Does Glutamine Promote Benefits for Patients With Diabetes Mellitus Scheduled for Cardiac Surgery?

Ломиворотов, В. В.; Efremov, Sergey; Shmirev, Vladimir; Ponomarev, Dmitry; Svyatchenko, A.V.; Deryagin, Mihail N.; Ломиворотов, В. Н.; Karaskov, Alexander

doi:10.1016/j.hlc.2012.11.011

Cited by 6 publications

(15 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Six studies were conducted on diabetes type 2 patients [ 14 , 26 – 30 ], and one was conducted on the obese and diabetic subject [ 15 ]. Also, two studies examined the glutamine effect on diabetes type 1 patients [ 31 , 32 ]. Glutamine was generally supplemented by diluting in water and taken as a drink.…”

Section: Resultsmentioning

confidence: 99%

“…A high-dose glutamine supplementation led to postprandial glucose reduction [ 27 ]. In contrast, almost half of included studies showed no statistically significant improvement in glycemic status [ 19 , 20 , 22 – 24 , 26 , 29 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…Glutamine at both dosages significantly increased postprandial insulin response and glucagon levels; however, C-peptide levels were not affected [ 28 ]. In contrast, 4 weeks of glutamine supplementation (0.4 g/kg) did not show any significant changes in insulin resistance, insulin sensitivity, β-cell function, or blood glucose in patients with T1DM [ 31 ]. Also, administering 0.25 g/kg glutamine to adolescents did not change glycemic parameters such as insulin sensitivity or basal plasma free insulin concentration, except for blood glucose after 4 weeks in patients with T1DM [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

“…The results of this systematic review showed that glutamine supplementation has a potential effect on improving fasting plasma glucose [ 17 , 18 , 22 , 25 , 28 , 29 , 31 , 32 ], postprandial blood glucose [ 14 , 21 , 26 , 27 , 30 ], and significant increases in insulin production and incretin hormones such as GIP and GLP-1 [ 18 , 26 , 27 , 29 , 30 , 33 ]. However, results from insulin sensitivity were contradictory [ 31 , 32 ]. Regarding HbA1c and HOMA-IR, there is a lack of sufficient evidence to reach any conclusion.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

A comprehensive insight into the effect of glutamine supplementation on metabolic variables in diabetes mellitus: a systematic review

et al. 2020

View full text Add to dashboard Cite

Diabetes mellitus is one of the most important threats to human health in the twenty-first century. The use of complementary and alternative medicine to prevent, control, and reduce the complications of diabetes mellitus is increasing at present. Glutamine amino acid is known as a functional food. The purpose of this systematic review is to determine the potential role of glutamine supplementation on metabolic variables in diabetes mellitus. For this review, PubMed, SCOPUS, Embase, ProQuest, and Google Scholar databases were searched from inception through April 2020. All clinical trial and animal studies assessing the effects of glutamine on diabetes mellitus were eligible for inclusion. 19 studies of 1482 articles met the inclusion criteria. Of the 19 studies, nine studies reported a significant increase in serum GLP-1 levels. Also, eight studies showed reducing in serum levels of fasting blood sugar, four studies reducing in postprandial blood sugar, and triglyceride after glutamine supplementation. Although glutamine resulted in a significant increase in insulin production in seven studies, the findings on Hb-A1c levels were inconclusive. In addition to, despite of the results was promising for the effects of glutamine on weight changes, oxidative stress, and inflammation, more precise clinical trials are needed to obtain more accurate results. In conclusion, glutamine supplementation could improve glycemic control and levels of incretins (such as GLP-1 and GIP) in diabetes mellitus. However, more studies are needed for future studies.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A comprehensive insight into the effect of glutamine supplementation on metabolic variables in diabetes mellitus: a systematic review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…[55][56][57][58] Another approach is to augment CAC intermediates using anaplerotic precursors directly. Despite successfully increasing myocardial CAC intermediates, dipropionylcysteine ethyl ester and heptanoate failed to protect the myocardium, 59,60 in part, perhaps because of the differing protocols of drug infusion and myocardial ischemia.…”

Section: Downloaded Frommentioning

confidence: 99%

Citric Acid Cycle Intermediates in Cardioprotection

Czibik

Steeples

Yavari

et al. 2014

Circ Cardiovasc Genet

View full text Add to dashboard Cite

Abstract-Over the last decade, there has been a concerted clinical effort to deliver on the laboratory promise that a variety of maneuvers can profoundly increase cardiac tolerance to ischemia and/or reduce additional damage consequent upon reperfusion. Here we will review the proximity of the metabolic approach to clinical practice. Specifically, we will focus on how the citric acid cycle is involved in cardioprotection. Inspired by cross-fertilization between fundamental cancer biology and cardiovascular medicine, a set of metabolic observations have identified novel metabolic pathways, easily manipulable in man, which can harness metabolism to robustly combat ischemia-reperfusion injury. (Circ Cardiovasc Genet. 2014;7:711-719.)

show abstract

Does glutamine supplementation have favorable effects on glucose control and insulin sensitivity?

Kord‐Varkaneh

Salehi‐Sahlabadi

Mousavi

et al. 2019

NFS

View full text Add to dashboard Cite

Purpose The authors performed a systematic review and meta-analysis of all published randomized controlled trials with the aim to determine and quantify the anti-hyperglycemic effects of glutamine (Gln) in acute and chronic clinical settings. Design/methodology/approach The authors conducted a comprehensive search of all randomized clinical trials performed up to December 2018, to identify those investigating the impact of Gln supplementation on fasting blood sugar (FBS), insulin levels and homeostatic model assessment-insulin resistance (HOMA-IR) via ISI Web of Science, Cochrane library PubMed and SCOPUS databases. A meta-analysis of eligible studies was conducted using random effects model to estimate the pooled effect size. Fractional polynomial modeling was used to explore the dose–response relationships between Gln supplementation and diabetic indices. Findings The results of the present meta-analysis suggest that of Gln supplementation had a significant effect on FBS (weighted mean difference (WMD): –2.868 mg/dl, 95 per cent CI: –5.467, –0.269, p = 0.031). However, the authors failed to observe that Gln supplementation affected insulin levels (WMD: 1.06 units, 95 per cent CI: –1.13, 3.26, p = 0.34) and HOMA-IR (WMD: 0.001 units, 95 per cent CI: –2.031, 2.029, p = 0.999). Subgroup analyses showed that the highest decrease in FBS levels was observed when the duration of intervention was less than two weeks (WMD: –4.064 mg/dl, 95 per cent CI: –7.428, –0.700, p = 0.01) and when Gln was applied via infusion (WMD: –5.334 mg/dl, 95 per cent CI: –10.48, 0.17, p = 0.04). Originality/value The results from this meta-analysis show that Gln supplementation did not have a significant effect on insulin levels and HOMA-IR. However, it did significantly reduce the levels of FBS, obtaining a higher effect when the duration of the intervention period was less than two weeks.

show abstract

Does Glutamine Promote Benefits for Patients With Diabetes Mellitus Scheduled for Cardiac Surgery?

Cited by 6 publications

References 23 publications

A comprehensive insight into the effect of glutamine supplementation on metabolic variables in diabetes mellitus: a systematic review

A comprehensive insight into the effect of glutamine supplementation on metabolic variables in diabetes mellitus: a systematic review

Citric Acid Cycle Intermediates in Cardioprotection

Does glutamine supplementation have favorable effects on glucose control and insulin sensitivity?

Contact Info

Product

Resources

About