Does garlic alter the lipid pattern in normal volunteers?

Saradeth, T.; S, Seidl; Resch, K. L.; Ernst, Edzard

doi:10.1016/s0944-7113(11)80062-0

Cited by 32 publications

(27 citation statements)

References 5 publications

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“…Similarly, one study conducted by Mader [20] in 1990 among patients suffering from dyslipidemia over a period of 16 weeks using 800 mg of garlic (standardized to 1.3% of Alliin) showed 12% reduction in serum cholestrol levels and 17% reduction in triglyceride levels in comparison to placebo; however, it was also noticed that the greatest cholesterol-lowering effects were seen in patients with initial total cholesterol values between 250 and 300 mg/dL. The results of this trial were somewhat contradicted by findings of a trial by Saradeth et al [26] where 600 mg of dried garlic powder (Kwai, Lichwer standardized to 1.3% alliin) was given to healthy patients with normal lipid levels over a period of 10 weeks. There was a significant reduction in total cholestrol and triglycerides levels confirming the fact that it can induce changes in blood lipids, even if these variables had been normal to start with Similarly another trial by Gadkari and Joshi on healthy medical students after consumption of 10 gm raw garlic showed significant reduction in serum cholesterol and increase in clotting time and fibrinolytic activity [27].…”

Section: Garlic Role In Dyslipidemiacontrasting

confidence: 60%

Role of Garlic Usage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Qidwai

Ashfaq

2013

Evidence-Based Complementary and Alternative Medicine

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Introduction. Rapidly growing prevalence of cardiovascular disease is a major threat for the developed as well as developing world warranting urgent need of intervention. Complementary and alternative medicines are gaining popularity among general population because of their safety profile and easy administration. Garlic, in particular, is considered to be one of the best disease-preventive foods because of its potent and widespread effects. This study was done to find out the role of garlic usage in cardiovascular disease prevention. Methodology. Major databases including Google, PubMed, MEDLINE, and Cochrane library view were used for the literature search. Clinical trials conducted on humans assessing role of garlic usage in cardiovascular disease prevention and the possible mechanisms responsible for such therapeutic actions were assessed. Results. Various clinical trials and meta-analyses conducted have shown positive impact of garlic in cardiovascular-disease prevention especially its effects on lipid levels; however, some contradictory results are also reported. Similarly, its effects on hypertension control, and platelet are also mild with limited data availability. The possible reason for these inconsistent results is the difference in preparations with diverse composition, variations in sulphur content present in different garlic preparations used, and methodological variations in subject recruitment, duration of study, dietary control and so forth. Conclusion. Garlic can be used as an adjuvant with lipid-lowering drugs for control of lipids, however, its role as a main therapeutic agent cannot be recommended and it is suggested that more meta-analyses using standardized preparations with a close watch on methodological shortfalls should be conducted to prove its role.

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Section: Garlic Role In Dyslipidemiacontrasting

confidence: 60%

Role of Garlic Usage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Qidwai

Ashfaq

2013

Evidence-Based Complementary and Alternative Medicine

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“…A total of 63 publications were assessed for eligibility (Figure ). A total of 39 trials fit inclusion criteria for meta‐analysis, of which 37 reported sufficient data on total cholesterol levels, 26 reported LDL cholesterol data, 30 reported HDL cholesterol data, and 32 reported triglyceride data (Table ) …”

Section: Resultsmentioning

confidence: 99%

“…87 The cholesterol-lowering properties of garlic have been linked to the inhibition of cholesterol synthesis 88,89 and the suppression of LDL oxidation. 90 A variety of Study Bordia (1981) 25 Sitprija et al (1987) 28 Plengvidhya et al (1988) 29 Vorberg & Schneider (1990) 32 Mader (1990) 31 Auer et al (1990) 30 Rotzsch et al (1992) 34 Phelps & Harris (1993) 37 DeASantos & Gruenwald (1993) 38 Jain et al (1993) 35 Saradeth et al (1994) 39 Simons et al (1995) 40 Neil et al (1996) 41 Adler & Holub (1997) 42 Bordia et al (1998) 45 Isaacsohn et al (1998) 46 Berthold et al (1998) 44 organosulfur components in garlic preparations may, to different degrees, exert cardiovascular effects/benefits. S-allylcysteine (commonly known by its abbreviation SAC) has been identified as the active and stable component in aged garlic extract, allowing standardization of preparations by S-allylcysteine dosage, but the active component in garlic powder is less well established, as the commonly named allicin, an alliin derivate, is volatile and is likely only transiently responsible for the cardiovascular effects.…”

Section: Discussionmentioning

confidence: 99%

Effect of garlic on serum lipids: an updated meta-analysis

2013

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Hypercholesterolemia is associated with an increased risk of heart disease. The effect of garlic on blood lipids has been studied in numerous trials and summarized in meta-analyses, with conflicting results. This meta-analysis, the most comprehensive to date, includes 39 primary trials of the effect of garlic preparations on total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. The findings suggest garlic to be effective in reducing total serum cholesterol by 17 ± 6 mg/dL and low-density lipoprotein cholesterol by 9 ± 6 mg/dL in individuals with elevated total cholesterol levels (>200 mg/dL), provided garlic is used for longer than 2 months. An 8% reduction in total serum cholesterol is of clinical relevance and is associated with a 38% reduction in risk of coronary events at 50 years of age. High-density lipoprotein cholesterol levels improved only slightly, and triglycerides were not influenced significantly. Garlic preparations were highly tolerable in all trials and were associated with minimal side effects. They might be considered as an alternative option with a higher safety profile than conventional cholesterol-lowering medications in patients with slightly elevated cholesterol.

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“…The studies by Williams et al ,52 Mader,10 Macan et al 14 and Kiesewetter et al 50 were included in the study by Reinhart et al , but were excluded in the current study, as these studies enrolled subjects suffering from diabetes mellitus,10, 50 taking lipid‐lowering drugs,50, 52 or gender difference between the garlic and placebo groups 14. We also added three studies23, 24, 42 omitted in Reinhart's review, but did not include four studies45, 46, 57, 58 due to incomplete data for statistical pooling. In addition, this study analyzed the effects of garlic on Apo‐B and TC/HDL‐C ratio.…”

Section: Discussionmentioning

confidence: 99%