Does joint alignment affect the T2 values of cartilage in patients with knee osteoarthritis?

Friedrich, Klaus; Shepard, Timothy F.; Chang, Gregory; Wang, Ligong; Babb, James S.; Schweitzer, Mark E.; Regatte, Ravinder R.

doi:10.1007/s00330-009-1689-7

Cited by 31 publications

(30 citation statements)

References 29 publications

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“…The patellar cartilage was shown to demonstrate more in vivo deformation than the femoral and tibial cartilages with weight-bearing loaded activities ( 30 ). Our results are also in keeping with those of Friedrich et al ( 32 ), who demonstrated that cartilage T2 values in the medial compartment Multiple previous studies of the prevalence of OA (23)(24)(25) evaluated the presence and severity of OA primarily with use of the radiographybased Kellgren and Lawrence grading system ( 26 ), which is heavily dependent on osteophytes for classifi cation of disease and suffers from its own morphologic abnormalities, particularly cartilage lesions, at 3-T MR imaging. We found a signifi cant longitudinal increase in tibiofemoral cartilage T2 values in asymptomatic individuals and demonstrated that increased progression of cartilage abnormalities correlated with a greater increase in T2.…”

Section: Discussionsupporting

confidence: 92%

Knee Cartilage T2 Characteristics and Evolution in Relation to Morphologic Abnormalities Detected at 3-T MR Imaging: A Longitudinal Study of the Normal Control Cohort from the Osteoarthritis Initiative

Pan¹,

Pialat²,

Joseph³

et al. 2011

Radiology

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Purpose:To determine the frequency of degenerative knee morphologic abnormalities in asymptomatic individuals by using 3-T magnetic resonance (MR) imaging and to investigate the characteristics and evolution of cartilage T2 values in relation to morphologic abnormalities with a longitudinal study. Materials and Methods:The study was approved by the institutional review board and was compliant with HIPAA. Ninety-fi ve asymptomatic subjects aged 45-78 years who were free of risk factors for osteoarthritis (OA) were selected from the Osteoarthritis Initiative normal control cohort and examined with radiography and 3-T MR imaging. Data obtained at both baseline and 2-year follow-up were analyzed. OA-related knee abnormalities were analyzed by using the wholeorgan MR imaging score (WORMS). Cartilage T2 maps were generated by using sagittal two-dimensional multiecho spin-echo images of the right knee. Statistical significance was determined with the Student t test, the paired t test, a mixed random effects model, one-way analysis of variance, and a multiple linear regression model. Results:Knee abnormalities were identifi ed with a high frequency (90% at baseline and 92 % at 2-year follow-up). The prevalence of hyaline cartilage lesions was particularly high (86% at baseline and 84% at follow-up). A signifi cant longitudinal increase in T2 was detected in the tibiofemoral cartilage but not the patellofemoral cartilage ( P = .0072). The longitudinal change in T2 was signifi cantly associated with worsening of the cartilage WORMS ( P = .038). Conclusion:Asymptomatic subjects have a high frequency of OA-related morphologic abnormalities. A signifi cant increase in tibiofemoral cartilage T2 was detected over the 2-year period. A greater increase in T2 was associated with increased progression of cartilage morphologic abnormalities.q RSNA, 2011

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Section: Discussionsupporting

confidence: 92%

Knee Cartilage T2 Characteristics and Evolution in Relation to Morphologic Abnormalities Detected at 3-T MR Imaging: A Longitudinal Study of the Normal Control Cohort from the Osteoarthritis Initiative

Pan¹,

Pialat²,

Joseph³

et al. 2011

Radiology

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“…loss of superficial cartilage with long relaxation times). Instead, this change may potentially be attributed to a shift towards more varus induced by narrowing of the medial joint space 38 .…”

Section: Discussionmentioning

confidence: 99%

Subregional laminar cartilage MR spin–spin relaxation times (T2) in osteoarthritic knees with and without medial femorotibial cartilage loss – data from the Osteoarthritis Initiative (OAI)

