Does exercise program of endurance and strength improve health-related quality of life in persons living with HIV-related distal symmetrical polyneuropathy? A randomized controlled trial

Yakasai, Abdulsalam Mohammed; Maharaj, Sonill Sooknunan; Kaka, Bashir; Danazumi, Musa Sani

doi:10.1007/s11136-020-02500-x

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…Predictive variables for these studies, which largely focused on DSP were similar to earlier studies and included age, CD4 þ T-cell nadir and duration of infection. These studies also emphasized the substantial adverse impact of PNP on both employment and quality of life [31], findings that we also documented. However, the effects of prior exposure to neurotoxic nucleoside ART medications was not apparent in some of these studies despite a clear effect in our study.…”

Section: Discussionsupporting

confidence: 79%

Predictive variables for peripheral neuropathy in treated HIV type 1 infection revealed by machine learning

Johnson

Fujiwara

et al. 2021

Aids

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Objective: Peripheral neuropathies (PNPs) in HIV-infected patients are highly debilitating because of neuropathic pain and physical disabilities. We defined prevalence and associated predictive variables for PNP subtypes in a cohort of persons living with HIV.Design: Adult persons living with HIV in clinical care were recruited to a longitudinal study examining neurological complications.Methods: Each patient was assessed for symptoms and signs of PNP with demographic, laboratory, and clinical variables. Univariate, multiple logistic regression and machine learning analyses were performed by comparing patients with and without PNP.Results: Three patient groups were identified: PNP (n ¼ 111) that included HIVassociated distal sensory polyneuropathy (n ¼ 90) or mononeuropathy (n ¼ 21), and non-neuropathy (n ¼ 408). Univariate analyses showed multiple variables differed significantly between the non-neuropathy and PNP groups including age, estimated HIV type 1 (HIV-1) duration, education, employment, neuropathic pain, peak viral load, polypharmacy, diabetes, cardiovascular disorders, AIDS, and prior neurotoxic nucleoside antiretroviral drug exposure. Classification algorithms distinguished those with PNP, all with area under the receiver operating characteristic curve values of more than 0.80. Random forest models showed greater accuracy and area under the receiver operating characteristic curve values compared with the multiple logistic regression analysis. Relative importance plots showed that the foremost predictive variables of PNP were HIV-1 duration, peak plasma viral load, age, and low CD4 þ T-cell levels.Conclusion: PNP in HIV-1 infection remains common affecting 21.4% of patients in care. Machine-learning models uncovered variables related to PNP that were undetected by conventional analyses, emphasizing the importance of statistical algorithmic approaches to understanding complex neurological syndromes.

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Section: Discussionsupporting

confidence: 79%

Predictive variables for peripheral neuropathy in treated HIV type 1 infection revealed by machine learning

Johnson

Fujiwara

et al. 2021

Aids

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Exercise and Neuropathy: Systematic Review with Meta-Analysis

et al. 2021

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Medicinal Plants for the Treatment of Neuropathic Pain: A Review of Randomized Controlled Trials

Ahmadzadeh,

Pourali,

Mirheidari

et al. 2024

CPB

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Neuropathic pain is a disabling condition caused by various diseases and can profoundly impact the quality of life. Unfortunately, current treatments often do not produce complete amelioration and can be associated with potential side effects. Recently, herbal drugs have garnered more attention as an alternative or a complementary treatment. In this article, we summarized the results of randomized clinical trials to evaluate the effects of various phytomedicines on neuropathic pain. In addition, we discussed their main bioactive components and potential mechanisms of action to provide a better view of the application of herbal drugs for treating neuropathic pain.

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Does exercise program of endurance and strength improve health-related quality of life in persons living with HIV-related distal symmetrical polyneuropathy? A randomized controlled trial

Cited by 3 publications

References 23 publications

Predictive variables for peripheral neuropathy in treated HIV type 1 infection revealed by machine learning

Predictive variables for peripheral neuropathy in treated HIV type 1 infection revealed by machine learning

Exercise and Neuropathy: Systematic Review with Meta-Analysis

Medicinal Plants for the Treatment of Neuropathic Pain: A Review of Randomized Controlled Trials

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