Does MAOA increase susceptibility to prenatal stress in young children?

Massey, Suena H.; Hatcher, Amalia E.; Clark, Caron A. C.; Burns, James; Pine, Daniel S.; Skol, Andrew D.; Mroczek, Daniel K.; Espy, Kimberly Andrews; Goldman, David; Cook, Edwin H.; Wakschlag, Lauren S.

doi:10.1016/j.ntt.2017.01.005

Cited by 9 publications

(11 citation statements)

References 81 publications

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“…The meta-analysis by Byrd and Manuck reported weak findings of an interaction between MAOA -HH and child maltreatment in predicting female antisocial outcomes, although the finding did not survive adjustment after removal of either of two study cohorts, and the interaction with general life adversities was not significant (Byrd and Manuck 2014 ). Sex differences are supported by some findings of three-way interactions of MAOA , environmental adversity and sex in relation to antisocial outcomes (Frazzetto et al 2007 ; Massey et al 2017 ; Holz et al 2016 ).…”

Section: Results Of Systematic Reviews Of Maoa G×ementioning

confidence: 88%

“…Massey and co-workers (Massey et al 2017 ) investigated prenatal and concurrent stress exposure in a longitudinal cohort study of children from infancy to 5 years of age. They reported a three-way interaction of prenatal stress, MAOA and sex in relation to disruptive behaviour at age 5 years.…”

Section: Results Of Systematic Reviews Of Maoa G×ementioning

confidence: 99%

“…No significant interactions were found in girls. The authors speculated that testosterone levels associated with the pubertal transition in boys may alter the function or influence of MAOA on behaviour (Massey et al 2017 ). However, a previous study on boys younger than 7 years identified the MAOA -L as a risk/plasticity allele, similar to findings in adolescents and adults (Kim-Cohen et al 2006 ).…”

Section: Results Of Systematic Reviews Of Maoa G×ementioning

confidence: 99%

“…For example, several publications include illustrations indicating possible differential susceptibility effects of MAOA -L in men (Caspi et al 2002 ; Kim-Cohen et al 2006 ; Nilsson et al 2006 ; Widom and Brzustowicz 2006 ; Frazzetto et al 2007 ; Enoch et al 2010 ; Wakschlag et al 2010 ; Cicchetti et al 2012 ; Hill et al 2013 ; Armstrong et al 2014 ; Gorodetsky et al 2014 ; Holz et al 2016 ) and of MAOA -HH in women (Holz et al 2016 ; Prom-Wormley et al 2009 ; Wakschlag et al 2010 ). However, inconsistent patterns of possible sex differences in assumed allelic plasticity are also apparent (Enoch et al 2010 ; Hill et al 2013 ; Massey et al 2017 ).…”

Section: Results Of Systematic Reviews Of Maoa G×ementioning

confidence: 99%

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Gene–environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions

et al. 2018

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Since the pioneering finding of Caspi and co-workers in 2002 that exposure to childhood maltreatment predicted later antisocial behaviour (ASB) in male carriers of the low-activity MAOA-uVNTR allele, frequent replication studies have been published. Two meta-analyses, one in 2006 and the other in 2014, confirmed the original findings by Caspi and co-workers. In the present paper, we review the literature, note some methodological aspects of candidate gene–environment interaction (cG×E) studies and suggest some future directions. Our conclusions are as follows. (1) The direction of the effect in a cG×E model may differ according to the positive and negative environmental background of the population. (2) There is a predictor-intersection problem such that when measuring one type of maltreatment in a person, other kinds of maltreatment often co-occur. Other forms of abuse are implicitly considered in statistical models; therefore, it is difficult to draw conclusions about the effects of timing and the severity of different forms of stressful life events in relation to ASB. (3) There is also an outcome-intersection problem because of the major intersection of ASB and other forms of mental health problems. It is likely that the G×E with MAOA is related to a common unmeasured factor. (4) For the G×E model, in which the effect of the gene on the outcome variable is dependent on other predictor variables, theoretically, hypothesis-driven statistical modelling is needed.

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Section: Results Of Systematic Reviews Of Maoa G×ementioning

confidence: 88%

Section: Results Of Systematic Reviews Of Maoa G×ementioning

confidence: 99%

Section: Results Of Systematic Reviews Of Maoa G×ementioning

confidence: 99%

Section: Results Of Systematic Reviews Of Maoa G×ementioning

confidence: 99%

See 2 more Smart Citations

Gene–environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions

et al. 2018

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“…clinical patterns such as attention-deficit/hyperactivity disorder and disruptive behavior [5,9,14,37]. There is a critical need to detect such exposures to stress in real-world situations in order to deliver timely stress-reduction interventions to improve maternal well-being and offspring neurodevelopment.…”

mentioning

confidence: 99%

micro-Stress EMA

King

Moskowitz

Egilmez

et al. 2019

Proc. ACM Interact. Mob. Wearable Ubiquitous Technol.

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High levels of stress during pregnancy increase the chances of having a premature or lowbirthweight baby. Perceived self-reported stress does not often capture or align with the physiological and behavioral response. But what if there was a self-report measure that could better capture the physiological response? Current perceived stress self-report assessments require users to answer multi-item scales at different time points of the day. Reducing it to one question, using microinteraction-based ecological momentary assessment (micro-EMA, collecting a single in situ self-report to assess behaviors) allows us to identify smaller or more subtle changes in physiology. It also allows for more frequent responses to capture perceived stress while at the same time reducing burden on the participant. We propose a framework for selecting the optimal micro-EMA that combines unbiased feature selection and unsupervised Agglomerative clustering. We test our framework in 18 women performing 16 activities in-lab wearing a Biostamp, a NeuLog, and a Polar chest strap. We validated our results in 17 pregnant women in real-world settings. Our framework shows that the question "How worried were you?" results in the highest accuracy when using a physiological model. Our results provide further in-depth exposure to the challenges of evaluating stress models in real-world situations. 1 INTRODUCTION While immediate short-term mental and physical stress can be beneficial to health, prolonged elevated stress levels negatively affect the body's respiratory, cardiovascular, digestive, muscular, reproductive, nervous, and immune systems [18, 50, 54]. Prolonged stress can also contribute to poor health behaviors such as overeating [45], smoking [34], alcohol [42] and substance abuse [46]. These behaviors, in turn, are associated with conditions such as hypertension, heart disease, and depression [8]. Indeed, stress exposure in utero has been linked to deleterious outcomes for the child including impaired motor development, lower mental development, heightened behavioral disinhibition, and associated

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The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men

Kolla

Bortolato

2020

Progress in Neurobiology

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Does MAOA increase susceptibility to prenatal stress in young children?

Cited by 9 publications

References 81 publications

Gene–environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions

Gene–environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions

micro-Stress EMA

The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men

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