Does Fluoxetine Have Any Effect on the Cognition of Patients With Mild Cognitive Impairment?

Mowla, Arash; Mosavinasab, Masoud; Pani, Azadeh

doi:10.1097/jcp.0b013e31802e0002

Cited by 127 publications

(67 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As principais melhoras parecem associadas às funções de memória de trabalho (Dí-gitos e Sequência de Números e Letras), raciocínio abstrato (Raciocínio Matricial), atenção, concentração, velocidade de processamento cognitivo (Procurar Símbolos e Códigos) e raciocínio espacial (Cubos). Estudos têm relatado a capacidade da fluoxetina de induzir neurogênese no hipocampo, com consequente melhora cognitiva nas funções de memória (Li et al, 2009;Mowla, Mosavinasab, & Pani, 2007), o que parece sustentar os presentes achados. Teng, Humes, Nakata e Melzer (2008) e Ogren et al (2008) também já haviam apontado que a estimulação do sistema serotoninérgico aparentemente está relacionada à melhora da cognição.…”

Section: Resultsunclassified

Psicoterapia psicodinâmica e tratamento biológico com fluoxetina: comparação de resposta cognitiva em pacientes deprimidos

Bastos

Trentini

2013

Psic.: Teor. e Pesq.

View full text Add to dashboard Cite

RESUMO -A depressão é uma doença grave, com repercussões importantes no humor e na cognição. Tratamentos farmacológicos e/ou psicoterápicos estão comumente indicados. O presente estudo objetivou avaliar e comparar a cognição de pacientes deprimidos antes e após 12 meses de tratamento com fluoxetina ou psicoterapia psicodinâmica. Cento e oitenta pacientes foram divididos em dois grupos, e avaliados por meio da WAIS-III. Os resultados mostraram uma melhora significativa em diferentes subtestes da WAIS-III. A MANOVA indicou que há uma diferença significativa entre os grupos nas pontuações médias obtidas na reavaliação 12 meses após o início dos tratamentos. Os resultados sugerem que a psicoterapia psicodinâmica e a terapia com fluoxetina agem de forma diferente na cognição de pacientes deprimidos.Palavras-chave: psicoterapia psicodinâmica, fluoxetina, cognição, depressão Psychodynamic Psychotherapy and Biological Treatment with Fluoxetine: Comparison of Cognitive Response in Depressed PatientsABSTRACT -Depression is a serious illness with an important impact on humor and cognition. Pharmacological treatments and/or psychotherapy are commonly indicated. The present study aimed to compare cognition in adult patients diagnosed with depression before and after 12 months of treatment with fluoxetine or psychodynamic psychotherapy. One hundred and eighty depressed patients were divided into two treatment groups, and cognitively assessed with the WAIS-III. Results showed a significant improvement in different subtests of WAIS-III. MANOVA indicated that there is a significant difference between groups in the mean scores of the post-treatment assessment. The results suggest that psychodynamic psychotherapy and fluoxetine act differently on cognition of depressed patients.

show abstract

Section: Resultsunclassified

Psicoterapia psicodinâmica e tratamento biológico com fluoxetina: comparação de resposta cognitiva em pacientes deprimidos

Bastos

Trentini

2013

Psic.: Teor. e Pesq.

View full text Add to dashboard Cite

show abstract

“…Greater anterior cingulum pathology in people with MCI and AD has been associated with more irritability, agitation, dysphoria, apathy, and night time behavioral disturbances 94 . Serotonergic dysfunction is probably of particular relevance to NPS, including depression and aggression 95 , suggesting serotonergic drugs might theoretically treat NPS and reduce risk of progression; in one preliminary study fluoxetine improved cognition in people with MCI compared with placebo after 8 weeks 96 . We found that depressive symptoms predicted conversion from any type MCI to all cause dementia in epidemiological studies, but evidence from clinical studies was inconsistent.…”

