Does endurance training prior to ovariectomy protect against myocardial contractility dysfunction in rats?

Costa, Sabrina Paula; Domingues, Talita Emanuela; Rodrigues, Cíntia Maria; Silva, Sara Barros; Magalhães, Caíque Olegário Diniz e; Costa-Pereira, Liliane Vanessa; Peixoto, Marco Fabrício Dias; Fonseca, Sueli Ferreira da; Honorato‐Sampaio, Kinulpe; Mendonça, Vanessa Amaral; Lacerda, Ana Cristina Rodrigues

doi:10.1016/j.exger.2021.111556

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…Moreover, a growing body of evidence has also proven several beneficial effects of physical exercise therapy in counteracting the deleterious effects of menopause in the skeletal and cardiac muscles. In previous studies, we and others found that exercise training improved the cardiovascular and cardiac function of OVX rats 5 – 7 . However, comparison effects of endurance exercise training versus estradiol (E2) replacement therapy after menopause on skeletal muscle mitochondrial profile and redox/inflammatory status have not been investigated to date.…”

Section: Introductionmentioning

confidence: 68%

The superior beneficial effects of exercise training versus hormone replacement therapy on skeletal muscle of ovariectomized rats

Silva

Honorato‐Sampaio

Costa

et al. 2022

Sci Rep

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Previous studies have highlighted the positive effects of Estradiol (E2) replacement therapy and physical exercise on skeletal muscle during menopause. However, the comparison effects of exercise training (ET) and estradiol replacement therapy during menopause on skeletal muscle have not been investigated to date. This study aimed to compare the effects of endurance exercise training versus E2 replacement therapy on mitochondrial density, redox status, and inflammatory biomarkers in the skeletal muscle of ovariectomized rats. Thirty female Wistar rats (12-week-old) were randomly assigned into three groups: Untrained ovariectomized rats (UN-OVX, n = 10); untrained ovariectomized rats treated with estradiol replacement therapy (E2-OVX); and, trained ovariectomized rats (TR-OVX). After ovariectomy, the E2-OVX rats were treated subcutaneously with E2 (implanted Silastic® capsule containing 360 μg of 17β-estradiol/mL) while the TR-OVX group performed an exercise training protocol (50–70% of maximal running speed on a treadmill, 60 min/day, 5 days/week for 8 weeks). After euthanasia, the soleus muscle was processed for histological and biochemical evaluations. Only exercise prevented the reduction of maximal oxygen consumption and increased mechanical efficiency (ME). While mitochondrial muscle density, total antioxidant capacity (FRAP), catalase (CAT) activity, and interleukin 10 levels were higher in TR-OVX, only OVX-E2 presented higher CAT activity and lower interleukin 6 levels. Endurance exercise training compared with E2 replacement therapy maintains the aerobic capacity improving the ME of OVX rats. In addition, only endurance exercise training raises the skeletal muscle mitochondrial content and tends to balance the redox and inflammatory status in the skeletal muscle of OVX rats.

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Section: Introductionmentioning

confidence: 68%

The superior beneficial effects of exercise training versus hormone replacement therapy on skeletal muscle of ovariectomized rats

Silva

Honorato‐Sampaio

Costa

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Many studies have highlighted the positive effects of estrogen replacement therapy during menopause 4,5 . Moreover, a growing body of evidence has also proven several bene cial effects of other therapeutic strategies, especially physical exercise, to counteract the deleterious effects of menopause on skeletal and cardiac muscle including a recent work of our team which evidenced bene cial effects in cardiovascular function aspects in isolated cardiac muscle 5,6,7 . However, a comparison of the effects of exercise training versus hormone replacement therapy after menopause on muscle mitochondrial pro le and redox/in ammatory status has not been investigated to date.…”

Section: Introductionmentioning

confidence: 99%

Comparative Effects of Physical Exercise and Estradiol Therapy on Mitochondrial Density, Redox and Inflammatory Status in the Skeletal Muscle of Ovariectomized Rats

Silva

Honorato‐Sampaio

Costa

et al. 2022

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Background Previous studies have highlighted the positive effects of estrogen replacement therapy during menopause. In addition, a growing body of evidence has also proven several beneficial effects of other therapeutic strategies, especially physical exercise, to counteract the deleterious effects of menopause on skeletal muscle. However, a comparison of the effects of exercise training versus hormone replacement therapy after menopause on muscle mitochondrial profile and redox/inflammatory status has not been investigated to date. The purpose of the study was to investigate the effects of endurance training versus estradiol therapy on mitochondrial density, redox status, and inflammatory biomarkers in the skeletal muscle of ovariectomized rats. Methods Thirty twelve weeks-old female Wistar rats were randomly assigned into three groups: Untrained ovariectomized rats (OVX-NAT); untrained ovariectomized rats with estrogen (ES) replacement (OVX-ER); and, trained ovariectomized rats (OVX-AT). After ovariectomy, The OVX-ER rats were treated with ES (subcutaneously implanted Silastic® capsule containing 360 µg of 17β-estradiol/mL) while the OVX-AT group performed a training protocol (50~70% of maximal running speed on a treadmill, 60 min/day, five days/week for eight weeks). All animals performed a maximal treadmill test before and after the training protocol. After euthanasia, the soleus muscle was processed for histological e biochemical evaluations. Results The maximal oxygen consumption (VO2max), mitochondrial muscle density, total antioxidant capacity (FRAP), catalase (CAT) activity, and interleukin 10 levels improved only in the OVX-AT group, while only the OVX-ER rats presented an increase in CAT activity and a decrease in interleukin 6 levels. Conclusions Both endurance exercise training and estradiol therapy improve redox and inflammatory balance in the skeletal muscle of ovariectomized rats; however, only exercise increases VO2max and mitochondrial muscle density.

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Prior aerobic physical training modulates neuropeptide expression and central thermoregulation after ovariectomy in the rat

Domingues

Magalhães

Szawka

et al. 2022

Molecular and Cellular Endocrinology

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Does endurance training prior to ovariectomy protect against myocardial contractility dysfunction in rats?

Cited by 3 publications

References 33 publications

The superior beneficial effects of exercise training versus hormone replacement therapy on skeletal muscle of ovariectomized rats

The superior beneficial effects of exercise training versus hormone replacement therapy on skeletal muscle of ovariectomized rats

Comparative Effects of Physical Exercise and Estradiol Therapy on Mitochondrial Density, Redox and Inflammatory Status in the Skeletal Muscle of Ovariectomized Rats

Prior aerobic physical training modulates neuropeptide expression and central thermoregulation after ovariectomy in the rat

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