Does Impaired Left Ventricular Relaxation Affect P Wave Dispersion in Patients with Hypertension?

Doğan, Abdullah; Özaydın, Mehmet; Nazli, Cem; Altınbaş, Ahmet; Gedikli, Omer; Kınay, Ozan; Ergene, Oktay

doi:10.1046/j.1542-474x.2003.08304.x

Cited by 19 publications

(16 citation statements)

References 22 publications

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“…If atrial fibrillation occurs, the loss of atrial systolic contribution to the left ventricular diastolic filling results in progressive diastolic dysfunction. Increased P-wave dispersion has been noted in hypertensive patients with diastolic dysfunction when compared with patients without diastolic dysfunction 10. Although some studies have suggested that left atrial diameter is an important predictor of atrial fibrillation, and that P-wave duration is related to left atrial dimension, the present study did not observe any relationship between P-wave dispersion and left atrial dimension 11,12…”

Section: Discussioncontrasting

confidence: 76%

P-wave dispersion : relationship to left ventricular function in sickle cell anaemia

Oguanobi

Onwubere²,

Ike³

et al. 2011

CardioVascular Journal of Africa

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BackgroundThe prognostic implications of P-wave dispersion in patients with a variety of cardiac disease conditions are increasingly being recognised. The relationship between P-wave dispersion and left ventricular function in sickle cell anaemia is unknown.ObjectiveThis study was aimed at evaluating the relationship between P-wave dispersion and left ventricular function in adult Nigerian sickle cell anaemia patients.MethodsBetween February and August 2007, a total of 62 sickle cell anaemia patients (aged 18–44 years; mean 28.27 ± 5.58) enrolled in the study. These were drawn from patients attending the adult sickle cell clinic of the University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu. An equal number of age- and gender-matched normal subjects served as controls. All the participants were evaluated with electrocardiography and echocardiography. P-wave dispersion was defined as the difference between the maximum and minimum P-wave duration measured in a 12-lead electrocardiogram.ResultsP-wave duration and P-wave dispersion were significantly higher in patients than in controls. Significant correlation was demonstrated between P-wave dispersion and age in the patients (r = 0.387; p = 0.031). A comparison of subsets of sickle cell anaemia patients and controls with comparable haematocrit values (30–35%) showed significantly higher P-wave duration and P-wave dispersion in the patients than in the controls. The P-wave duration in patients and controls, respectively, was 111.10 ± 14.53 ms and 89.14 ± 16.45 ms (t = 3.141; p = 0.006). P-wave dispersion was 64.44 ± 15.86 ms in the patients and 36.43 ± 10.35 ms in the controls (t = 2.752; p = 0.013). Significant negative correlation was found between P-wave dispersion and left ventricular transmitral E/A ratio (r = –0.289; p = 0.023).ConclusionThese findings suggest that P-wave dispersion could be useful in the evaluation of sickle cell patients with left ventricular diastolic dysfunction. Further prospective studies are recommended to evaluate its prognostic implication on the long-term disease outcome in sickle cell disease patients.

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Section: Discussioncontrasting

confidence: 76%

P-wave dispersion : relationship to left ventricular function in sickle cell anaemia

Oguanobi

Onwubere²,

Ike³

et al. 2011

CardioVascular Journal of Africa

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“…P wave dispersion (PWD) constitutes an important contribution to the field of noninvasive electrocardiology and is defined as the difference between the longest and shortest P wave duration recorded from surface electrocardiogram (ECG) leads. PWD has been thoroughly examined in a number of diseases including hypertension, coronary artery disease, coronary artery bypass surgery, and paroxysmal atrial fibrillation (AF) [3][4][5][6][7] . Therefore, it has been suggested that PWD can be used to diagnose patients with a high risk of AF [8][9][10][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

P wave dispersion is prolonged in patients with Wilson’s disease

Arat¹,

Kaçar²,

Gölbaşı³

et al. 2008

WJG

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AIM:To investigate the P wave dispersion as a noninvasive marker of intra-atrial conduction disturbances in patients with Wilson's disease. METHODS:We compared Wilson's disease patients (n = 18) with age matched healthy subjects (n = 15) as controls. The diagnosis was based on clinical symptoms, laboratory tests (ceruloplasmin, urinary and hepatic copper concentrations). P wave dispersion, a measurement of the heterogeneity of atrial depolarization, was measured as the difference between the duration of the longest and the shortest P-waves in 12 lead electrocardiography. RESULTS:All the patients were asymptomatic on cardiological examination and have sinusal rhythm in electrocardiography. Left ventricular and left atrial diameters, left ventricular ejection fraction and left ventricular mass index were similar in both groups. The Wilson's disease patients had a significantly higher P wave dispersion compared with the controls (44.7 ± 5.8 vs 25.7 ± 2.5, P < 0.01). CONCLUSION:There was an increase in P wave dispersion in cardiologically asymptomatic Wilson's disease patients which probably represents an early stage of cardiac involvement.

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“…Study conducted by Dogan et al 17 showed that impaired LV relaxation contributes to the heterogeneous atrial conduction in hypertensive patients and results in increased PWD.…”

Section: Discussionmentioning

confidence: 99%

Relationship between P Wave Dispersion and Left Ventricular Diastolic Dysfunction in Hypertensive and Ischemic Heart Disease Patients

et al. 2015

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Does Impaired Left Ventricular Relaxation Affect P Wave Dispersion in Patients with Hypertension?

Abstract: This study suggests that impaired LV relaxation contributes to the heterogeneous atrial conduction in hypertensive patients.

Cited by 19 publications

References 22 publications

P-wave dispersion : relationship to left ventricular function in sickle cell anaemia

P-wave dispersion : relationship to left ventricular function in sickle cell anaemia

P wave dispersion is prolonged in patients with Wilson’s disease

Relationship between P Wave Dispersion and Left Ventricular Diastolic Dysfunction in Hypertensive and Ischemic Heart Disease Patients

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