Section: Discussionmentioning

confidence: 99%

Modifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Cooper¹,

Sommerlad²,

Lyketsos³

et al. 2015

AJP

449

314

View full text Add to dashboard Cite

Objectives: Public health campaigns encouraging early help-seeking have increased rates of Mild Cognitive Impairment (MCI) diagnosis in Western countries, but we know little about how to treat or prognosticate dementia outcomes in persons with MCI. Method: We searched electronic databases and references for longitudinal studies reporting potentially modifiable risk factors for incident dementia after MCI. Two authors independently evaluated study quality using a checklist. We meta-analysed findings from three or more studies. Results: We identified 76 eligible papers. Diabetes and prediabetes increased risk of conversion from amnestic MCI (aMCI) to Alzheimer's Dementia (AD); risk in treated versus untreated diabetes was lower in one study. Diabetes was also associated with increased risk of conversion from any type or non-amnestic MCI to all cause dementia. Metabolic syndrome and pre-diabetes predicted all cause dementia in people with aMCI and any type MCI respectively. Mediterranean diet decreased risk of conversion from aMCI to AD. Presence of neuropsychiatric symptoms or lower serum folate levels predicted conversion from any type MCI to all cause dementia, but less formal education did not. Depressive symptoms predicted conversion from any type MCI to dementia in epidemiological, but not clinical studies. Conclusions: Diabetes increased the risk of conversion to dementia. Other prognostic factors that are potentially manageable are pre-diabetes and the metabolic syndrome, neuropsychiatric symptoms and low dietary folate. Dietary interventions and interventions to reduce neuropsychiatric symptoms including depression, which increase conversion risk to dementia, may decrease incident dementia.

show abstract

“…The antidepressant fluoxetine is a powerful stimulant of hippocampal neurogenesis (Malberg et al, 2000) and improves memory deficits in patients with mild cognitive impairment (Mowla et al, 2007), and after traumatic brain injury (Horsfield et al, 2002). In animal models, fluoxetine-induced neurogenesis is associated with improved allocentric spatial learning and memory after ischaemic injury (Li et al, 2009), and restoration of deficits in spatial working memory after anti-mitotic treatment (ElBeltagy et al, 2010;Lyons et al, 2011a).…”

Section: Introductionmentioning

confidence: 99%

Fluoxetine restores spatial learning but not accelerated forgetting in mesial temporal lobe epilepsy

Barkas

Redhead

Taylor

et al. 2012

Brain

View full text Add to dashboard Cite

Learning and memory dysfunction is the most common neuropsychological effect of mesial temporal lobe epilepsy, and because the underlying neurobiology is poorly understood, there are no pharmacological strategies to help restore memory function in these patients. We have demonstrated impairments in the acquisition of an allocentric spatial task, in patients with unilateral hippocampal sclerosis. We also show that patients have accelerated forgetting of the learned spatial task and that this is associated with damage to the non-dominant hippocampal formation. We go on to show a very similar pattern of chronic allocentric learning and accelerated forgetting in a status epilepticus model of mesial temporal lobe epilepsy in rats, which is associated with reduced and abnormal hippocampal neurogenesis. Finally, we show that reversal of the neurogenic deficit using fluoxetine is associated with reversal of the learning deficit but not the accelerated forgetting, pointing to a possible dissociation in the underlying mechanisms, as well as a potential therapeutic strategy for improving hippocampal-dependant learning in patients with mesial temporal lobe epilepsy.

show abstract

Does Fluoxetine Have Any Effect on the Cognition of Patients With Mild Cognitive Impairment?

Cited by 127 publications

References 16 publications

Psicoterapia psicodinâmica e tratamento biológico com fluoxetina: comparação de resposta cognitiva em pacientes deprimidos

Psicoterapia psicodinâmica e tratamento biológico com fluoxetina: comparação de resposta cognitiva em pacientes deprimidos

Modifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Fluoxetine restores spatial learning but not accelerated forgetting in mesial temporal lobe epilepsy

Contact Info

Product

Resources

About