Does DNA methylation regulate metamorphosis? The case of the sea lamprey (Petromyzon marinus) as an example

Covelo-Soto, Lara; Saura, María; Morán, Paloma

doi:10.1016/j.cbpb.2015.03.007

Cited by 27 publications

(14 citation statements)

References 42 publications

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“…In particular, the number of polymorphic methylation-sensitive loci (MSL) available for analysis was in the uppermost range of the number of analyzed MSL in similar ecologically-oriented studies using the same technique 59 , 64 , 65 . Lastly, the results on hemi-methylated DNA observed in this study are comparable to what has been observed using MSAP in other fish species 47 , 66 , as well as in other vertebrates 59 , 67 .…”

Section: Discussionsupporting

confidence: 89%

“…Significant single loci were identified after adjusting by the method of Benjamini and Hochberg (FDR < 0.05) the p -values obtained from multiple Fisher’s exact tests for count data on the polymorphic MSL 47 . In the case of temperature acclimation (experiment 1.2), the common significant loci between the two types of temperature changes (15 °C to 19 °C and 19 °C to 15 °C) were identified.…”

Section: Methodsmentioning

confidence: 99%

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Small ocean temperature increases elicit stage-dependent changes in DNA methylation and gene expression in a fish, the European sea bass

Anastasiadi

Díaz

Piferrer

2017

Sci Rep

106

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In natural fish populations, temperature increases can result in shifts in important phenotypic traits. DNA methylation is an epigenetic mechanism mediating phenotypic changes. However, whether temperature increases of the magnitude predicted by the latest global warming models can affect DNA methylation is unknown. Here, we exposed European sea bass to moderate temperature increases in different periods within the first two months of age. We show that increases of even 2 °C in larvae significantly changed global DNA methylation and the expression of ecologically-relevant genes related to DNA methylation, stress response, muscle and organ formation, while 4 °C had no effect on juveniles. Furthermore, DNA methylation changes were more marked in larvae previously acclimated to a different temperature. The expression of most genes was also affected by temperature in the larvae but not in juveniles. In conclusion, this work constitutes the first study of DNA methylation in fish showing that temperature increases of the magnitude predicted by the latest global warming models result in stage-dependent alterations in global DNA methylation and gene expression levels. This study, therefore, provides insights on the possible consequences of climate change in fish mediated by genome-wide epigenetic modifications.

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Section: Discussionsupporting

confidence: 89%

Section: Methodsmentioning

confidence: 99%

Small ocean temperature increases elicit stage-dependent changes in DNA methylation and gene expression in a fish, the European sea bass

Anastasiadi

Díaz

Piferrer

2017

Sci Rep

106

View full text Add to dashboard Cite

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“…For instance, epigenetic modifications affecting development and growth during cell differentiation along with changes in epigenome profile may act as a memory, predisposing individuals to certain disease conditions (Mirbahai & Chipman 2014). In marine organisms, changes in DNA methylation have been linked to alterations in the early development, metamorphosis, and growth of teleost fishes (Covelo-Soto et al 2015b, Morán & Pérez-Figueroa 2011, J.L. Zhao et al 2015.…”

Section: Epigenetic Biomonitoring Of Marine Population Parametersmentioning

confidence: 99%

Marine Environmental Epigenetics

Eirín‐López

Putnam

2019

Annu. Rev. Mar. Sci.

225

173

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Marine organisms' persistence hinges on the capacity for acclimatization and adaptation to the myriad of interacting environmental stressors associated with global climate change. In this context, epigenetics-mechanisms that facilitate phenotypic variation through genotype-environment interactions-are of great interest ecologically and evolutionarily. Our comprehensive review of marine environmental epigenetics guides our recommendations of four key areas for future research: the dynamics of wash-in and wash-out of epigenetic effects, the mechanistic understanding of the interplay of different epigenetic marks and the interaction with the microbiome, the capacity for and mechanisms of transgenerational epigenetic inheritance, and the evolutionary implications of the interaction of genetic and epigenetic features. Emerging insights in marine environmental epigenetics can be applied to critical issues such as aquaculture, biomonitoring, and biological invasions, thereby improving our ability to explain and predict the responses of marine taxa to global climate change. Expected final online publication date for the Annual Review of Marine Science Volume 11 is January 3, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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“…Genome-wide DNA methylation was assessed on coral hostenriched-DNA samples using an amplified polymorphism approach specific for DNA methylation states (Methylation Sensitive Amplified Polymorphism, MSAP (Reyna-Lopez et al, 1997;Xiong et al, 2013;Covelo-Soto et al, 2015). This method is based on the use of isoesquizomeric endonucleases, HpaII and MspI, with shared sequence targets (CCGG sites) but differential sensitivities to their DNA methylation.…”

Section: Genome-wide Dna Methylation Analysismentioning

confidence: 99%

Genome-Wide DNA Methylation Analysis Reveals a Conserved Epigenetic Response to Seasonal Environmental Variation in the Staghorn Coral Acropora cervicornis

et al. 2020

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Epigenetic modifications such as DNA methylation have been shown to participate in plastic responses to environmental change in a wide range of organisms, including scleractinian corals. Unfortunately, the current understanding of the links between environmental signals, epigenetic modifications, and the subsequent consequences for acclimatory phenotypic changes remain obscure. Such a knowledge gap extends also to the dynamic nature of epigenetic changes, hampering our ability to ascertain the magnitude and extent of these responses under natural conditions. The present work aims to shed light on these subjects by examining temporal changes in genomewide patterns of DNA methylation in the staghorn coral Acropora cervicornis in the island of Culebra, PR. During a 17-month period, a total of 162 polymorphic loci were identified using Methylation-Sensitive Amplified Polymorphism (MSAP). Among them, 83 of these restriction fragments displayed changes in DNA methylation that were significantly correlated to seasonal variation as determined mostly by changes in sea water temperature. Remarkably, the observed time-dependent variation in DNA methylation patterns is consistent across coral genets, coral source sites and sitespecific conditions studied. Overall, these results are consistent with a conserved epigenetic response to seasonal environmental variation. These findings highlight the importance of including seasonal variability into experimental designs investigating the role of epigenetic mechanisms such as DNA methylation in responses to stress.

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Does DNA methylation regulate metamorphosis? The case of the sea lamprey (Petromyzon marinus) as an example

Cited by 27 publications

References 42 publications

Small ocean temperature increases elicit stage-dependent changes in DNA methylation and gene expression in a fish, the European sea bass

Small ocean temperature increases elicit stage-dependent changes in DNA methylation and gene expression in a fish, the European sea bass

Marine Environmental Epigenetics

Genome-Wide DNA Methylation Analysis Reveals a Conserved Epigenetic Response to Seasonal Environmental Variation in the Staghorn Coral Acropora cervicornis

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