Does formalin fixation influence MSCT/CBCT accuracy?

Seidel, Anna; Bergauer, Bastian; Lell, Michael; Buder, Thomas; Wilmowsky, Cornelius von; Dach, Eva; Wichmann, Manfred; Matta, Ragai Edward

doi:10.1007/s00276-017-1908-x

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…With specimens embalmed in formalin for several years before this study, optical density might have decreased, irrespective of imaging modality [25]. While Seidel et al [26] found no substantial difference between the diagnostic accuracy of MDCT and CBCT scans of a cadaveric specimen with and without formalin fixation, particularly the long-term effects of such fixation are not fully understood. Moreover, despite the blinded evaluation of scans, readers might have become accustomed to the characteristic image traits of each scanner over the time of their reads.…”

Section: Discussionmentioning

confidence: 72%

3D cone-beam CT with a twin robotic x-ray system in elbow imaging: comparison of image quality to high-resolution multidetector CT

et al. 2020

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Background Elbow imaging is challenging with conventional multidetector computed tomography (MDCT), while cone-beam CT (CBCT) provides superior options. We compared intra-individually CBCT versus MDCT image quality in cadaveric elbows. Methods A twin robotic x-ray system with new CBCT mode and a high-resolution clinical MDCT were compared in 16 cadaveric elbows. Both systems were operated with a dedicated low-dose (LD) protocol (equivalent volume CT dose index [CTDIvol(16 cm)] = 3.3 mGy) and a regular clinical scan dose (RD) protocol (CTDIvol(16 cm) = 13.8 mGy). Image quality was evaluated by two radiologists (R1 and R2) on a seven-point Likert scale, and estimation of signal intensity in cancellous bone was conducted. Wilcoxon signed-rank tests and intraclass correlation coefficient (ICC) statistics were used. Results The CBCT prototype provided superior subjective image quality compared to MDCT scans (for RD, p ≤ 0.004; for LD, p ≤ 0.001). Image quality was rated very good or excellent in 100% of the cases by both readers for RD CBCT, 100% (R1) and 93.8% (R2) for LD CBCT, 62.6% and 43.8% for RD MDCT, and 0.0% and 0.0% for LD MDCT. Single-measure ICC was 0.95 (95% confidence interval 0.91–0.97; p < 0.001). Software-based assessment supported subjective findings with less “undecided” pixels in CBCT than dose-equivalent MDCT (p < 0.001). No significant difference was found between LD CBCT and RD MDCT. Conclusions In cadaveric elbow studies, the tested cone-beam CT prototype delivered superior image quality compared to high-end multidetector CT and showed a potential for considerable dose reduction.

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Section: Discussionmentioning

confidence: 72%

3D cone-beam CT with a twin robotic x-ray system in elbow imaging: comparison of image quality to high-resolution multidetector CT

et al. 2020

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“…The resolution of the 3D data captured or imported into the software plays a crucial role in precision and needs to depict the object under investigation as precisely as possible. The method used in this study has been analysed in previous research, and the spatial resolution of CBCT images and the generated 3D models fall within an acceptable clinical range of <300 μm (Dach et al, 2018; Seidel et al, 2017). As all models were created in the same manner, they were directly comparable.…”

Section: Discussionmentioning

confidence: 99%

“…The deviations within the ROI were evaluated both linearly and volumetrically (Figure 2d–j). The used evaluation technique is a highly precise method for evaluating 3D digital data while avoiding errors made, for example, by manual measurements (Dach et al, 2018; Seidel et al, 2018; von Wilmowsky et al, 2015).…”

Section: Methodsmentioning

confidence: 99%

Three‐dimensional imaging analysis of CAD/CAM custom‐milled versus prefabricated allogeneic block remodelling at 6 months and long‐term follow‐up of dental implants: A retrospective cohort study

