Does exposure of pregnant women to epidemic respiratory syncytial virus affect the severity of bronchiolitis?

Ramos-Fernández, José Miguel; Hernández-Yuste, Alexandra; Gutiérrez‐Bedmar, Mario; Martínez, Ana María Cordón; Moreno-Pérez, David

doi:10.1016/j.eimce.2018.07.015

Cited by 3 publications

(5 citation statements)

References 29 publications

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“…21 Some researchers from Thailand have reported the MP infected rate of 8.2. 22 These indicates that the importance of MP in bronchiolitis are increasing. In our study, oxygen therapy are less required of bronchiolitis with MP, and comparing MP with other viruses bronchiolitis, children with MP bronchiolitis don't cause more severe symptoms.…”

Section: Discussionmentioning

confidence: 95%

“…18,19 A retrospective cohort study indicated that the reduced exposure of pregnant women to RSV epidemic contributed to more severe RSV-induced bronchiolitis in children under 6 months of age. 20 Therefore, RSV-induced bronchiolitis is common in 6 months age; this may be associated with the circulation of antibodies that are not associated with RSV infection during pregnancy. Further investigations are necessary to identify speci c susceptibility factors.…”

Section: Discussionmentioning

confidence: 99%

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Etiology, clinical characteristics and coinfection status of bronchiolitis in Suzhou

Tan

Jiang

et al. 2021

Preprint

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Background: Bronchiolitis is a clinical syndrome commonly encountered in practice, particularly among infants and young children. To investigate the prevalence of pathogens in hospitalized children with bronchiolitis and study the clinical characteristics of bronchiolitis with or without coinfections. Methods: We investigated the respiratory specimens and clinical data of 1012 children with bronchiolitis who were treated at the Children’s Hospital of Soochow University between November 2011 and December 2018. The nasopharyngeal aspirates were examined to detect viruses by direct immunofluorescence assay or polymerase chain reaction (PCR). Mycoplasma pneumoniae (MP) was tested by PCR and enzyme-linked immunosorbent assay. Results: Of the 1134 children less than 2 years with bronchiolitis, 122 were excluded by exclusion criteria. Causative pathogen was detected in 83.4% (842 of 1012). The majority of these (614 [72.9%] of 842) were single virus infection. The most common pathogens detected were respiratory syncytial virus (RSV) (44.4%), MP (15.6%), and human rhinovirus (HRV) (14.4%). Coinfection was identified in 13.5% (137 of 1012) of the patients. Coinfection included mixed virus infection and virus infection with MP infection. Children with single virus infection had a higher rate of oxygen therapy compared with single MP infection. Conclusions: The most common pathogen detected in children with bronchiolitis is RSV, followed by MP and HRV. Coinfection leads to a longer period of illness, increased severity of the symptoms and increased risk of hypoxemia.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Etiology, clinical characteristics and coinfection status of bronchiolitis in Suzhou

Tan

Jiang

et al. 2021

Preprint

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“…to affect the severity of disease in infants. 34 The only outcome that was significantly different between periods was the shorter LOS during the pandemic. The policies in our hospital have not been significantly modified between 2010 and 2019, and the main change since 2020 at the start of the COVID-19 pandemic was the recommendation against the use of nebulizers in the emergency department.…”

Section: Discussionmentioning

confidence: 99%

“…The influence of the immune response at different ages could have an impact on the severity of respiratory diseases and the risk of hospitalization 32 . It is also of note that due to the low circulation of RSV in the community during the pandemic, 33 the exposure of women during pregnancy was limited, possibly leading to a decreased passive transfer of immunity, which has been suggested to affect the severity of disease in infants 34 …”

Section: Discussionmentioning

confidence: 99%

Bronchiolitis before and after the SARS‐CoV‐2 pandemic: Twelve years of experience in a Spanish paediatric hospital

