Does estradiol have an impact on the dipeptidyl peptidase IV enzyme activity of the Prevotella intermedia group bacteria?

Fteita, Dareen; Könönen, Eija; Gürsoy, Mervi; Söderling, Eva; Gürsoy, Ulvi Kahraman

doi:10.1016/j.anaerobe.2015.09.002

Cited by 19 publications

(19 citation statements)

References 49 publications

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“…These result in a significant increase in the crevicular fluid flow rate and a concomitant rise at the concentration of proinflammatory cytokines as well as pregnancy‐associated sex hormones, favouring the overgrowth of gingivitis‐inducing microorganisms (Kornman & Loesche , Fteita et al. , Lima et al. , Wu et al.…”

Section: Aimmentioning

confidence: 99%

“…The putative etiological explanation has been ascribed to the manifestation of various histological, serological and immunological changes within the gingival tissues during pregnancy. These result in a significant increase in the crevicular fluid flow rate and a concomitant rise at the concentration of proinflammatory cytokines as well as pregnancy-associated sex hormones, favouring the overgrowth of gingivitis-inducing microorganisms (Kornman & Loesche 1980, Fteita et al 2015, Lima et al 2015, Wu et al 2015. Kornman and Loesche reported that in the second trimester of pregnancy the strongly increased recovery of Prevotella intermedia from inflamed gingival sites was correlated with increased plasma levels of estrogen and progesterone both providing a substitute for menadione an essential P. intermedia growth factor.…”

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confidence: 99%

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Regular consumption of Lactobacillus reuteri‐containing lozenges reduces pregnancy gingivitis: an RCT

Schlagenhauf

Jakob

Eigenthaler

et al. 2016

J Clinic Periodontology

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Aim: This randomized controlled trial assessed the impact of Lactobacillus reuteri on pregnancy gingivitis in healthy women. Materials and Methods: Forty-five healthy women (24 test/21 placebo) with pregnancy gingivitis in the third trimester of pregnancy were enrolled. At baseline Gingival Index (GI) and Plaque Index (PlI) were assessed at the Ramfjord teeth and venous blood taken for TNF-a analysis. Subsequently participants were randomly provided with lozenges to be consumed 2 9 daily until birth (approx. 7 weeks) containing ≥10 8 CFU L. reuteri ATCC PTA 5289 and ≥10 8 CFU L. reuteri DSM 17938 (test) or being devoid of L. reuteri (placebo). Within 2 days after birth recording of GI, PlI and blood sampling were repeated. Results: At baseline, mean GI and mean PlI did not differ significantly between both groups. In the test group mean TNF-a serum level was significantly (p < 0.02) lower than in the placebo group. At reevaluation, mean GI and mean PlI of the test group were both significantly (p < 0.0001) lower than in the placebo group. Mean TNF-a serum level did no longer differ significantly between the groups. Conclusions: The consumption of L. reuteri lozenges may be a useful adjunct in the control of pregnancy gingivitis. Ulrich

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Section: Aimmentioning

confidence: 99%

mentioning

confidence: 99%

Regular consumption of Lactobacillus reuteri‐containing lozenges reduces pregnancy gingivitis: an RCT

Schlagenhauf

Jakob

Eigenthaler

et al. 2016

J Clinic Periodontology

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“…and pre`gnancy has been widely reported [14,29]. Dareen Fteita and his colleague have reported that Prevotella nigrescens, Prevotella pallens and Prevotella aurantiaca, which are similar to Prevotella intermedia, have a higher relative abundance as estradiol levels increase during pregnancy [30].…”

Section: Discussionmentioning

confidence: 99%

Pregnancy-Related Ecological Shifts of Salivary Microbiota and its Association with Salivary Sex Hormones

