Does Gastrin (Pentagastrin) Act Directly on the Parietal Cell in the Isolated Whole Stomach of the Mouse?

Szelenyi, Istvan; Thiemer, K

doi:10.1159/000137331

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…Without withdrawal of food and water, the continuous perfusion of the isolated stomach was mainly performed according to . A detailed description of the experimental procedure has been given in a preceding paper (Szelenyi and Thiemer, 1979). Exactly the same pro cedure was used in this study.…”

Section: Methodsmentioning

confidence: 99%

Cholinergic Pathway of Gastric Acid Secretion in the Isolated Whole Stomach of the Mouse

Szelenyi¹,

H²

1980

Pharmacology

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The isolated whole stomach of the mouse has been used to study the effect of atropine on gastric acid secretion stimulated by acetylcholine, bethanechol and histamine. Atropine inhibited acid secretory response to acetylcholine and bethanechol in a competitive manner. The following pA₂ values for atropine were calculated: 6.72, and 7.75, respectively. Slopes of log (DR-1) against log (B) were not significantly different from unity. Histamine-induced acid secretion was not inhibited by atropine. Acid secretory response to acetylcholine was not reduced by concentrations of cimetidine up to 10^–3 mol/l. Acetylcholine-induced acid secretion was not influenced by hexamethonium. In the mouse isolated stomach, acetylcholine stimulates acid secretion through a direct cholinergic pathway.

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Section: Methodsmentioning

confidence: 99%

Cholinergic Pathway of Gastric Acid Secretion in the Isolated Whole Stomach of the Mouse

Szelenyi¹,

H²

1980

Pharmacology

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“…This has been shown for the secretion, induced by gastrin or by vagal stimulation [1]. There are some data showing that even the secretion, evoked by direct stimulation of muscarinic receptors, can be diminished by HE-antagonists [2][3][4][5].…”

Section: Introductionmentioning

confidence: 86%

The effect of compound 48/80 on the carbachol-evoked acid secretion of the isolated mouse stomach

Stanovnik¹,

Erjavec²

1985

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The aim of the present work was to determine in the isolated mouse stomach whether the depletion of mast cell histamine by compound 48/80 influences the acid secretion, evoked by carbachol. Each effect of carbachol was compared to the effect of histamine (10(-6) M), applied after each carbachol application. After carbachol and histamine, compound 48/80 was applied twice or three times successively; the second and the third application were not able to evoke any secretion. After 48/80, the applications of carbachol and histamine were repeated and their effects compared to those before the applications of compound 48/80. Three concentrations of the compound were used: 20, 100 and 500 micrograms/ml. The lowest concentration of the histamine liberator did not significantly change the response to carbachol, The highest one reduced it but the effect of histamine was reduced, too. Compound 48/80 in concentration 100 micrograms/ml significantly augmented the secretory effect of carbachol. The possible explanation for this effect is that histamine, liberated from mast cells, is taken up by some other cells in the tissue from where it is liberated by carbachol stimulation.

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“…Nine experiments were performed for each preparation. For the acid secretion assay, isolated mouse stomach was used, as described by ANGUS and BLACK [5] and SZELEIqYI and THmMEa [6]. In this preparation, only one concentration of Hi and MeHi was assayed in the same organ in our experiments.…”

Section: Isolated Preparationsmentioning

confidence: 99%

Analysis of the dose-response relationship of histamine and Nτ-methylhistamine

Stanovnik

Erjavec

1982

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The dose-response relationship of histamine (Hi) and N tau-methylhistamine (MeHi) was analysed in isolated ileum and the right auricle of the guinea pig, in isolated mouse stomach and in the blood flow through the submandibular gland of the cat. It was shown that the intrinsic activity of MeHi is slightly less than that of Hi. MeHi is equally active on either type of Hi receptor; the differences found in the isolated mouse stomach and in the blood flow through the salivary gland can be explained by non-equilibrium conditions. The dissociation constant of MeHi (3.5 X 10(-4) M) is nearly the same in the isolated ileum and the right auricle of the guinea pig and in isolated mouse stomach.

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Does Gastrin (Pentagastrin) Act Directly on the Parietal Cell in the Isolated Whole Stomach of the Mouse?

Cited by 7 publications

References 11 publications

Cholinergic Pathway of Gastric Acid Secretion in the Isolated Whole Stomach of the Mouse

Cholinergic Pathway of Gastric Acid Secretion in the Isolated Whole Stomach of the Mouse

The effect of compound 48/80 on the carbachol-evoked acid secretion of the isolated mouse stomach

Analysis of the dose-response relationship of histamine and Nτ-methylhistamine

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