Does first serum beta-human chorionic gonadotropin value prognosticate the early pregnancy outcome in an In-vitro fertilisation cycle?

Naredi, Nikita; Singh, Santosh Kumar; Sharma, Rajesh

doi:10.4103/jhrs.jhrs_50_16

Cited by 14 publications

(6 citation statements)

References 21 publications

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“…In an in vitro fertilization-embryo transfer study [5], the prediction accuracy of HCG was better than that of progestin (P = 0.015). Monitoring of serum β-HCG [9] on the 15th day after the transfer of a cleavage stage embryo (3 days post in vitro fertilization) showed that when β-HCG was <500 mIU/ml, the rates of biochemical pregnancy, ectopic pregnancy, and missed abortion were all higher than when β-HCG was 501-1000 mIU/mL. The number of viable pregnancies was significantly reduced in the low β-HCG group.…”

Section: Discussionmentioning

confidence: 99%

the Forecast of Weekly β-HCG and Progesterone for Early Pregnancy

Yang¹,

Duan²,

Yan³

et al. 2019

Preprint

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Background: Serum beta human chorionic gonadotropin (β-HCG) and progesterone levels are both monitored to assess the status of early pregnancy. Deviations from the expected levels of these hormones may indicate abnormal pregnancy. However; the relationship between progesterone levels and the magnitude of weekly β-HCG increases, as well as their combined predictive value for pregnancy outcome, is still debated. This study evaluated the predictive value of weekly serum β-HCG multiplication and progesterone levels on early pregnancy outcomes. Methods: This retrospective study reviewed patients with pregnancy confirmed by β-HCG in our hospital. Weekly β-HCG and progesterone levels were analyzed and ultrasonography was performed as necessary to determine outcomes at 13 weeks gestation. Results: There were 277 viable intrauterine pregnancies, 102 spontaneous abortions, and 59 ectopic pregnancies. At weeks 5-8, β-HCG was multiplied by 6.76, 6.21, 2.11, and 0.68 respectively. Logit models were established with the logarithm of HCG (LHCG) and progesterone as independent variables to predict viable intrauterine pregnancy. The sensitivity, specificity, and overall accuracy for the models were 85.9% and 90.3%, 44.72% and 72%, and 70.77% and 83.6%, respectively. When progesterone was ≥10 ng/ml, the sensitivity and specificity for predicting viable pregnancy were 90.25% and 72.04%, respectively. When progesterone was <10 ng/ml, the sensitivity and specificity for predicting ectopic pregnancy and complete abortion were 94.2% and 81.57%, respectively. Progesterone values were significantly different for viable pregnancy, abortion, and ectopic pregnancy (p<0.0001). A joint progesterone and LHCG model to predict viable pregnancy had 88.8% sensitivity, 75.2% specificity, and 83.8% overall prediction accuracy. Conclusion: Weekly β-HCG multiplication and progesterone levels can predict early pregnancy outcomes individually or jointly.

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Section: Discussionmentioning

confidence: 99%

the Forecast of Weekly β-HCG and Progesterone for Early Pregnancy

Yang¹,

Duan²,

Yan³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Because the date of conception with IVF is precise, a single measurement of serum β-hCG at 12 to 18 days following embryo transfer has been established as a reliable early indicator of pregnancy. [ 11 ] And biochemical pregnancy failure is usually defined as a serum β-hCG < 5 mIU/mL 14 days after embryo transfer without a visible gestational sac by TVS. [ 12 ] Here, we report a ruptured rectal ectopic pregnancy which was thought to a biochemical pregnancy failure at the first postoperative visit.…”

