Does incentive-elicited nucleus accumbens activation differ by substance of abuse? An examination with adolescents

Karoly, Hollis C.; Bryan, Angela D.; Weiland, Barbara J.; Mayer, Andrew R.; Dodd, Andrew B.; Ewing, Sarah W. Feldstein

doi:10.1016/j.dcn.2015.05.005

Cited by 52 publications

(66 citation statements)

References 88 publications

(120 reference statements)

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“…While existing studies have shown increased NAcc activation to monetary reward anticipation among marijuana users 23,24 or no significant differences from controls 25–27 , we found decreased NAcc activation over time. Prior cross-sectional studies may not have been able to account for preexisting differences in NAcc activation that predisposed certain individuals toward engaging in reward seeking behavior, such as substance use.…”

Section: Discussioncontrasting

confidence: 99%

“…To allow comparison with prior cross-sectional studies 23–25,27 , we also investigated associations between Time 1 NAcc activation and prior marijuana use and age at first use using partial correlations, controlling for prior binge drinking and cigarette use.…”

Section: Methodsmentioning

confidence: 99%

“…Monetary reward anticipation during the MIDT reliably and robustly activates the VS, including the NAcc. Some studies report that marijuana users show increased activation of the VS to monetary reward anticipation compared to non-users 23,24 , whereas others have found no differences 25–27 . Cross-sectional studies, however, may be unable to disentangle differences in activation due to preexisting neural susceptibilities compared to altered neural function as a result of marijuana use.…”

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confidence: 99%

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Association of Marijuana Use With Blunted Nucleus Accumbens Response to Reward Anticipation

et al. 2016

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Importance Marijuana use may alter ventral striatal response to reward, which may heighten susceptibility to substance use disorder (SUD). Cross-sectional studies have reported either increased ventral striatal response to reward or no difference in marijuana users compared with controls. Longitudinal research is needed to resolve the inconsistencies and disentangle preexisting susceptibility from the effects of marijuana use on neural function involved in reward responding. Objective To determine whether marijuana use among young adults prospectively impacts nucleus accumbens (NAcc) activation during reward anticipation. Design Longitudinal study of self-report marijuana use and brain function using functional magnetic resonance imaging (fMRI) at three consecutive time points. Setting Data were obtained from young adult participants in the Michigan Longitudinal Study, an ongoing, prospective study of youth at high risk for SUD and a contrast sample of control families. Participants The sample consisted of 108 young adults (36% female; 78% family history of SUD) who underwent three fMRI scans at approximately age 20 (time 1), 22 (time 2), and 24 (time 3). Main Outcome and Measures We investigated the impact of marijuana use on neural response in the NAcc to reward anticipation during a monetary incentive delay task (MIDT) using a cross-lagged model. Covariates for analyses included sex, age at first scan, family history of SUD, prior marijuana use, and binge drinking (prior and concurrent). This model was also tested separately with the inclusion of cigarette smoking. Results Greater marijuana use was associated with later blunted activation in the NAcc during reward anticipation (time 1 to time 2: β=−0.26, P=0.04; time 2 to time 3: β=−0.25, P=0.01). When we tested the cross-lagged model with the inclusion of prior and concurrent cigarette use, the impact of marijuana use from time 2 to time 3 remained significant and the effect of cigarette use was non-significant. Conclusions and Relevance Our findings indicate that marijuana use is associated with decreased neural response in the NAcc during the anticipation of non-drug rewards. Over time, marijuana use may alter anticipatory reward processing in the NAcc, which may increase risk for continued drug use and later addiction.

