Does Extended Surgery Influence Health-Related Quality of Life in Patients With Rectal Cancer?

Orsini, R.G.; Vermeer, T.A.; Traa, Marjan J.; Nieuwenhuijzen, Grard A. P.; Hingh, Ignace H. J. T. de; Rutten, H.J.T.

doi:10.1097/dcr.0000000000000292

Cited by 8 publications

(9 citation statements)

References 29 publications

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“…The rate of sexual inactivity among women in the APER population was high (71%), in accordance with previous studies . This could be due in part to age and relationship status, and a similar trend was seen in the reference population, but several studies have reported a significant decrease in sexual activity after rectal cancer treatment .…”

Section: Discussionsupporting

confidence: 89%

“…By clinical experience and review of previous literature [3,4,6,[8][9][10]19,20] the following variables were identified as potential risk factors for urogenital dysfunction 3 years after APE and were included in the statistical analysis: age, sex, marital status, comorbidity, ASA, (neo)adjuvant (chemo)radiotherapy, preoperative urogenital dysfunction, surgical method, extent of surgery, postoperative infection, local recurrence and stomarelated worries (only used in analysis for sexual dysfunction).…”

Section: Risk Factors For Urogenital Dysfunctionmentioning

confidence: 99%

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Urogenital function 3 years after abdominoperineal excision for rectal cancer

et al. 2018

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Section: Discussionsupporting

confidence: 89%

Section: Risk Factors For Urogenital Dysfunctionmentioning

confidence: 99%

Urogenital function 3 years after abdominoperineal excision for rectal cancer

et al. 2018

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“…Regarding HRQL after surgical resection for rectal cancer, two Dutch studies reported lower physical function and sexual function in older patients than younger patients [ 49 , 50 ]. However, a previous German study of 253 patients with rectal cancer reported both better sexual function and worse physical function, role function and global quality of life in older patients after surgical resection [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Health related quality of life after oesophagectomy: elderly patients refer similar eating and swallowing difficulties than younger patients

et al. 2015

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BackgroundOesophagectomy for cancer could be safe and worthwhile in selected older patients, but less is known about the effect of oesophagectomy on perceived quality of life of such delicate class of cancer patients. The aim of this study was to evaluate the impact of oesophagectomy for cancer in elderly patients in term of health-related quality of life.MethodsWe retrospectively evaluated all consecutive patients who underwent oesophagectomy for cancer at the Surgical Oncology Unit of the Veneto Institute of Oncology between November 2009 and March 2014. Quality of life was evaluated using EORTC C-30 and OES-18 questionnaires at admission, at discharge and 3 months after surgery. Adjusted multivariable linear mixed effect models were estimated to assess mean score differences (MDs) of selected aspects in older (≥70 years) and younger (<70 years) patients.ResultsAmong 109 participating patients, 23 (21.1 %) were at least 70 years old and 86 (78.9 %) were younger than 70 years. Global quality of life was clinically similar between older and younger patients over time (MD 4.4). Older patients reported clinically and statistically significantly worse swallowing saliva (MD 17.4, 95 % C.I. 3.6 to 31.2), choking when swallowing (MD 13.8, 95 % C.I. 5.8 to 21.8) and eating difficulties (MD 20.1 95 % C.I. 7.4 to 32.8) than younger patients only at admission.ConclusionsEarly health-related quality of life perception after surgery resulted comparable in older and younger patients. This result may also be due to some predisposition of the elderly to adapt to the new status.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-015-1647-5) contains supplementary material, which is available to authorized users.

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“…3–5 Estimates of the incidence of sexual dysfunction in RC survivors varies from 23%–69% in men and 19%–62% in women. 6 In a population-based study (N=21,802), 25.1% of RC survivors reported sexual dysfunction, and 13.9% reported difficulties with appearance and body image.…”

Section: Introductionmentioning

confidence: 99%

Sexual Function and Health-Related Quality of Life in Long-Term Rectal Cancer Survivors

Sun

Grant

Wendel

et al. 2016

The Journal of Sexual Medicine

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Introduction Sexual dysfunction is a treatment sequela in rectal cancer (RC) survivors. Differences in health-related quality of life (HRQOL) may occur based on ostomy status (permanent ostomy versus anastomosis). Aim To describe alterations in sexual function and HRQOL based on ostomy status in long-term (≥ 5 years) RC survivors. Methods RC survivors with an ostomy (N=181) or anastomosis (N=394) were surveyed using validated HRQOL and functional status tools. We compared sexuality outcomes between the ostomy and anastomosis group, and reported differences adjusted for clinical and demographic characteristics. Qualitative data from one open-ended question on survivors’ greatest challenges since their surgery were analyzed to explore sexuality, symptoms, and relationships. Main Outcome Measures Whether sexually active, satisfaction with sexual activity, and select sexual dysfunction items from the Modified City of Hope Quality of Life-Ostomy (mCOH-QOL-O). Results Survivors with a permanent ostomy were more likely to have been sexually inactive after surgery if it occurred before year 2000, and experience dissatisfaction with appearance, interference with personal relationships and intimacy, and lower overall HRQOL. Female RC survivors with an ostomy were more likely to have problems with vaginal strictures and vaginal pain after surgery that persisted at the time of survey (5+ years later). Radiation treatment, tumor stage, soilage of garments in bed, and higher Charlson-Deyo co-morbidity scores were negatively associated with outcomes. Six qualitative themes emerged: loss of and decreased sexual activity; psychological issues with sexual activity, physical issues with sexual activity; partner rejection; ostomy interference with sexual activity; and positive experiences with sexuality. Conclusions Sexual dysfunction is a common long-term sequela of RC treatment, with more problems observed in survivors with a permanent ostomy. This warrants widespread implementation of targeted interventions to manage sexual dysfunction and improve HRQOL for these survivors.

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Does Extended Surgery Influence Health-Related Quality of Life in Patients With Rectal Cancer?

Cited by 8 publications

References 29 publications

Urogenital function 3 years after abdominoperineal excision for rectal cancer

Urogenital function 3 years after abdominoperineal excision for rectal cancer

Health related quality of life after oesophagectomy: elderly patients refer similar eating and swallowing difficulties than younger patients

Sexual Function and Health-Related Quality of Life in Long-Term Rectal Cancer Survivors

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