Does high-dose opioid anesthesia exacerbate ischemic spinal cord injury in rabbits?

Shirasawa, Yumiko; Matsumoto, Mishiya; Yoshimura, Manabu; Yamashita, Atsuo; Fukuda, Shiro; Ishida, Kazuyoshi; Sakabe, Takefumi

doi:10.1007/s00540-009-0741-8

Cited by 11 publications

(3 citation statements)

References 15 publications

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“…Motor function was assessed using a method previously described with some modification (Drummond and Moore, 1989;Kakinohana et al, 2006;Shirasawa et al, 2009). A motor deficit index (MDI) graded as follows was used: 0, normal; 1, toes flat under the body when walking, but ataxia present; 2, knuckle walking; 3, movement of This article has not been copyedited and formatted.…”

Section: Assessment Of Motor Functionmentioning

confidence: 99%

Sialorphin Potentiates Effects of [Met⁵]Enkephalin without Toxicity by Action other than Peptidase Inhibition

Kan

Yoshikawa

Watanabe

et al. 2020

J Pharmacol Exp Ther

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This dose-response study investigated the effects of sialorphin on [Met 5 ]enkephalin (ME)-induced inhibition of contractions in mouse vas deferens and antinociception in male rats. Differences were compared among combinations of three chemical peptidase inhibitors: amastatin, captopril, and phosphoramidon. The ratio of potencies of ME in mouse vas deferens pretreated with both sialorphin (100 !M) and a mixture of the three peptidase inhibitors (1 !M each) was higher than that with the mixture of peptidase inhibitors alone at any dose. Intrathecal administration of sialorphin (100 to 400 nmol) significantly and dose-dependently increased ME (3 nmol)-induced antinociception with the mixture of three peptidase inhibitors (10 nmol each). The degree of antinociception with a combination of any two of the peptidase inhibitors (10 nmol each) in the absence of sialorphin was less than that in the presence of sialorphin (200 nmol). Pretreatment with both sialorphin (200 nmol) and the mixture of three peptidase inhibitors (10 nmol each) produced an approximately 100-fold augmentation in ME (10 nmol)-induced antinociception, but without signs of toxicity such as motor dysfunction in rats. Radioligand receptor binding assay revealed that sialorphin did not affect either binding affinity or maximal binding capacity of DAMGO (D-Ala(2)-N-MePhe(4)-Gly-ol(5)-enkephalin). These results indicate that sialorphin potentiates the effects of ME without toxicity by a mechanism other than peptidase This article has not been copyedited and formatted. The final version may differ from this version.

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Section: Assessment Of Motor Functionmentioning

confidence: 99%

Sialorphin Potentiates Effects of [Met⁵]Enkephalin without Toxicity by Action other than Peptidase Inhibition

Kan

Yoshikawa

Watanabe

et al. 2020

J Pharmacol Exp Ther

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“…The researchers demonstrated that high-dose fentanyl and remifentanil do not exacerbate ischaemic spinal cord injury. This may be a significant finding because many patients in ICU such as those in our study have sustained CNS damage [22]. …”

Section: Discussionmentioning

confidence: 95%

Sedation and Analgesia in Intensive Care: A Comparison of Fentanyl and Remifentanil

Çevik¹,

Çelik

Clark

et al. 2011

Pain Research and Treatment

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Optimal sedation and analgesia are of key importance in intensive care. The aim of this study was to assess the quality of sedoanalgesia and outcome parameters in regimens containing midazolam and either fentanyl or remifentanil. A prospective, randomized, open-label, controlled trial was carried out in the ICU unit of a large teaching hospital in Istanbul over a 9-month period. Thirty-four patients were randomly allocated to receive either a remifentanil-midazolam regimen (R group, n = 17) or a fentanyl-midazolam regimen (F group, n = 17). A strong correlation between Riker Sedation-Agitation Scale (SAS) and Ramsey Scale (RS) measurements was observed. Comparatively, remifentanil provided significantly more potent and rapid analgesia based on Behavioral-Physiological Scale (BPS) measurements and a statistically nonsignificantly shorter time to discharge. On the other hand, remifentanil also caused a significantly sharper fall in heart rate within the first six hours of treatment.

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“…fentanyl nor i.v. remifentanil added to 0.5 MAC isoflurane exacerbated ischemic spinal cord injury in rabbits when compared to 1 MAC isoflurane [10]. In an experimental study, the authors determined whether morphine, administered via either the i.v.…”

Section: Opioids (Morphine Remifentanil and Fentanyl)mentioning

confidence: 99%

The Effect of Intravenous Anesthetics on Ischemia-Reperfusion Injury

Eroğlu

2014

BioMed Research International

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The effects of intravenous anesthetics on ischemia-reperfusion injury (IRI) have been investigated in both animals and clinical studies. The protective effects and the dosages of the intravenous anesthetics on IRI were discussed in this paper. The prevention of the tissue injury after the IRI was demonstrated with intravenous anesthetics in some studies. In the future, the studies should be focused on the dosage of the anesthetics related to diminishing the tissue injuries. Further studies might be required in order to investigate the effects of the anesthetics on molecular levels.

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Does high-dose opioid anesthesia exacerbate ischemic spinal cord injury in rabbits?

Abstract: Our results suggest that neither i.v. fentanyl nor i.v. remifentanil added to 0.5 MAC isoflurane exacerbated ischemic spinal cord injury in rabbits when compared to 1 MAC isoflurane.

Cited by 11 publications

References 15 publications

Sialorphin Potentiates Effects of [Met⁵]Enkephalin without Toxicity by Action other than Peptidase Inhibition

Sialorphin Potentiates Effects of [Met⁵]Enkephalin without Toxicity by Action other than Peptidase Inhibition

Sedation and Analgesia in Intensive Care: A Comparison of Fentanyl and Remifentanil

The Effect of Intravenous Anesthetics on Ischemia-Reperfusion Injury

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Does high-dose opioid anesthesia exacerbate ischemic spinal cord injury in rabbits?

Abstract: Our results suggest that neither i.v. fentanyl nor i.v. remifentanil added to 0.5 MAC isoflurane exacerbated ischemic spinal cord injury in rabbits when compared to 1 MAC isoflurane.

Cited by 11 publications

References 15 publications

Sialorphin Potentiates Effects of [Met5]Enkephalin without Toxicity by Action other than Peptidase Inhibition

Sialorphin Potentiates Effects of [Met5]Enkephalin without Toxicity by Action other than Peptidase Inhibition

Sedation and Analgesia in Intensive Care: A Comparison of Fentanyl and Remifentanil

The Effect of Intravenous Anesthetics on Ischemia-Reperfusion Injury

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Product

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Sialorphin Potentiates Effects of [Met⁵]Enkephalin without Toxicity by Action other than Peptidase Inhibition

Sialorphin Potentiates Effects of [Met⁵]Enkephalin without Toxicity by Action other than Peptidase Inhibition