Seidel,

Leira,

Batalla

et al. 2024

J Clinic Periodontology

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AimThis retrospective cohort study aimed to volumetrically investigate the bone stability rate of prefabricated allogeneic bone blocks (PBB) and computer‐aided design (CAD)/computer‐aided manufacturing (CAM) custom‐milled allogeneic bone blocks (CCBB) for ridge augmentation.Materials and MethodsNineteen patients were treated with 20 allografts: 11 CCBB, 9 PBB; 10 in the maxilla and 10 in the mandible. Clinical treatment history and cone beam computed tomography scans before surgery (t0), directly after graft surgery (t1) and after 6 months of healing prior to implant insertion (t2) were evaluated using a three‐dimensional evaluation software for absolute bone volume, stability as well as vertical and horizontal bone gain. Furthermore, the inserted implants were analysed for survival, marginal bone loss (MBL) and complications for a mean follow‐up period of 43.75 (±33.94) months.ResultsA mean absolute volume of 2228.1 mm3 (±1205) was grafted at t1. The bone stability rate was 87.6% (±9.9) for CCBB and 83.0% (±14.5) for PBB. The stability was higher in the maxilla (91.6%) than in the mandible (79.53%). Surgery time of PBB was longer than for CCBB (mean Δ = 52 min). The survival rate of the inserted implants was 100% with a mean MBL of 0.41 mm (±0.37).ConclusionThe clinical performance of both allograft block designs was equally satisfactory for vertical and horizontal bone grafting prior to implant placement.Clinical Trial RegistrationClinicalTrials.gov: NCT06027710.

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“…The individual steps applied in this study were based on previous research that examined the accuracy of each step. The precision of the high-performance industrial optical scanner (Atos SO II, GOM GmbH) for digitising the impressions was 3 µm [ 34 ], and the accuracy of the converted 3D CBCT models was 400 (± 229) µm for 0.3 voxels [ 48 ]. The merging workflow was performed in a precise, two stage approach (manually and with a best-fit-algorithm), where images were registered by the tooth surfaces.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the palatal soft tissue volume: a 3D virtual analysis for digital workflows and presurgical planning

et al. 2022

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Background In mucogingival and implant surgery, an autologous soft tissue graft from the palate is the gold standard for reconstructing missing keratinised soft tissue and volume. Previously, presurgical measurements of the graft harvesting site were described with two-dimensional (2D) linear measurements. The present observational clinical study aimed to evaluate a three-dimensional (3D) measurement method for determining the present palatal soft tissue volume for each patient individually. Methods Pre-existing cone beam computed tomography (CBCT) scans of 20 patients were converted into 3D Standard Tessellation Language models of the bone surface. Intraoral impressions of the maxilla were taken and digitised to visualise the gingival surface. The resulting virtual models of bone (reference value) and gingival (actual value) surfaces were merged, with tooth surfaces used for registration. The region between the central incisors and the hard palate was subdivided into 5 regions of interest (ROIs). The distance between palatal bone and gingival surface was analysed both volumetrically and linearly, and the results were statistically evaluated for the ROIs. Results The average gingival surface area on the palate was 19.1 cm2, and the mean volume was 58.2 cm3 (± 16.89). Among the ROIs, the mean linear value was highest in the most distal region, from the second molar to the hard palate (4.0 ± 1.09 mm) and lowest in the canine region (1.9 ± 0.63 mm). For mean distance, significant differences were found for the anterior palate and the most posterior palate in comparison with all other ROIs (p < 0.01). The volume measurements also declined significantly and steadily between the posterior (1.9 ± 1.0 cm3) and anterior palates (0.4 ± 0.2 cm3). Conclusions By merging digital data, palatal soft tissue could be quantified virtually. The results were reliable and comparable to previous findings with linear measurement methods. This 3D soft tissue volume analysis method fully exploited the diagnostic potential of data that are frequently collected for presurgical planning in oral surgery (i.e., CBCT + surface scans). This evaluation method might be useful for volumetric and linear measurements in other applications in anatomy and for determining palatal soft tissue dimensions in the planning stage before surgical interventions. Trial registration This observational clinical trial was retrospectively registered in the German Clinical Trials Register, reference number: DRKS00023918.

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Does formalin fixation influence MSCT/CBCT accuracy?

Abstract: Our results suggest that formalin fixation of an anatomical specimen does not substantially affect the accuracy of a three-dimensional image generated with CBCT and MSCT. Thus, fixed specimen can be used in future investigations of 3D models without concerns regarding the accuracy.

Cited by 5 publications

References 30 publications

3D cone-beam CT with a twin robotic x-ray system in elbow imaging: comparison of image quality to high-resolution multidetector CT

3D cone-beam CT with a twin robotic x-ray system in elbow imaging: comparison of image quality to high-resolution multidetector CT

Three‐dimensional imaging analysis of CAD/CAM custom‐milled versus prefabricated allogeneic block remodelling at 6 months and long‐term follow‐up of dental implants: A retrospective cohort study

Investigation of the palatal soft tissue volume: a 3D virtual analysis for digital workflows and presurgical planning

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