Does hand modulate the reshaping of the attentional system during rightward prism adaptation? An fMRI study

Abstract

Adaptation to right-deviating prisms (R-PA), that is, learning to point with the right hand to targets perceived through prisms, has been shown to change spatial topography within the inferior parietal lobule (IPL) by increasing responses to left, central, and right targets on the left hemisphere and decreasing responses to right and central targets on the right hemisphere. As pointed out previously, this corresponds to a switch of the dominance of the ventral attentional network from the right to the left hemisphere. Since the encoding of hand movements in pointing paradigms is side-dependent, the choice of right vs. left hand for pointing during R-PA may influence the visuomotor adaptation process and hence the reshaping of the attentional system. We have tested this hypothesis in normal subjects by comparing activation patterns to visual targets in left, central, and right fields elicited before and after adaptation to rightward-deviating prisms using the right hand (RWRH) with those in two control groups. The first control group underwent adaptation to rightward-deviating prisms using the left hand, whereas the second control group underwent adaptation to leftward-deviating prisms using the right hand. The present study confirmed the previously described enhancement of left and central visual field representation within left IPL following R-PA. It further showed that the use of right vs. left hand during adaptation modulates this enhancement in some but not all parts of the left IPL. Interestingly, in some clusters identified in this study, L-PA with right hand mimics partially the effect of R-PA by enhancing activation elicited by left stimuli in the left IPL and by decreasing activation elicited by right stimuli in the right IPL. Thus, the use of right vs. left hand modulates the R-PA-induced reshaping of the ventral attentional system. Whether the choice of hand during R-PA affects also the reshaping of the dorsal attentional system remains to be determined as well as possible clinical applications of this approach. Depending on the patients' conditions, using the right or the left hand during PA might potentiate the beneficial effects of this intervention.

Direction of visual shift and hand congruency enhance spatial realignment during visuomotor adaptation.

“…In summary, data across two experiments demonstrates that when the hand used to adapt and the direction of visual shift were congruent (i.e., left hand, left prisms or right hand, right prisms), it led to significantly larger aftereffects compared to incongruent adaptation conditions (i.e., left hand, right prisms or right hand, left prisms). Our results are partially supported by the behavioral data from a recent neuroimaging study by Farron and colleagues (Farron, Clarke, & Crottaz-Herbette, 2022) in which they observed larger PA aftereffects when participants adapted to rightward shifting prisms with the right hand (congruent), compared to rightward shifting prisms with the left hand (incongruent). Unfortunately, they did not test both hands with leftward shifting prisms.…”