Guerrero-del-Cueto

Ramos-Fernández

Leiva-Gea

et al. 2023

Pediatric Pulmonology

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Introduction Acute bronchiolitis is the main cause of hospitalization in children under 2 years of age, with a regular seasonality, mostly due to the respiratory syncytial virus. Objectives To describe the epidemiology of bronchiolitis hospitalizations in our center in the last 12 years, and analyze the changes in clinical characteristics, microbiology, and adverse outcomes during the SARS‐CoV‐2 pandemic. Methods Observational study including patients admitted for bronchiolitis between April 2010 and December 2021 in a Spanish tertiary paediatric hospital. Relevant demographic, clinical, microbiological, and adverse outcome variables were collected in an anonymized database. The pandemic period (April 2020 to December 2021) was compared to 2010−2015 seasons using appropriate statistical tests. Results There were 2138 bronchiolitis admissions, with a mean of 195.6 per year between 2010 and 2019 and a 2−4‐month peak between November and March. In the expected season of 2020, there was a 94.4% reduction of bronchiolitis hospitalizations, with only 11 cases admitted in the first year of the pandemic. Bronchiolitis cases increased from the summer of 2021 during a 6‐month long peak, reaching a total of 171 cases. Length of stay was significantly shorter during the pandemic, but no differences were found in clinical and microbiological characteristics or other adverse outcomes. Conclusions The SARS‐CoV‐2 pandemic has modified the seasonality of bronchiolitis hospitalizations, with a dramatic decrease in cases during the expected season of 2020−2021, and an extemporaneous summer−autumn peak in 2021 with longer duration but similar patient characteristics and risk factors.

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“…We also noted that the percentage of RSV infection gradually decreased with age, which suggests that younger infants are more vulnerable to RSV disease; this is consistent with the findings of previous studies [ 20 , 21 ]. A retrospective cohort study indicated that the reduced exposure of pregnant women to RSV epidemic contributed to more severe RSV-induced bronchiolitis in children under 6 months of age [ 22 ]. Therefore, RSV-induced bronchiolitis is common in 6 months age; this may be associated with the circulation of antibodies that are not associated with RSV infection during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Etiology, clinical characteristics and coinfection status of bronchiolitis in Suzhou

Tan

Jiang

et al. 2021

BMC Infect Dis

View full text Add to dashboard Cite

Background Bronchiolitis is a clinical syndrome commonly encountered in practice, particularly among infants and young children. To investigate the prevalence of pathogens in hospitalized children with bronchiolitis and study the clinical characteristics of bronchiolitis with or without coinfections. Methods We investigated the respiratory specimens and clinical data of 1012 children with bronchiolitis who were treated at the Children’s Hospital of Soochow University between November 2011 and December 2018. The nasopharyngeal aspirates were examined to detect viruses by direct immunofluorescence assay or polymerase chain reaction (PCR). Mycoplasma pneumoniae (MP) was tested by PCR and enzyme-linked immunosorbent assay. Results Of the 1134 children less than 2 years with bronchiolitis, 122 were excluded by exclusion criteria. Causative pathogen was detected in 83.2% (842 of 1012). The majority of these (614 [72.9%] of 842) were single virus infection. The most common pathogens detected were respiratory syncytial virus (RSV) (44.4%), MP (15.6%), and human rhinovirus (HRV) (14.4%). Coinfection was identified in 13.5% (137 of 1012) of the patients. Coinfection included mixed virus infection and virus infection with MP infection. Children with single virus infection had a higher rate of oxygen therapy compared with single MP infection. Conclusions The most common pathogen detected in children with bronchiolitis is RSV, followed by MP and HRV. Coinfection leads to a longer period of illness, increased severity of the symptoms and increased risk of hypoxemia.

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Does exposure of pregnant women to epidemic respiratory syncytial virus affect the severity of bronchiolitis?

Cited by 3 publications

References 29 publications

Etiology, clinical characteristics and coinfection status of bronchiolitis in Suzhou

Etiology, clinical characteristics and coinfection status of bronchiolitis in Suzhou

Bronchiolitis before and after the SARS‐CoV‐2 pandemic: Twelve years of experience in a Spanish paediatric hospital

Etiology, clinical characteristics and coinfection status of bronchiolitis in Suzhou

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