Does hypothermia play a relevant role in the glycemic alterations induced by ethanol?

Souza, Maria Lucia Oliveira; Masur, Jandira

doi:10.1016/0091-3057(82)90042-9

Cited by 21 publications

(4 citation statements)

References 13 publications

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“…For example, Risinger and Cunningham (in press) have recently reported that COLD mice show a greater hyperglycemic response to ethanol than HOT mice. On the basis of this finding and data suggesting that elevated ambient temperature enhances the hyperglycemic response to ethanol in rats (Souza and Masur 1982), they suggest that the apparent discrepancy between the rat and mouse studies may be resolved by focusing on differences in the glycemic response to ethanol.…”

Section: Taste Conditionin9mentioning

confidence: 81%

Assessment of ethanol's hedonic effects in mice selectively bred for sensitivity to ethanol-induced hypothermia

et al. 1991

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Mice selectively bred for sensitivity (COLD) or insensitivity (HOT) to the hypothermic effect of ethanol were tested in three tasks purported to assess ethanol's hedonic properties: place conditioning, taste conditioning, and ethanol drinking. In the place conditioning task, distinctive tactile (floor) stimuli were differentially paired with injection of ethanol (2.25 g/kg) or saline, and preference for the tactile stimuli was assessed during a choice test without ethanol. In the taste conditioning task, fluid-deprived mice were given repeated access to saccharin followed by injection of ethanol (2.25 g/kg). In the drinking task, mice were given access on alternate days to a single drinking tube containing water or ethanol in a concentration that gradually increased from 1 to 12% (v/v) over days. HOT mice showed greater conditioned preference for ethanol-paired flavor cues, and greater aversion for ethanol-paired flavor cues, and drank less ethanol at concentrations above 5% than COLD mice. HOT mice also showed higher levels of ethanol-stimulated activity than COLD mice. Control experiments indicated that the lines did not differ in initial preference for the tactile and flavor stimuli used in the conditioning tasks. Because the same line differences were seen in mice selected from two genetically independent populations, these studies offer strong evidence of genetic correlations between ethanol's thermal effect and its effect on activity, place conditioning and taste conditioning. Evidence of a genetic correlation between ethanol's thermal effect and ethanol drinking, however, is weaker since it is based on a line difference observed in only one of the genetic replicates. (ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Taste Conditionin9mentioning

confidence: 81%

Assessment of ethanol's hedonic effects in mice selectively bred for sensitivity to ethanol-induced hypothermia

et al. 1991

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“…The shift in the redox state supports a possible mechanism for the inhibition of hepatic gluconeogenesis (HGN) and corroborates the occurrence of alcohol-induced hypoglycemia, especially in malnourished individuals where renal and hepatic glycogen stores are compromised. While not a consistent observation, reports in fasted humans [5][6][7] and fasted rats [8][9][10] have demonstrated a significant decline in blood glucose concentration after a substantial ingestion of ethanol.…”

Section: Consumption On Glucose Homeostasismentioning

confidence: 95%

Sex Differences in Hepatic Gluconeogenic Capacity After Chronic Alcohol Consumption

Sumida

Hill

Matveyenko³

2007

Clinical Medicine & Research

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Alcohol-induced hypoglycemia has traditionally been attributed to the amount of ethanol consumed rather than any inherent decline in glucose output capacity by the gluconeogenic organs and/or an increase in skeletal muscle glucose uptake. Further, while the potential for sex differences that might impact glucose homeostasis following chronic alcohol consumption has been recognized, direct evidence has been noticeably absent. This paper will provide a brief review of past and present reports of the potential for sex differences in glucose homeostasis following chronic ethanol consumption. This paper will also provide direct evidence from our laboratory demonstrating sex differences from chronic alcohol consumption resulting in a decrement in glucose appearance and more importantly, a specific decline in hepatic gluconeogenic (HGN) capacity in the absence and presence of ethanol. All our studies involved 8 weeks of chronic alcohol consumption in male and female Wistar rats, as well as a 24 to 48 hour fast to deplete hepatic glycogen stores. Under the conditions of chronic alcohol consumption and an acute dose of ethanol, we provide in vivo evidence of an early decline in whole body glucose appearance in females fed an ethanol diet compared to controls.While the decline was also observed in males fed the alcohol diet, it occurred much later compared to ethanol fed females. The site for the decline in whole body glucose production (i.e., either the kidneys or the liver) was beyond the scope of our prior in vivo study. In a follow-up study using the in situ perfused liver preparation, we provide additional evidence for a specific reduction in HGN capacity from lactate in ethanol fed females compared to ethanol fed males in the absence of alcohol in the perfusion medium. Finally, employing the isolated hepatocyte technique, we report decrements in HGN from lactate in ethanol fed females compared to ethanol fed males in the presence of ethanol in the incubation medium.The mechanism for the specific decline in HGN within the liver of ethanol fed females remains to be determined.To the extent that our observations in animals can be extrapolated to humans, we conclude that alcoholic women are more susceptible to ethanol-induced hypoglycemia compared to alcoholic men.

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“…The main components of the marketed energy drinks are caffeine, taurine, carbohydrates, gluconolactone, inositol, niacin, pantenol, and B-complex vitamins. The effects of some of these components have been evaluated in the treatment of alcoholic intoxication, both for their influence on alcohol metabolism and for the symptoms of intoxication (Frezza et al, 1990;Souza and Masur, 1982;Wagner et al, 1976;Zimatkin et al, 1997).…”

mentioning

confidence: 99%

Effects of Energy Drink Ingestion on Alcohol Intoxication

Ferreira

Mello

Pompéia

et al. 2006

Alcoholism Clin & Exp Res

257

234

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Does hypothermia play a relevant role in the glycemic alterations induced by ethanol?

Cited by 21 publications

References 13 publications

Assessment of ethanol's hedonic effects in mice selectively bred for sensitivity to ethanol-induced hypothermia

Assessment of ethanol's hedonic effects in mice selectively bred for sensitivity to ethanol-induced hypothermia

Sex Differences in Hepatic Gluconeogenic Capacity After Chronic Alcohol Consumption

Effects of Energy Drink Ingestion on Alcohol Intoxication

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