Section: Discussionmentioning

confidence: 99%

Rectal ectopic pregnancy after in vitro fertilization and embryo transfer: A case report

et al. 2022

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Rationale: Rectal ectopic pregnancy is an extremely rare abdominal pregnancy. This article presents a female underwent an unsuccessful in vitro fertilization which was misdiagnosed by serum beta-human chorionic gonadotropin (β-hCG) test and transvaginal ultrasonography. Twenty days later, a ruptured rectal ectopic pregnancy was confirmed by laparoscopy then the gestational tissue removed successfully.Patient concerns: A 32-year-old Chinese female was admitted to our hospital with complaining of symptoms, like gradual worsening of lower abdominal pain and dysuria. The abdominal ultrasonography revealed a sac-like mass in the posterior area to the uterus and a moderate amount of free fluid in the pelvic cavity. Forty days ago, she underwent a frozen embryo transfer. Twenty days ago, her serum β-hCG level was <5 mIU/mL and neither intrauterine nor ectopic pregnancy was detected by transvaginal ultrasonography. Then the procedure was thought to have resulted in biochemical pregnancy failure.

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“…In an in vitro fertilization-embryo transfer study [5], the prediction accuracy of HCG was better than that of progestin (P=0.015). Monitoring of serum β-HCG [9] on the 15th day after the transfer of a cleavage stage embryo (3 days post in vitro fertilization) showed that when β-HCG was <500 mIU/ml, the rates of biochemical pregnancy, ectopic pregnancy, and missed abortion were all higher than when β-HCG was 501-1000 mIU/mL. The number of viable pregnancies was signi cantly reduced in the low β-HCG group.…”

Section: Discussionmentioning

confidence: 99%

the Forecast of Weekly β-HCG and Progesterone for Early Pregnancy

Yang

Duan

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Serum beta human chorionic gonadotropin (β-HCG) and progesterone levels are both monitored to assess the status of early pregnancy. Deviations from the expected levels of these hormones may indicate abnormal pregnancy. However; the relationship between progesterone levels and the magnitude of weekly β-HCG increases, as well as their combined predictive value for pregnancy outcome, is still debated. This study evaluated the predictive value of weekly serum β-HCG multiplication and progesterone levels on early pregnancy outcomes. Methods: This retrospective study reviewed patients with pregnancy confirmed by β-HCG in our hospital. Weekly β-HCG and progesterone levels were analyzed and ultrasonography was performed as necessary to determine outcomes at 13 weeks gestation. Results: There were 277 viable intrauterine pregnancies, 102 spontaneous abortions, and 59 ectopic pregnancies. At weeks 5-8, β-HCG was multiplied by 6.76, 6.21, 2.11, and 0.68 respectively. Logit models were established with the logarithm of HCG (LHCG) and progesterone as independent variables to predict viable intrauterine pregnancy. The sensitivity, specificity, and overall accuracy for the models were 85.9% and 90.25%, 44.72% and 72.04%, and 70.77% and 83.6%, respectively. When progesterone was ≥10 ng/ml, the sensitivity and specificity for predicting viable pregnancy were 90.25% and 72.04%, respectively. When progesterone was <10 ng/ml, the sensitivity and specificity for predicting ectopic pregnancy and complete abortion were 94.2% and 81.57%78.86%, respectively. Progesterone values were significantly different for viable pregnancy, abortion, and ectopic pregnancy (p<0.0001). A joint progesterone and LHCG model to predict viable pregnancy had 88.8% sensitivity, 75.2% specificity, and 83.8% overall prediction accuracy.Conclusion: Weekly β-HCG multiplication and progesterone levels can predict early pregnancy outcomes individually or jointly.

show abstract

Does first serum beta-human chorionic gonadotropin value prognosticate the early pregnancy outcome in an In-vitro fertilisation cycle?

Cited by 14 publications

References 21 publications

the Forecast of Weekly β-HCG and Progesterone for Early Pregnancy

the Forecast of Weekly β-HCG and Progesterone for Early Pregnancy

Rectal ectopic pregnancy after in vitro fertilization and embryo transfer: A case report

the Forecast of Weekly β-HCG and Progesterone for Early Pregnancy

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