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Section: Discussioncontrasting

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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Association of Marijuana Use With Blunted Nucleus Accumbens Response to Reward Anticipation

et al. 2016

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“…Data for adolescents were pooled from two existing neuroimaging studies among high-risk adolescents who were recruited to participate in a sexual health intervention [44–46]. Importantly, subsamples within the pooled dataset have been reported upon previously [8, 42], and were included here to maximize sample sizes and include a wide range of substance use.…”

Section: Methodsmentioning

confidence: 99%

Structural neuroimaging correlates of alcohol and cannabis use in adolescents and adults

et al. 2017

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Background and Aims Chronic alcohol use is associated with lower gray matter volume, and we recently reported that alcohol use showed negative associations with widespread gray matter (GM) volume even among young adults. The current study aimed to test the strength of association between (1) alcohol use and GM volume; (2) alcohol use and white matter (WM) integrity; (3) cannabis use and GM volume; and (4) cannabis use and WM integrity among adults and adolescents. Design and Setting General linear models within large pooled cross-sectional samples of adolescents and adults who had participated in studies collecting substance use and neuroimaging data in the southwestern United States. Participants The current analysis included adults ages 18–55 years (N=853) and adolescents ages 14–18 years (N=439) with a range of alcohol and cannabis use. Measurements The dependent variable was GM volume or WM integrity, with key predictors of alcohol use (AUDIT score) and cannabis use (past 30-day use). Findings Alcohol use showed large clusters of negative associations (ηp2=.028 to .145, p<.001) with GM volume among adults, and to a lesser extent (one cluster; ηp2=.070, p<.05) among adolescents. Large clusters showed significant associations (ηp2=.050 to .124, p<.001) of higher alcohol use with poorer WM integrity, whereas adolescents showed no significant associations between alcohol use and WM. No associations were observed between structural measures and past 30-day cannabis use in adults or adolescents. Conclusions Alcohol use severity is associated with widespread lower gray matter volume and white matter integrity in adults, and with lower gray matter volume in adolescents.

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“…Neuroanatomical regions of interest were selected based on prior delay discounting and reward processing literature suggesting involvement of nucleus accumbens and [39,40]; IFG, insula, putamen, and caudate [31,41]; and dorsal anterior cingulate cortex (dACC) and dlPFC [31,34,40]. Signal change value extraction was performed in MarsBaR version 0.43 for MATLAB [42], using bilateral spherical regions of interest (i.e., based upon the above literature and Harvard-Oxford atlases) centered at the following MNI coordinates.…”

Section: Regions Of Interestmentioning

confidence: 99%

Neural activation during delay discounting is associated with 6-month change in risky sexual behavior in adolescents

Gardiner

Karoly

Thayer

et al. 2018

Annals of Behavioral Medicine

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Background Identifying cognitive and neural mechanisms of decision making in adolescence can enhance understanding of, and interventions to reduce, risky health behaviors in adolescence. Delay discounting, or the propensity to discount the magnitude of temporally distal rewards, has been associated with diverse health risk behaviors, including risky sex. This cognitive process involves recruitment of reward and cognitive control brain regions, which develop on different trajectories in adolescence and are also implicated in real-world risky decision making. However, no extant research has examined how neural activation during delay discounting is associated with adolescents' risky sexual behavior. Purpose To determine whether a relationship exists between adolescents' risky sexual behavior and neural activation during delay discounting. Methods Adolescent participants completed a delay discounting paradigm during functional magnetic resonance imaging (fMRI) scanning, and they reported risky sexual behavior at baseline, 3-, 6-, 9-, and 12-month follow-up time points. Latent growth curve models were employed to determine relationships between brain activation during delay discounting and change in risky sexual behavior over time.Results Greater activation in brain regions associated with reward and cognitive control (caudate, putamen, nucleus accumbens, anterior cingulate, insula, orbitofrontal cortex, inferior frontal gyrus, dorsolateral prefrontal cortex) during delay discounting was associated with lower mean levels of risky sexual behavior but greater growth over the period from baseline to 6 months. Conclusions Neural activation during delay discounting is cross-sectionally and prospectively associated with risky sexual behavior in adolescence, highlighting a neural basis of risky decision-making as well as opportunities for early identification and intervention.

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Does incentive-elicited nucleus accumbens activation differ by substance of abuse? An examination with adolescents

Cited by 52 publications

References 88 publications

Association of Marijuana Use With Blunted Nucleus Accumbens Response to Reward Anticipation

Association of Marijuana Use With Blunted Nucleus Accumbens Response to Reward Anticipation

Structural neuroimaging correlates of alcohol and cannabis use in adolescents and adults

Neural activation during delay discounting is associated with 6-month change in risky sexual behavior in adolescents

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