“…The life course approach is the study of long-term effects on chronic disease risk of physical and social exposures during gestation, childhood, adolescence, young adulthood, and later adult life (14). In disadvantaged populations and underserved communities, oral disease risk is elevated throughout the life course owing to, e.g., socioeconomic status, discrimination, and lack of eligibility and/or high out-of-pocket costs for public and private insurance coverage (9,12,19,97,99,116). In particular, exposures that are patterned by social factors include poor nutrition, lack of preventive primary and oral health care (including vaccination against HPV), inferior quality of restorative oral health care (31,34), violence and injury leading to face trauma, and excessive alcohol and tobacco use, all of which may affect teeth and their supporting structures, leading to dental caries (beginning in early childhood), oropharyngeal cancer (currently an epidemic among younger men), periodontal disease (highly prevalent with increasing age), oral cancers (especially in older men), and eventually root caries and tooth loss (particularly in older adults).…”