Does family history of schizophrenia influence age at onset of schizophrenia?

Shimizu, Akinori; Kurachi, Masayoshi; Yamaguchi, Nariyoshi; Torii, Hosaku; Isaki, Kiminori

doi:10.1111/j.1600-0447.1988.tb06410.x

Cited by 13 publications

(6 citation statements)

References 7 publications

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“…We observed an insignificantly younger age at onset in males (23.2 B 8.0 years) than in females (26.5 B 10.8 years), which corresponds well to Leonhard's report of a mean age at onset of 23.0 years in males and 26.5 years in females [12]. That the age at onset in periodic catatonia is later than that in systematic catatonia does not contradict the equivocal results for differential age at onset in sporadic and familial cases within a broad spectrum of schizophrenias and chronic schizoaffective psychoses [4][5][6], but does confirm that a clinical differentiation of schizophrenia into distinct syndromes may yield more consistent results.…”

Section: Discussionsupporting

confidence: 74%

“…These gender differences appeared to evolve only in the paranoid subgroups, although markedly catatonic residual syndromes provided evidence of an increased prevalence of male probands [2]. With regard to gender differences, the age at onset was thought to be earlier or more homogenously distributed in familial cases than in sporadic cases of schizophrenia [4][5][6]. DeLisi et al [7] pointed to a correlation between the age at onset in affected sib-pairs and the lack of any gender differences in familial cases.…”

Section: Introductionmentioning

confidence: 99%

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Gender Differences and Age of Onset in the Catatonic Subtypes of Schizophrenia

Stöber¹,

Franzek²,

Haubitz³

et al. 1998

Psychopathology

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In a family study involving 139 probands with chronic DSM-III-R schizophrenia, catatonic type, 83 probands met the criteria for periodic catatonia and 56 probands those for systematic catatonia according to Leonhard. In the systematic catatonias, we found a low morbidity risk of 4.6% in first-degree relatives, an early age at first hospitalization and a high prevalence of affected males. In the light of our recent report of an association between maternal gestational infection and systematic schizophrenia, male fetuses exposed to midgestational infection seem to be particularly at risk of developing systematic catatonia. Periodic catatonia with a family morbidity risk of 26.9% affected both genders with equal frequency and showed no age-at-onset differences between the genders. We found a moderate inverse relationship between early-onset probands and an increased risk in relatives of 24.1% compared to 17.8% in late-onset probands. Our findings substantiate the hypothesis that periodic catatonia is a clinically homogenous disorder with a major gene effect and an age at onset which is to a large extent genetically determined.

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Gender Differences and Age of Onset in the Catatonic Subtypes of Schizophrenia

Stöber¹,

Franzek²,

Haubitz³

et al. 1998

Psychopathology

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“…Studies comparing age of onset in patients with and without a family history of schizophrenia have found mainly insignificant differences (4)(5)(6). Kendler et al (7) reviewed previously published studies and presented an analysis of three large samples.…”

Section: Introductionmentioning

confidence: 99%

Age of onset in familial and sporadic schizoph4.4.renia

Alda

Ahrens

Lit

et al. 1996

Acta Psychiatr Scand

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We have studied the gender and family history differences with regard to age of onset of schizophrenia. These differences have often been viewed as an important clue to the aetiology of the illness. Patients from three centres in Europe and Canada were included in the study. A sample of 1089 subjects was categorized according to the subject's sex, family history of schizophrenia, and the centre. The principal statistical method was analysis of variance. Patients with no family history of schizophrenia had a consistently higher average age of onset. This effect was seen in both male and female subjects across all three groups. These results support the relationship between familial risk and early onset, but no interaction of gender and family history was found.

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“…However, the relationship (if any) between risk for schizophrenia and the presence of other psychiatric disorders in the family is less clear. Whether age at onset of schizophrenia is related to a family history of the disorder has been investigated (Kendler et al , 1987, 1996; Shimizu et al , 1988; Kendler & MacLean, 1990; Pulver & Liang, 1991; Sham et al , 1994; Suvisaari et al , 1998), and although the findings have not been consistent there is some evidence that those with higher familial loading for schizophrenia also have an earlier age at onset of the disorder (Kendler & MacLean, 1990; Pulver et al , 1990; Suvisaari et al , 1998). We estimated the risk for schizophrenia associated with a range of psychiatric disorders in parents and siblings of cases with schizophrenia compared with matched controls, and investigated the interactions between family psychiatric history and age at first contact for schizophrenia.…”

mentioning

confidence: 99%

Family history of psychiatric disorders and age at first contact in schizophrenia: An epidemiological study

2002

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BackgroundThe risk for schizophrenia has been associated with a family history of this and other psychiatric disorders. The relationship between age at first contact and family history of psychiatric illness is not certain.AimsTo estimate the risks for schizophrenia associated with a range of psychiatric diagnoses in family members and to investigate the relationship between these risks and age at first contact for schizophrenia.MethodA nested case–control study design was employed. Psychiatric admission data and socio-economic data were available for 7704 cases admitted between 1981 and 1998 in Denmark, 192 590 gender- and age-matched controls, and for the parents and siblings of all subjects.ResultsControlling for socio-economic factors, risk for schizophrenia was associated with a family history of all psychiatric disorders except substance misuse and independently with a family history of suicide. The risk for schizophrenia associated with a family history of psychiatric disorders decreased as age at first contact increased.ConclusionsRisk for schizophrenia is associated with a range of psychiatric disorders in family members and these risks are not constant across the risk period.

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Does family history of schizophrenia influence age at onset of schizophrenia?

Cited by 13 publications

References 7 publications

Gender Differences and Age of Onset in the Catatonic Subtypes of Schizophrenia

Gender Differences and Age of Onset in the Catatonic Subtypes of Schizophrenia

Age of onset in familial and sporadic schizoph4.4.renia

Family history of psychiatric disorders and age at first contact in schizophrenia: An epidemiological study

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