Wirth

Maschek

Beringer

et al. 2017

Osteoarthritis and Cartilage

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Objective To explore whether subregional laminar femorotibial cartilage spin-spin relaxation time (T2) is associated with subsequent radiographic progression and cartilage loss and/or whether one-year change in subregional laminar femorotibial cartilage T2 is associated with concurrent progression in knees with established radiographic OA (ROA). Methods In this case-control study, Osteoarthritis Initiative (OAI) knees with medial femorotibial progression were selected based on one-year loss in both quantitative cartilage thickness (MRI) and radiographic JSW. Non-progressor knees were matched by sex, BMI, baseline Kellgren-Lawrence-grade (2/3), and pain. Baseline and 1-year follow-up superficial and deep cartilage T2 was analyzed in 16 femorotibial subregions using multi-echo spin-echo MRI. Results 37 knees showed medial femorotibial progression whereas 37 matched controls had no medial or lateral compartment progression. No statistically significant baseline differences between progressor and non-progressor knees in medial femorotibial cartilage T2 were observed in the superficial (48.9±3.0ms; 95%CI:[47.9,49.9] vs. 47.8±3.6ms; 95%CI:[46.6,49.0], p=0.07) or deep cartilage layer (40.8±3.6ms; 95%CI:[39.5,42.0] vs. 40.1±4.7ms; 95%CI:[38.5,41.6], p=0.29). Concurrent T2 change was more pronounced in the deep than the superficial cartilage layer. In the medial femorotibial compartment, longitudinal change was greater in the deep layer of progressor than non-progressor knees (1.8±4.5ms; 95%CI:[0.3,3.3] vs. −0.2±1.9ms; 95%CI:[−0.8,0.5], p=0.02), whereas no difference was observed in the superficial layer. Conclusion Medial compartment cartilage T2 did not appear to be a strong prognostic factor for subsequent structural progression in the same compartment of knees with established ROA, when appropriately controlling for covariates. Yet, deep layer T2 change in the medial compartment occurred concurrent with medial femorotibial progression.

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“…4 In cohorts of less than 30 individuals, people with medial knee OA who had varus alignment were found to have higher cartilage T1rho and T2 than those with valgus alignment. 20,55 Most of these studies either were in healthy cohorts or had a small sample size. Longitudinal studies in larger samples, like the OAI cohort, are needed to understand the effect of these OA risk factors on cartilage degeneration over time.…”

Section: Discussionmentioning

confidence: 99%

Physical Activity and Spatial Differences in Medial Knee T1rho and T2 Relaxation Times in Knee Osteoarthritis

Kumar

Souza

Singh

et al. 2014

J Orthop Sports Phys Ther

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STUDY DESIGN Cross-sectional. OBJECTIVES To investigate the association between knee loading–related osteoarthritis (OA) risk factors (obesity, malalignment, and physical activity) and medial knee laminar (superficial and deep) T1rho and T2 relaxation times. BACKGROUND The interaction of various modifiable loading-related knee risk factors and cartilage health in knee OA is currently not well known. METHODS Participants with and without knee OA (n = 151) underwent magnetic resonance imaging at 3 T for superficial and deep cartilage T1rho and T2 magnetic resonance relaxation times in the medial femur (MF) and medial tibia (MT). Other variables included radiographic Kellgren-Lawrence (KL) grade, alignment, pain and symptoms using the Knee injury and Osteoarthritis Outcome Score, and physical activity using the International Physical Activity Questionnaire (IPAQ). Individuals with a KL grade of 4 were excluded. Group differences were calculated using 1-way analysis of variance, adjusting for age and body mass index. Linear regression models were created with age, sex, body mass index, alignment, KL grade, and the IPAQ scores to predict the laminar T1rho and T2 times. RESULTS Total IPAQ scores were the only significant predictors among the loading-related variables for superficial MF T1rho (P = .005), deep MT T1rho (P = .026), and superficial MF T2 (P = .049). Additionally, the KL grade predicted the superficial MF T1rho (P = .023) and deep MT T1rho (P = .022). CONCLUSION Higher physical activity levels and worse radiographic severity of knee OA, but not obesity or alignment, were associated with worse cartilage composition.

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Does joint alignment affect the T2 values of cartilage in patients with knee osteoarthritis?

Cited by 31 publications

References 29 publications

Knee Cartilage T2 Characteristics and Evolution in Relation to Morphologic Abnormalities Detected at 3-T MR Imaging: A Longitudinal Study of the Normal Control Cohort from the Osteoarthritis Initiative

Knee Cartilage T2 Characteristics and Evolution in Relation to Morphologic Abnormalities Detected at 3-T MR Imaging: A Longitudinal Study of the Normal Control Cohort from the Osteoarthritis Initiative

Subregional laminar cartilage MR spin–spin relaxation times (T2) in osteoarthritic knees with and without medial femorotibial cartilage loss – data from the Osteoarthritis Initiative (OAI)

Physical Activity and Spatial Differences in Medial Knee T1rho and T2 Relaxation Times in Knee Osteoarthritis

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