Does implantation site influence bone ingrowth into 3D-printed porous implants?

Walsh, William R.; Pelletier, Matthew H.; Wang, Tian; Lovric, Vedran; Morberg, Per; Mobbs, Ralph J.

doi:10.1016/j.spinee.2019.06.020

Cited by 41 publications

(41 citation statements)

References 51 publications

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“…Bone defects caused by trauma, infection, and tumour resection are common and seriously endanger bone healing [1][2][3][4]. Currently, porous titanium implants based on 3D printing have become a bone substitute because of their porous property and the open porous structure facilitates the transport of blood and nutrients in the implant, promoting tissue regeneration and reconstruction and speeds up the repair process [5][6][7][8][9][10]. However, the titanium surface has low bioactivity, forms a simple mechanical interlock with the bone tissue, and does not induce bone integration.…”

Section: Discussionmentioning

confidence: 99%

“…Allogeneic bone grafts have the risks of immune diseases and of slowing bone remodelling [1][2][3]. 3D-printed porous titanium (3D PPT) is a potential bone substitute material because of its porous structure simulating natural bone, which is beneficial to the growth of new bone tissue and provides a new way to treat bone defects [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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3D-printed titanium implant-coated polydopamine for repairing femoral condyle defects in rabbits

Zhong

et al. 2020

J Orthop Surg Res

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Background: Large segmental bone defects are still one of the challenges for orthopaedic surgeons. Although 3Dprinted porous titanium is a potential bone substitute material because of its porous structure simulating natural bone, the titanium surface has low bioactivity, integrates with bone tissue through the simple mechanical interlock. The study aims to investigate the capability and osteogenesis of 3D-printed porous titanium (3D PPT)-coated polydopamine (PDA) for repairing bone defects. Methods: Fifteen 6-month New Zealand white rabbits were implanted with PDA-3D PPT to repair 6 mm × 10 mm defects on the femoral condyle compared with the group of 3D PPT and comparing with the blank group. After 6 weeks and 12 weeks, micro-CT and histological examination were performed to observe bone growth. Results: All the PDA-3D PPT group, the 3D PPT group and the blank group recovered in good condition. The images showed that the boundaries between the implant area and the surrounding area were obscure in the three groups. The results of micro-CT demonstrated that at 6 weeks and 12 weeks, the bone volume (BV) values of PDA-3D PPT implants group were significantly higher than those of the 3D PPT implants group and blank group (P < 0.05), the BV/tissue volume (TV) and the trabecular number (Tb.N) of PDA-3D PPT implants were significantly higher than those of the 3D PPT group and blank group (P < 0.05). The results of un-decalcified bone slicing showed that ore new bone appeared to form around the PDA-3D PPT than that of 3D PPT and blank group. The bone-implant contact (BIC) of PDA-3D PPT was better (P < 0.05) than that of 3D PPT group. Conclusion: PDA-3D PPT could improve the bioactivity and promote the growth and healing of bone tissue and can be a promising repairing material.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

3D-printed titanium implant-coated polydopamine for repairing femoral condyle defects in rabbits

Zhong

et al. 2020

J Orthop Surg Res

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“…Both ends of the screw contain a threaded structure, and the middle part contains a porous metal structure. The design of the porous metal structure can increase cell adhesion and promote cell differentiation, and the porous metal structure can also facilitate bone ingrowth so that bone fusion can be completed without the implantation of autologous or allogeneic bone, and related complications in bone harvesting area can be reduced [11,47,48]. The pore size of the porous metal is 150 μm.…”

Section: Segmentmentioning

confidence: 99%

“…When the amount of bone graft is too large, patients are prone to dysphagia [8], and when the amount of bone graft is too small, long-term atlantoaxial complex fusion will be affected [6]. Many studies have shown that a porous metal structure can effectively promote the bone fusion rate, which has been verified in a variety of models [9][10][11]. By taking advantage of this characteristic of the porous metal structure, a new type of AATS was designed, threaded structures at both ends, and a porous metal structure in the middle.…”

Section: Introductionmentioning

confidence: 99%

Design a novel integrated screw for minimally invasive atlantoaxial anterior transarticular screw fixation: a finite element analysis

Zhang

et al. 2020

J Orthop Surg Res

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Purpose: To design a new type of screw for minimally invasive atlantoaxial anterior transarticular screw (AATS) fixation with a diameter that is significantly thicker than that of traditional screws, threaded structures at both ends, and a porous metal structure in the middle. The use of a porous metal structure can effectively promote bone fusion and compensate for the disadvantages of traditional AATSs in terms of insufficient fixation strength and difficulty of bone fusion. The biomechanical stability of this screw was verified through finite element analysis. This instrument may provide a new surgical option for the treatment of atlantoaxial disorders. Methods: According to the surgical procedure, the new type of AATS was placed in a three-dimensional atlantoaxial model to determine the setting of relevant parameters such as the diameter, length, and thread to porous metal ratio of the structure. According to the results of measurement, the feasibility and safety of the new AATS were verified, and a representative finite element model of the upper cervical vertebrae was chosen to establish, and the validity of the model was verified. Then, finite element-based biomechanical analysis was performed using three models, i.e., atlantoaxial posterior pedicle screw fixation, traditional atlantoaxial AATS fixation, and atlantoaxial AATS fixation with the new type of screw, and the biomechanical effectiveness of the novel AATS was verified.

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“…Clearly, this is a big task for all stakeholders involved in arthroplasty with the aim of achieving the best clinical outcome. The anatomic site also plays an important role in choosing an implant and a surface where osseointegration is part of the clinical paradigm [14].…”

Section: Introductionmentioning

confidence: 99%

Bone ongrowth and mechanical fixation of implants in cortical and cancellous bone

et al. 2020

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Background: What is the right surface for an implant to achieve biological fixation? Surface technologies can play important roles in encouraging interactions between the implant surface and the host bone to achieve osseointegration. Preclinical animal models provide important insight into in vivo performance related to bone ongrowth and implant fixation. Methods: A large animal model was used to compare the in vivo response of HA and plasma-sprayed titanium coatings in a well-reported adult ovine model to evaluate bone ongrowth in terms of mechanical properties in cortical sites, and histology and histomorphometry in cortical and cancellous sites at 4 and 12 weeks. Results: Titanium plasma-sprayed surfaces outperformed the HA-coated samples in push-out testing in cortical sites while both surfaces supported new bone ongrowth and remodeling in cortical and cancellous sites. Conclusions: While both HA and Ti plasma provided an osteoconductive surface for bone ongrowth, the Ti plasma provided a more robust bone-implant interface that ideally would be required for load transfer and implant stability in the longer term.

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Does implantation site influence bone ingrowth into 3D-printed porous implants?

Cited by 41 publications

References 51 publications

3D-printed titanium implant-coated polydopamine for repairing femoral condyle defects in rabbits

3D-printed titanium implant-coated polydopamine for repairing femoral condyle defects in rabbits

Design a novel integrated screw for minimally invasive atlantoaxial anterior transarticular screw fixation: a finite element analysis

Bone ongrowth and mechanical fixation of implants in cortical and cancellous bone

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