative development. Clusters’ innovation potential is influenced by the network synergies that result from active regional policies. The article considers the mechanism of supporting regional clusters by creating and maintaining the viability of regional innovative systems that enhance the effect of the creation of agglomerations, and allow industrial clusters to move to innovative clusters. The latter are the highest form of enterprise development, as the connection with territorial advantages is lost. In addition, the article raises the question of the feasibility of diversifying regional economies by creating tourist clusters and promoting their brands. This type allows economies to be more resilient to crises, to increase attention to environmental issues, and to further increase the revenue part of budgets.