Does Hashimoto's Thyroiditis Increase the Risk of Cardiovascular Disease in Young Type 1 Diabetic Patients?

Głowińska‐Olszewska, Barbara; Borysewicz-Sańczyk, Hanna; Sawicka, Beata; Klonowska, Bożenna; Charemska, Dorota; Żelazowska-Rutkowska, Beata; Bossowski, Artur

doi:10.3389/fendo.2020.00431

Cited by 18 publications

(14 citation statements)

References 68 publications

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“…The epidemiology and risk factors for microvascular and macrovascular complications in T1D patients have been extensively studied [7,8,9], but less attention has been paid to the presence of comorbid AIDs and their impact on the presence of complications. Additional autoimmune diseases may negatively affect metabolic control in patients with T1D [10,11], thereby potentially increasing the risk of micro or macrovascular complications. Furthermore, most autoimmune diseases confer an increased risk of cardiovascular disease [12,13], which could add to the already high baseline cardiovascular risk of T1D.…”

Section: Introductionmentioning

confidence: 99%

Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean area

Giménez-Pérez

Vlacho²,

Elena³

et al. 2022

Diabetes Research and Clinical Practice

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Section: Introductionmentioning

confidence: 99%

Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean area

Giménez-Pérez

Vlacho²,

Elena³

et al. 2022

Diabetes Research and Clinical Practice

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“…Most of these factors are overproduced with obesity. Conversely, levels of adiponectin are downregulated during obesity ( Tschritter et al, 2003 ; Lihn et al, 2005 ; Hajri et al, 2017 ; Głowinska-Olszewska et al, 2020 ; Skorepa et al, 2020 ). Wang et al’s (2019) results showed that high adiponectin is associated with stroke severity and support the hypothesis that adiponectin can serve as a biomarker of poor outcome after stroke, independent of baseline variables.…”

Section: Discussionmentioning

confidence: 99%

Associations between abdominal obesity and the risk of stroke in Chinese older patients with obstructive sleep apnea: Is there an obesity paradox?

Yang

et al. 2022

Front. Aging Neurosci.

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Background and purposeAbdominal obesity (AO) is a well-known independent risk factor for stroke in the general population although it remains unclear in the case of the elderly, especially in Chinese older patients with obstructive sleep apnea (OSA), considering the obesity paradox. This study aimed to investigate the association between AO and stroke among Chinese older patients with OSA.MethodsData were collected from January 2015 to October 2017, and 1,290 older patients (age 60–96 years) with OSA (apnea–hypopnea index ≥ 5 events/h on polysomnography) were consecutively enrolled from sleep centers at six hospitals, evaluated for AO defined as waist circumference (WC) using the standardized criteria for the Chinese population, and followed up prospectively for a median period of 42 months. Logistic regression and Cox regression analyses were used to determine the cross-sectional and longitudinal associations between AO and stroke risk in these participants and different groups of the severity of OSA.ResultsParticipants with AO had a higher prevalence of stroke at baseline. A higher incidence of stroke during a median follow-up period of 42 months in participants with AO than in participants without AO (12.4% vs. 6.8% and 8.3% vs. 2.4%, respectively; both P < 0.05) was predicted. Cross-sectional analysis revealed an association between AO and stroke (odds ratio [OR]1.96, 95% confidence interval [CI] 1.31–2.91), which was stronger among participants with moderate OSA only (OR 2.16, 95%CI 1.05–4.43). Cox regression analysis showed that, compared to participants without AO, participants with AO had a higher cumulative incidence of stroke (hazard ratio [HR] 2.16, 95% CI 1.12–4.04) during a median follow-up of 42 months, and this association was observed in patients with severe OSA only (HR 3.67, 95% CI 1.41–9.87) but not for individuals with mild OSA (HR = 1.84, 95% CI 0.43–6.23) and moderate OSA (HR = 1.98, 95% CI 0.73–6.45).ConclusionThe risk of stroke is associated with AO among Chinese older patients who have OSA, both at baseline and during follow-up, and the strength of the association varied by OSA severity. Active surveillance for early detection of AO could facilitate the implementation of stroke-preventive interventions in the Chinese older OSA population.

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“…The risk of stroke and myocardial infarction is 1.63 and 1.46 in T1D with AT and 1.28 and 1.33 in T1D with CD. The molecular mechanisms underlying this synergy are not yet known, although the chronic inflammation that characterizes autoimmune diseases has been partly held responsible [ 6 , 7 ]. From this perspective, patients with concomitant autoimmune diseases should receive a more intensive multifactorial treatment to prevent acute clinical events.…”

Section: Introductionmentioning

confidence: 99%

Autoimmune thyroiditis and celiac disease do not worsen endothelial function in subjects with type 1 diabetes: an observational study

Parise

Cutruzzolà

Scavelli

et al. 2022

Diabetol Metab Syndr

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Background Type 1 diabetes (T1D) is frequently associated with autoimmune thyroiditis (AT) and coeliac disease (CD). Whether the coexistence of multiple autoimmune diseases increases cardiovascular risk is uncertain. We evaluated the effects of AT and CD on arterial wall thickening and endothelial function in patients with T1D. Methods This observational study analyzed data from T1D patients regularly followed by the Diabetes Care Centre. Clinical and biochemical characteristics and micro and macrovascular complications were collected from the electronic medical records. All subjects performed Echo-Doppler to evaluate Intima-Media Thickness (IMT) of the common carotid artery (CCA) and endothelial function by the flow-mediated dilation (FMD) technique. The statistical analyses were performed by SPSS for Macintosh. Comparison between means was performed using the t-test for unpaired data and the Mann–Whitney U test. The ANalysis Of VAriance and the Tukey posthoc test were applied to compare patients with and without other autoimmune diseases, and control subjects. The p-value for statistical significance was set at p < 0.05. Results A total of 110 patients were enrolled. Among these, 69 had T1D and 41 T1D and AT and or CD, of whom 33 AT, 7 CD, and 1 both AT and CD. The mean age was 35 years, mean HbA1c was 7.6%, and mean diabetes duration 18 years. The IMT of the CCA was not significantly different between T1D patients with and without concomitant autoimmune diseases (with AT and CD: right CCA 603 ± 186 µ, left 635 ± 175 µ; without AT and CD: right CCA 611 ± 176 µ, left CCA 631 ± 200 µ). FMD was also comparable between T1D groups, with AT and CD 7.9 ± 4.2%; without AT and CD 8.8 ± 4.4%. Conclusion Patients with T1D and concomitant AT and or CD show no worse morphological or functional vascular damage, evaluated by CCA IMT and brachial artery flow-mediated dilation, than patients with T1D alone.

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Does Hashimoto's Thyroiditis Increase the Risk of Cardiovascular Disease in Young Type 1 Diabetic Patients?

Cited by 18 publications

References 68 publications

Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean area

Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean area

Associations between abdominal obesity and the risk of stroke in Chinese older patients with obstructive sleep apnea: Is there an obesity paradox?

Autoimmune thyroiditis and celiac disease do not worsen endothelial function in subjects with type 1 diabetes: an observational study

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