Does elective neck dissection in T1/T2 carcinoma of the oral tongue and floor of the mouth influence recurrence and survival rates?

Kelner, Natalie; Vartanian, José Guilherme; Pinto, Clóvis Antônio Lopes; Coutinho‐Camillo, Cláudia Malheiros; Kowalski, Luiz Paulo

doi:10.1016/j.bjoms.2014.03.020

Cited by 41 publications

(50 citation statements)

References 23 publications

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“…Thirty‐nine studies assessed occult nodal metastasis in patients with cN0 T1 and T2 of oral SCC who underwent END (Table ), with five RCTs and 34 retrospective studies. The rate of occult metastasis in patients with cN0 ranged from 20.6% to 49% in the RCTs, and 7.3% to 39.2% in the retrospective series.…”

Section: Resultsmentioning

confidence: 99%

Management of N0 neck in early oral squamous cell carcinoma: A systematic review and meta‐analysis

et al. 2018

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Objective The role of elective neck dissection (END) in patients with stage I (T1N0) and II (T2N0) squamous cell carcinoma of the oral cavity remains a controversial topic. We investigate the need for END by establishing a true incidence of occult nodal disease as a function of T stage Data Sources MEDLINE, Google Scholar, Scopus. Review Methods Studies were selected using a set of inclusion and exclusion criteria. Meta‐analysis using a random‐effects model was employed to generate an odds ratio (OR) comparing the incidence of occult metastasis between T1 and T2 tumors, as well as regional recurrence rates between patients receiving END versus observation. Results Thirty‐nine publications comprising five randomized controlled trials and 34 retrospective studies were selected for inclusion, yielding over 4,300 patients for analysis. The overall incidence of occult nodal metastasis, weighted by study size, was found to be 23%. Patients with T2 tumors have a significantly higher odds of having occult nodal disease (OR: 2.6, 95% confidence interval [CI]: 2.0‐3.4) over patients with T1 tumors. We also demonstrate that for patients who are observed, the odds of recurrence are significantly higher (OR: 4.18, 95% CI: 2.78‐6.28) compared to those who undergo END, although statistically significant interstudy heterogeneity was observed. Conclusions END should be reserved for stage II tumors given the significantly higher rate of occult metastasis. Observation may be more appropriate for stage I cancers. Laryngoscope, 129:E284–E298, 2019

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Section: Resultsmentioning

confidence: 99%

Management of N0 neck in early oral squamous cell carcinoma: A systematic review and meta‐analysis

et al. 2018

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“…However, analysis of recent articles, especially those reporting large case series or meta‐analyses, seems to support elective/stadiative neck dissection as the recommended treatment given the remarkable rate of occult neck metastasis observed . The reported rate is variable, ranging from 7% to 42%, although most authors have reported that neck dissection also improves locoregional control in patients with N0 cancer …”

Section: Discussionmentioning

confidence: 99%

Oncologic safety of facial artery myomucosal flaps in oral cavity reconstruction

et al. 2015

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“…In previous studies of head and neck cancers, END has been shown to increase morbidity. These studies have recommended that, unless there is a clear survival benefit, END should not be advocated for . There has been a stark lack of consensus for the use of END in cancers of the maxillary sinus in previous studies .…”

Section: Introductionmentioning

confidence: 99%

The role of elective neck dissection in the treatment of maxillary sinus squamous cell carcinoma

et al. 2017

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Does elective neck dissection in T1/T2 carcinoma of the oral tongue and floor of the mouth influence recurrence and survival rates?

Cited by 41 publications

References 23 publications

Management of N0 neck in early oral squamous cell carcinoma: A systematic review and meta‐analysis

Management of N0 neck in early oral squamous cell carcinoma: A systematic review and meta‐analysis

Oncologic safety of facial artery myomucosal flaps in oral cavity reconstruction

The role of elective neck dissection in the treatment of maxillary sinus squamous cell carcinoma

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