This study investigates the interplay between research & development (R&D), human capital, foreign direct investment (FDI) and total factor productivity (TFP) in OECD.The analysis follows the endogenous growth theory and applies a panel data approach over the period 2000-2015. R&D and human capital have a positive effect on TFP, whilst FDI has a positive and significant effect only in the case of non-European countries. Moreover, the contribution of human capital is higher than that of R&D in European countries. On the other hand, the effect of R&D is higher than that of human capital and FDI in non-Europeans countries. Thus, based on these findings policies fostering R&D, higher education and investment should be a priority.