Does human serotonin-1A receptor polymorphism (rs6295) code for pain and associated symptoms in fibromyalgia syndrome?

Abstract

Genetic predisposition may play an important role in the development of fibromyalgia syndrome (FMS). Serotonin is known to be involved in pain modulation and serotonin-1A receptor plays a considerable role in determining the central 5-HT tone. Consequently, variation in 5-HT1A receptor gene (HTR1A) may be responsible for inter-individual variability in pain sensitivity and other clinical symptoms of FMS. Therefore, the objectives of this research work were to study the gene polymorphism of 5-HTR1A gene and to explore the correlation between rs6295 genotype (−1019C/G HTR1A) and duration of pain, pain intensity and pain related depression and anxiety, if any, in FMS. 5-HTR1A genotype for the C(-1019)G polymorphism was typed in 62 patients with FMS and 42 healthy subjects. Present pain intensity, components of pain and pain related depression and anxiety were assessed using the numerical pain rating scale, McGill pain questionnaire and Hamilton depression and anxiety rating scale respectively. 5-HTR1A gene was represented by three different genotypes, homozygous C/C, heterozygous C/G and homozygous G/G. Analysis of the 5-HTR1A gene showed a frequency of 58%, 31% and 11% for the C/C, C/G and G/G genotypes, respectively in FMS group. This proportion was 69%, 23% and 8% in healthy subjects. No significant correlation was observed between 5-HTR1A gene polymorphism and pain and related symptoms in FMS patients. To the best of our knowledge this is the first study which investigated the correlation between the 5-HTR1A gene polymorphism and pain intensity, the affective component of pain, pain related depression and anxiety in FMS.

A significant association between rs2295190 polymorphism of the ESR1 gene and fibromyalgia syndrome

“…It was reported that there was a significant relationship between some polymorphisms of these genes and FMS (22). However, it was found that some polymorphisms in genes encoding μ-opioid receptor gene (OPRM1) (23), human serotonin-1A receptor (5-HTR1A) (24), and beta-2 adrenergic receptor (ADRB2) were not associated with FMS (25).…”

Can neural markers be used for fibromyalgia clinical management?

“…There's data pointing to 8.5 higher odds of familial aggregation in FM than in rheumatoid arthritis (Arnold et al, 2004) and an estimated sibling recurrence-risk ratio of 13.6 (Arnold et al, 2013). Several pain-related and non-related genes have been associated with FM (Tanwar, Mattoo, Kumar, Dada, & Bhatia, 2021), although none have been shown to consistently correlate to disease activity.…”

Serotonin Transporter mRNA Expression Is Reduced in the Peripheral Blood Mononuclear Cells of Subjects with Major Depression but Normal in Fibromyalgia

“…The involvement of 5-HT in pain modulation is of clear interest in the case of FM, considering that it is a chronic pain condition characterized by diffuse pain symptoms likely arising from deficient inhibitory conditioned pain modulation mechanisms [30]. So far, genetic studies that have examined the 5-HT 1A receptor and 5-HT 2A receptor gene polymorphisms, as well as studies measuring 5-HT blood levels, have produced mixed results [31][32][33]. In the case of the SERT, two genetic studies (one PET study and one study on gene expression) have also produced mixed results [34,35].…”