Does erythrocyte infusion improve 3.2-km run performance at high altitude?

Pandolf, Kent B.; Young, Andrew; Sawka, Michael N.; Kenney, J L; Sharp, Mark W.; Cote, R. R.; Freund, B. J.; Valeri, C. R.

doi:10.1007/s004210050465

Cited by 12 publications

(8 citation statements)

References 16 publications

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“…Are the changes in oxygen tension sensed by endothelial receptors, and is the antagonistic vasoconstriction more pronounced at higher elevations due to a more marked erythropoiesis? This, in addition to other mechanisms suggested by Pandolf et al (1998) may account for the observed lack of bene®t of erythrocyte infusion at more extreme elevations. We hope that these comments stimulate further research and help to advance our understanding of the complicated mechanisms that control oxygen transport in man.…”

Section: Sirsmentioning

confidence: 82%

“…(Pandolf et al 1998). I would like to bring to your attention a number of inconsistencies with the original paper and raise some additional points regarding the control of oxygen transport to skeletal muscle.…”

Section: Sirsmentioning

confidence: 94%

“…In vitro experimentation has clearly demonstrated changes in blood¯ow during both hypoxic and hyperoxic insults such that oxygen delivery to active muscle remains the same as that observed in normoxia (Hogan and Welch 1986). Wolfel et al (1991) examined the regulation of systemic oxygen transport in vivo during exercise on acute ( <4 h) and chronic (21 days) exposure to an identical inspired oxygen tension as that encountered in the study of Pandolf et al (1998) (»87 mmHg). Relative to acute ascent values, c a O 2 increased by »20% during acclimatisation.…”

Section: Sirsmentioning

confidence: 96%

“…Whilst we acknowledge the logistical technicalities associated with blood doping, one cannot ignore the importance of statistical power when designing an experiment. Based on our calculations and, in accordance with the methods outlined by Altman (1980), the study of Pandolf et al (1998) would have required 15 subjects per group to yield an acceptable power (1Ab) of 0.8 at the P < 0.05 level.…”

Section: Sirsmentioning

confidence: 98%

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Does erythrocyte infusion improve 3.2-km run performance at high altitude?

Bailey

1999

Eur J Appl Physiol

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Section: Sirsmentioning

confidence: 82%

Section: Sirsmentioning

confidence: 94%

Section: Sirsmentioning

confidence: 96%

Section: Sirsmentioning

confidence: 98%

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Does erythrocyte infusion improve 3.2-km run performance at high altitude?

Bailey

1999

Eur J Appl Physiol

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“…; Pandolf et al. ). However, these hematological adjustments also have the potential to influence the parameters used to generate the Athlete Biological Passport (Sottas et al.…”

Section: Introductionmentioning

confidence: 98%

Variability in human plasma volume responses during high‐altitude sojourn

et al. 2019

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When sea‐level ( SL ) residents rapidly ascend to high altitude ( HA ), plasma volume ( PV ) decreases. A quantitative model for predicting individual %∆ PV over the first 7 days at HA has recently been developed from the measurements of %∆ PV in 393 HA sojourners. We compared the measured %∆ PV with the %∆ PV predicted by the model in 17 SL natives living 21 days at HA (4300 m). Fasting hematocrit (Hct), hemoglobin (Hb) and total circulating protein ( TCP ) concentrations at SL and on days 2, 7, 13, and 19 at HA were used to calculate %∆ TCP and %∆ PV . Mean [95% CI ] measured %∆ PV on HA 2, 7, 13 and 19 was −2.5 [−8.2, 3.1], −11.0 [−16.6, −5.5], −11.7 [−15.9, −7.4], and −16.8 [−22.2, −11.3], respectively. %∆ PV and %∆ TCP were positively correlated ( P < 0.001) at HA 2, 7, 13, and 19 ( r 2 = 0.77, 0.88, 0.78, 0.89, respectively). The model overpredicted mean [95% CI ] decrease in %∆ PV on HA 2 (−12.5 [−13.9, −11.1]) and HA 7 (−21.5 [−23.9, −19.1]), accurately predicted the mean decrease on HA 13 (−14.3, [−20.0, −8.7]), and predicted a mean increase in %∆ PV on HA 19 (12.4 [−5.0, 29.8]). On HA 2, 7, 13, and 19 only 2, 2, 6, and 1, respectively, of 17 individual measures of %∆ PV were within 95% CI for predicted %∆ PV . These observations indicate that PV responses to HA are largely oncotically mediated, vary considerably among individuals, and available quantitative models require refinement to predict %∆ PV exhibited by individual sojourners.

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Red Blood Cell Volume and the Capacity for Exercise at Moderate to High Altitude

Jacobs

Lundby

Robach³

et al. 2012

Sports Med

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Hypoxia-stimulated erythropoiesis, such as that observed when red blood cell volume (RCV) increases in response to high-altitude exposure, is well understood while the physiological importance is not. Maximal exercise tests are often performed in hypoxic conditions following some form of RCV manipulation in an attempt to elucidate oxygen transport limitations at moderate to high altitudes. Such attempts, however, have not made clear the extent to which RCV is of benefit to exercise at such elevations. Changes in RCV at sea level clearly have a direct influence on maximal exercise capacity. Nonetheless, at elevations above 3000 m, the evidence is not that clear. Certain studies demonstrate either a direct benefit or decrement to exercise capacity in response to an increase or decrease, respectively, in RCV whereas other studies report negligible effects of RCV manipulation on exercise capacity. Adding to the uncertainty regarding the importance of RCV at high altitude is the observation that Andean and Tibetan high-altitude natives exhibit similar exercise capacities at high altitude (3900 m) even though Andean natives often present with a higher percent haematocrit (Hct) when compared with both lowland natives and Tibetans. The current review summarizes past literature that has examined the effect of RCV changes on maximal exercise capacity at moderate to high altitudes, and discusses the explanation elucidating these seemingly paradoxical observations. DOI: https://doi.org/10.2165/11632440-000000000-00000Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-69166 Accepted Version Originally published at: Jacobs, Robert A; Lundby, Carsten; Robach, Paul; Gassmann, Max (2012). Red blood cell volume and the capacity for exercise at moderate to high altitude. Sports Medicine, 42 (8) clear. Certain studies demonstrate either a direct benefit or decrement to exercise capacity in 34 response to an increase or decrease, respectively, in RCV; whereas, other studies report Andean natives often present with a higher percent hematocrit (Htc) when compared to both 39 lowland natives and Tibetans. The current review summarizes past literature that has examined 40 the effect of RCV changes on maximal exercise capacity at moderate to high altitudes, and 41 discusses the explanation elucidating these seemingly paradoxical observations.

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Does erythrocyte infusion improve 3.2-km run performance at high altitude?

Cited by 12 publications

References 16 publications

Does erythrocyte infusion improve 3.2-km run performance at high altitude?

Does erythrocyte infusion improve 3.2-km run performance at high altitude?

Variability in human plasma volume responses during high‐altitude sojourn

Red Blood Cell Volume and the Capacity for Exercise at Moderate to High Altitude

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