Niu

Jiang

Gao

et al. 2020

Preprint

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Background: The interactions between hosts, oral microbiomes and microenvironments have been the subject of much research in recent years. Yet, whether the alterations in the host impact the oral microbiome is not understood well. The fluctuation of sex hormone levels during pregnancy is a dramatic change in the host, and is closely related to pregnancy-associated gingivitis. In this study, salivary estradiol and progesterone level were measured at three trimesters of pregnancy and after delivery (t1: ≤ 14weeks；t2: 20–25 weeks；t3: 33–37 weeks; t4: 42 days after delivery) from 11 pregnant and 7 non-pregnant volunteers, and their salivary microbiome were collected and profiled by 16S rDNA gene sequencing. Results: The diversity of the salivary microbiome increased significantly in t3, compared to the t1 (P<0.05), and a close parallel to the shift is found in the elevation of salivary sex hormones. Addionally, Capnocytophaga gingivalis, Peptoniphilus sp.oral taxon 386, Prevotella baroniae, Simonsiella muelleri and Lactobacillus reuteri were correlated to the fluctuation of sex hormone levels. Conclusions: The diversity of the salivary microbiome in pregnant women was elevated with the gestation weeks, which was found parallel to the changes in estradiol and progesterone levels in saliva. Rather than highly abundant bacteria, the low abundant bacteria were more vulnerable to the host impact.

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“…Intense research has improved our understanding of the roles of DPP-4 activity. However, the studies performed so far have only considered the DPP-4 activity of human cells without taking into account that certain fungi and bacteria, part of the human-associated microbial communities, can also exhibit this enzymatic activity (Wallace et al, 1997 ; Matos et al, 1998 ; Varmanen et al, 2000 ; Goldstein et al, 2001 ; Sanz and Toldra, 2001 ; Anastasiou et al, 2002 ; Glaser et al, 2002 ; Shibata et al, 2003 ; Walker et al, 2003 ; Cooper and Woods, 2009 ; Stressler et al, 2013 ; Fteita et al, 2015 , 2017 ; Üstün-Aytekin et al, 2016 ). Only one study has tackled this issue when describing that the DPP-4 activity of the fungus Blastomyces dermatitidis , an opportunistic pathogen that can colonize the lungs, cleaves chemokines with deleterious consequences for local infection (Sterkel et al, 2016 ).…”

Section: The Gut Microbiota Exhibits Dpp-4-like Activity That Could Bmentioning

confidence: 99%

“…The gut microbiota that permanently colonizes the gastrointestinal tract influences the host metabolism and immune function (Sommer and Bäckhed, 2013 ; Cani, 2017 ). The possible roles of DPP-4-like activity exhibited by the gut microbiota itself have never been investigated even if several references describe the existence of DPP-4 activity in Prevotella (Wallace et al, 1997 ; Shibata et al, 2003 ; Walker et al, 2003 ; Fteita et al, 2015 , 2017 ), and a counterpart activity to the DPP-4 (called Xaa-Pro dipeptidyl-peptidase or PepX activity) is found in Lactobacillus, Lactococcus , and Streptococcus . (Matos et al, 1998 ; Varmanen et al, 2000 ; Goldstein et al, 2001 ; Sanz and Toldra, 2001 ; Anastasiou et al, 2002 ; Glaser et al, 2002 ; Stressler et al, 2013 ; Üstün-Aytekin et al, 2016 ).…”

Section: The Gut Microbiota Exhibits Dpp-4-like Activity That Could Bmentioning

confidence: 99%

The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host Health

et al. 2018

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The Dipeptidyl peptidase-4 (DPP-4) activity influences metabolic, behavioral and intestinal disorders through the cleavage of key hormones and peptides. Some studies describe the existence of human DPP-4 homologs in commensal bacteria, for instance in Prevotella or Lactobacillus. However, the role of the gut microbiota as a source of DPP-4-like activity has never been investigated. Through the comparison of the DPP-4 activity in the cecal content of germ-free mice (GFM) and gnotobiotic mice colonized with the gut microbiota of a healthy subject, we bring the proof of concept that a significant DPP-4-like activity occurs in the microbiota. By analyzing the existing literature, we propose that DPP-4-like activity encoded by the intestinal microbiome could constitute a novel mechanism to modulate protein digestion as well as host metabolism and behavior.

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Does estradiol have an impact on the dipeptidyl peptidase IV enzyme activity of the Prevotella intermedia group bacteria?

Cited by 19 publications

References 49 publications

Regular consumption of Lactobacillus reuteri‐containing lozenges reduces pregnancy gingivitis: an RCT

Regular consumption of Lactobacillus reuteri‐containing lozenges reduces pregnancy gingivitis: an RCT

Pregnancy-Related Ecological Shifts of Salivary Microbiota and its Association with Salivary Sex Hormones

The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host Health

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