Does Dose to an Oral Mucosa Organ at Risk Predict the Duration of Grade 3 Mucositis after Intensity-modulated Radiotherapy for Oropharyngeal Cancer?

Yahya, S.; Benghiat, Helen; Tiffany, M.; Sanghera, Paul; Hartley, A.

doi:10.1016/j.clon.2016.08.009

Cited by 9 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oral mucositis represents one the more severe acute complications experienced by HNC patients and while it is considered a transient complication it has a considerable impact on quality of life in the acute phase. As of yet patient-reported evaluation of acute oral mucositis does not appear to be very common and grading in the reports identified in this review has been performed using CTCAE[32, 34, 39–43] and EORTC/RTOG[40, 44, 45] scales.…”

Section: Resultsmentioning

confidence: 99%

Revisiting the dose constraints for head and neck OARs in the current era of IMRT

Brodin

Tomé

2018

Oral Oncology

View full text Add to dashboard Cite

Head and neck cancer poses a particular challenge in radiation therapy, whilst being an effective treatment modality requires very high doses of radiation to provide effective therapy. This is further complicated by the fact that the head and neck region contains a large number of radiosensitive tissues, often resulting in patients experiencing debilitating normal tissue complications. In the era of intensity-modulated radiation therapy (IMRT) treatments can be delivered using non-uniform dose distributions selectively aimed at reducing the dose to critical organs-at-risk while still adequately covering the tumor target. Dose-volume constraints for the different risk organs play a vital role in one’s ability to devise the best IMRT treatment plan for a head and neck cancer patient. To this end, it is pivotal to have access to the latest and most relevant dose constraints available and as such the goal of this review is to provide a summary of suggested dose-volume constraints for head and neck cancer RT that have been published after the QUANTEC reports were made available in early 2010.

show abstract

Section: Resultsmentioning

confidence: 99%

Revisiting the dose constraints for head and neck OARs in the current era of IMRT

Brodin

Tomé

2018

Oral Oncology

View full text Add to dashboard Cite

show abstract

“…The relationship between OM and dosimetric data derived from different methods of delineation (oral cavity contour, mucosal surface contours, oral cavity surface contour, oral/oropharyngeal surface contour) had been studied without finding any relation between dosimetric parameters and the duration of grade 3 OM or duration of opiate use; however, a trend towards significance between duration of strong opiate use and pretreatment weight had been shown [ 51 ]. Spatial dose distribution should be taken into account in parallel with a dose–volume histogram to predict regions where more severe OM is expected (non-keratinized vs keratinized area).…”

Section: Treatment-related Confounding Factorsmentioning

confidence: 99%

Confounding factors in the assessment of oral mucositis in head and neck cancer

Lorini

Perri

Vecchio

et al. 2022

Support Care Cancer

View full text Add to dashboard Cite

Treatment of locally advanced head and neck carcinoma not amenable for surgical resection or resected with high-risk features is usually based on (chemo-)radiation treatment. Oral mucositis represents one of the main side effects of (chemo-)radiation, with an important impact on quality of life and causing approximately 20% of early interruption of treatment, leading to a suboptimal dose administered. Treatment and prevention of oral mucositis have a central role in the therapeutic pathways of head and neck cancer patients but remains quite challenging. Although extensive research is conducted to identify interventions for the management of mucositis, very few interventions had sufficient evidence to generate an international expert consensus. This may be partially explained by confounding factors that could influence the development and assessment of oral mucositis. Little is known about the confounding factors of oral mucositis, which, if not well balanced in an experimental study, could lead to non-solid results. The current paper aims to review the main oral mucositis confounding factors related to head and neck cancer patients.

show abstract

“…While most studies focused on the risk of developing oral mucositis, one study of 66 oropharyngeal cancer patients investigated whether the duration of grade 3 acute mucositis was related to the dose received by the oral mucosa, but failed to find a significant association. 42…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of Normal Tissue Complication Models Relevant to Standard Fractionation Radiation Therapy of the Head and Neck Region Published After the QUANTEC Reports

Brodin

Kabarriti

Garg

et al. 2018

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

There has recently been an increasing interest in model-based evaluation and comparison of different treatment options in radiation oncology studies. This is partly driven by the considerable technical advancements in radiation therapy of the last decade, leaving radiation oncologists with a multitude of options to consider. In lieu of randomized trials comparing all of these different treatment options for varying indications, which is unfeasible, treatment evaluations based on normal tissue complication probability (NTCP) models offer a practical alternative. The Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC) effort, culminating in a number of reports published in 2010, provided a basis for many of the since-implemented dose-response models and dose-volume constraints and was a key component for model-based treatment evaluations. Given that 7 years have passed since the QUANTEC publications and that patient-reported outcomes have emerged as an important consideration in recent years, an updated summary of the published radiation dose-response literature, which includes a focus on patient-reported quality of life outcomes, is warranted. Here we provide a systematic review of quantitative dose-response models published after January 1, 2010 for endpoints relevant to radiation therapy for head and neck cancer, because these patients are typically at risk for a variety of treatment-induced normal tissue complications.

show abstract

Does Dose to an Oral Mucosa Organ at Risk Predict the Duration of Grade 3 Mucositis after Intensity-modulated Radiotherapy for Oropharyngeal Cancer?

Cited by 9 publications

References 15 publications

Revisiting the dose constraints for head and neck OARs in the current era of IMRT

Revisiting the dose constraints for head and neck OARs in the current era of IMRT

Confounding factors in the assessment of oral mucositis in head and neck cancer

Systematic Review of Normal Tissue Complication Models Relevant to Standard Fractionation Radiation Therapy of the Head and Neck Region Published After the QUANTEC Reports

Contact Info

Product

Resources

About