Does human activity impact the natural antibiotic resistance background? Abundance of antibiotic resistance genes in 21 Swiss lakes

Czekalski, Nadine; Sigdel, Radhika; Birtel, Julia; Matthews, Blake; Bürgmann, Helmut

doi:10.1016/j.envint.2015.04.005

Cited by 228 publications

(113 citation statements)

References 56 publications

Supporting

Mentioning

108

Contrasting

Unclassified

Order By: Relevance

“…Czekalski et al (2015) found that human activities strongly impact natural antibiotic resistance in the environment. However, the major factors contributing to the prevalence and fate of ARGs in urban rivers are largely unknown.…”

Section: Responsible Editor: Robert Duranmentioning

confidence: 99%

“…However, the major factors contributing to the prevalence and fate of ARGs in urban rivers are largely unknown. Several factors, including microbial community structure, environmental parameters, geographic factors, and anthropogenic activities, have been proposed to shape ARG profiles Forsberg et al 2014;Cabral et al 2016;Czekalski et al 2015).…”

Section: Responsible Editor: Robert Duranmentioning

confidence: 99%

See 1 more Smart Citation

Antibiotic resistance genes in an urban river as impacted by bacterial community and physicochemical parameters

Zhou

Zheng

Wei

et al. 2017

Environ Sci Pollut Res

144

View full text Add to dashboard Cite

Antibiotic resistance genes (ARGs) in urban rivers are a serious public health concern in regions with poorly planned, rapid development. To gain insights into the predominant factors affecting the fate of ARGs in a highly polluted urban river in eastern China, a total of 285 ARGs, microbial communities, and 20 physicochemical parameters were analyzed for 17 sites. A total of 258 unique ARGs were detected using high-throughput qPCR, and the absolute abundance of total ARGs was positively correlated with total organic carbon and total dissolved nitrogen concentrations (P < 0.01). ARG abundance and diversity were greatly altered by microbial community structure. Variation partitioning analysis showed that the combined effects of multiple factors contributed to the profile and dissemination of ARGs, and variation of microbial communities was the major factor affecting the distribution of ARGs. The disparate distribution of some bacteria, including Bacteroides from mammalian gastrointestinal flora, Burkholderia from zoonotic infectious diseases, and Zoogloea from wastewater treatment, indicates that the urban river was strongly influenced by point-source pollution. Results imply that microbial community shifts caused by changes in water quality may lead to the spread of ARGs, and point-source pollution in urban rivers requires greater attention to control the transfer of ARGs between environmental bacteria and pathogens.

show abstract

Section: Responsible Editor: Robert Duranmentioning

confidence: 99%

Section: Responsible Editor: Robert Duranmentioning

confidence: 99%

Antibiotic resistance genes in an urban river as impacted by bacterial community and physicochemical parameters

Zhou

Zheng

Wei

et al. 2017

Environ Sci Pollut Res

144

View full text Add to dashboard Cite

show abstract

“…Driven on chromosome or extra-chromosome or associated with mobile genetic element such as plasmids, integrons, genes cassettes or transposons, resistant genes are horizontal and vertical transferred from resistance to sensitive strains [25] causing the dissemination of antibiotic resistance within bacterial pathogen natural and hospital environment [19]. Spread of that kind of strains may create serious therapeutic problems in the future [26].…”

Section: Discussionmentioning

confidence: 99%

“…From nature, most potent molecule occurring β lactam were carbapenems and olixanic acids [17]. The natural environment may be the most important source of antibiotic resistance genes Czekalski et al [18], reported that freshwater aquatic environment represent a potential reservoir of antibiotic genes such as sulfamides, tetracycline and fluroquinolone resistant genes [19].…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Resistance Bacteria from Rivers Water in Algeria

Djenadi¹

2017

J Bacteriol Parasitol

View full text Add to dashboard Cite

The aim of the current investigation was to look on the presence of the antibiotic resistance bacteria in natural environment in Algeria. From fresh water, multidrug resistant bacteria were harvested, and then investigated for their resistance profile and extend spectrum Beta lactamase and metallo Beta lactamase production. From isolate bacteria only Aeromonas hydrophila catch our attention, because of their metallo Beta lactamase production and alimentary and clinical impact. This finding confirmed our hypothesis that natural environment could be colonized by multidrug resistant bacteria especially to carbapenem antibiotic who may be induced by mutation or horizontal gene transfer. The spread of these kinds of resistance organisms may become a serious issue for the public health and food security.

show abstract

“…[10] An investigation of the abundance of antibiotic resistance genes in 21 Swiss lakes using quantitative real-time PCR indicated higher abundance of certain of these genes with increasing number and capacity of wastewater treatment plants in the catchment. [11] Another approach to analyze microbial communities are the in situ analyses where the cells are kept intact by fixation techniques and the nucleic acids inside the cells are used for analysis. A combination of fluorescence in situ hybridization and flow cytometry made it possible, after multiple efforts of technique optimization, to extract ultramicrobacteria affiliated with LD12 Alphaproteobacteria from the rest of the microbial community in the water of the lake -an achievement that had not been possible until now with traditional techniques.…”

Section: Clinical Microbiologymentioning

confidence: 99%