Does hyperbaric oxygen cause narcosis or hyperexcitability? A quantitative <scp>EEG</scp> analysis

Vrijdag, Xavier C. E.; Waart, Hanna van; Sames, C. Patrick; Mitchell, Simon J; Sleigh, Jamie

doi:10.14814/phy2.15386

Cited by 5 publications

(1 citation statement)

References 73 publications

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“…Обсуждение. В доступной литературе удалось найти сведения о сравнении системных и клеточных реакций организма на последовательное применение только гипероксического воздействия и действия повышенного давления азота [6,7]. В нашем случае мы использовали гипоксические воздействия для коррекции кислородного статуса организма методом пренатального прекондиционирования и показали влияние токсического действия азота на чувствительность крыс породы Wistar.…”

Section: Abstract: Marine Medicine Nitrogen Narcosis Hypoxic Stimulusunclassified

Modulating influence of wistar rats’ oxygen status on behavioural manifestations of nitrogen narcosis: experimental study

Vjotosh

Alekseeva

2023

Morsk. med.

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OBJECTIVE of the study is to determine the influence of changing oxygen status in the animal’s body on nitrogen toxic effect under pressure. MATERIALS AND METHODS: A hyperbaric chamber was used to create normothermic effect of hyperbaric nitrogen up to 4,1 MPa amid changing oxygen concentration from 0,03 to 0,004 MPa, recording rats’ motor activity and posture reflexes. RESULTS: Oxygen decrease in the respiratory gas medium from 0,021 to 0,004 MPa due to nitrogen compression raised biphasic sensitivity of Wistar rates to nitrogen toxic effect. Yet in the sites of non-compensable hypoxia sensitivity to hyperbaric nitrogen effect increased 4,5 times. Preliminary exposure of pregnant rats in hypoxia led to decrease in the offspring’s sensitivity to toxic effect of hyperbaric nitrogen by 35% on average after reaching puberty. DISCUSSION: The obtained data allows to regard toxic effect of hyperbaric nitrogen as oxygen-dependent process. While hypoxia along with hyperbaric nitrogen effect enhances nitrogen narcosis, hypoxia, prior to nitrogen compression, reduces intoxication of this gas.

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Section: Abstract: Marine Medicine Nitrogen Narcosis Hypoxic Stimulusunclassified

Modulating influence of wistar rats’ oxygen status on behavioural manifestations of nitrogen narcosis: experimental study

Vjotosh

Alekseeva

2023

Morsk. med.

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Disruptions in brain functional connectivity: The hidden risk for oxygen-intolerant professional divers in simulated deep water

Formaggio,

Pastena,

Melucci

et al. 2024

Biocybernetics and Biomedical Engineering

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Electroencephalographic (EEG) Changes Accompanying Normal Breathing of Concentrated Oxygen (Hyperoxic Ventilation) by Healthy Adults: A Systematic Review

Barnes,

Hallum,

Vrijdag

2024

Preprint

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Introduction:Divers often increase their fraction of inspired oxygen (FiO2) to decrease their risk of decompression sickness. However, breathing concentrated oxygen can cause hyperoxia, and central nervous system oxygen toxicity (CNS-OT). This study aims to review the literature describing hyperoxic ventilation's effect on the electroencephalogram (EEG), thus exploring the potential for real-time detection of impending CNS-OT seizure.Methods:We searched Medline, Embase, Scopus, and Web of Science for articles that reported EEG measures accompanying hyperoxic ventilation (FiO2= 1.0) in healthy participants. We included peer-reviewed journal articles, books, and government reports with no language or date restrictions. Randomised controlled trials and cross-over studies were included; case reports were excluded. We used the Newcastle-Ottawa scale to evaluate evidence quality.Results:Our search strategy returned 1025 unique abstracts; we analysed the full text of 40 articles; 22 articles (16 studies) were included for review. Study cohorts were typically small, and comprised of male non-divers. We discovered a variety of EEG analysis methods: studies performed spectral analysis (n = 12), the analysis of sensory-evoked potentials (n = 4), connectivity/complexity analysis (n = 3), source localization (n = 1), and expert qualitative analyses (n = 4). Studies of severe exposures (long duration at hyperbaric pressure) typically reported qualitative measures, and studies of mild exposures typically reported quantitative measures.Conclusions:There is a need for a large randomised controlled trial (RCT) reporting quantitative measures to better understand hyperoxic ventilation's effect on EEG, thus enabling the development of real-time monitoring of CNS-OT risk.

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Does hyperbaric oxygen cause narcosis or hyperexcitability? A quantitative EEG analysis

Cited by 5 publications

References 73 publications

Modulating influence of wistar rats’ oxygen status on behavioural manifestations of nitrogen narcosis: experimental study

Modulating influence of wistar rats’ oxygen status on behavioural manifestations of nitrogen narcosis: experimental study

Disruptions in brain functional connectivity: The hidden risk for oxygen-intolerant professional divers in simulated deep water

Electroencephalographic (EEG) Changes Accompanying Normal Breathing of Concentrated Oxygen (Hyperoxic Ventilation) by Healthy Adults: A Systematic Review

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