Does Metabolic Syndrome Affect the Incidence and Prognosis of Sudden Sensorineural Hearing Loss?

Park, Joong Su; Kim, Seung Ho; Kim, Ikhee; Kim, Hantai; Kim, Ji Hyun; Lee, Jong Bin

doi:10.3390/life12070930

Cited by 9 publications

(9 citation statements)

References 24 publications

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“…Research Question 1: Risk Factors of iSSNHL Of the total of 6,641 articles, full text was assessed for 62. Repetition of the search strategy just before completion of the article resulted in another eligible study [Park et al, 2022]. A total of 33 articles met the inclusion criteria; 21 of these investigated total cholesterol values, 18 investigated HDL-cholesterol, 19 investigated low-density lipoprotein (LDL)-cholesterol, 13 investigated hypertension, 12 investigated DM, 14 investigated smoking, 5 investigated history of MI, and 9 investigated BMI.…”

Section: Resultsmentioning

confidence: 99%

“…Eleven articles presented unadjusted results [Suckfüll et al, 2002;Quaranta et al, 2008;Ballesteros et al, 2009;Oiticica and Bittar, 2010;Oreskovic et al, 2011;Mohammed, 2014;Fasano et al, 2017;Umesawa et al, 2017;Rinaldi et al, 2020;Genç Elden et al, 2022;Park et al, 2022]. Two studies adjusted for several CVRFs together, without a separate analysis per risk factor [Passamonti et al, 2015;Chien et al, 2016].…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

“…HDL-cholesterol values were assessed in 18 articles [Suckfüll et al, 2002;Rudack et al, 2006;Quaranta et al, 2008;Ballesteros et al, 2009;Oreskovic et al, 2011;Ciccone et al, 2012;Weng et al, 2013;Mohammed, 2014;Lee et al, 2015;Chien et al, 2016;Rajati et al, 2016;Fasano et al, 2017;Kaneva et al, 2019;Jalali and Azgomi, 2020;Rinaldi et al, 2020;Li et al, 2021;Genç Elden et al, 2022;Park et al, 2022]. However, one article did not describe the absolute value of HDL in the control cohort and could therefore not be included in the meta-analysis [Ballesteros et al, 2009].…”

Section: Hdl-cholesterolmentioning

confidence: 99%

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Cardiovascular Risk Factors, Cerebral Small Vessel Disease, and Subsequent Risk of Stroke in Patients with Idiopathic Sudden Sensorineural Hearing Loss: Systematic Review and Meta-Analyses of the Current Literature

Oussoren,

Schermer,

van Leeuwen

et al. 2023

Audiol Neurotol

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Vascular involvement in the pathophysiology of idiopathic sudden sensorineural hearing loss (iSSNHL) has been previously proposed. The objective of this study was to perform a systematic review of the current literature and conduct meta-analyses to evaluate associations between cardiovascular risk factors, cerebral small vessel disease, and subsequent stroke after presentation with iSSNHL. Three systematic literature reviews and meta-analyses were conducted using PubMed, Embase, and CINAHL. All studies investigating associations between iSSNHL and the cardiovascular risk factors: body mass index (BMI), diabetes mellitus, hyperlipidemia, hypertension, medical history of myocardial infarction (MI), smoking, the degree of white matter hyperintensities, and incidence of stroke were included. Adhering to the PRISMA guidelines, two independent reviewers reviewed the articles and assessed risk of bias. The cardiovascular risk factors of abnormal BMI, diabetes, hypertension, total cholesterol, low-density lipoprotein cholesterol, and a medical history of MI were significantly associated with iSSNHL. The adjusted hazard ratio of a higher degree of white matter hyperintensities was 0.70 (95% CI 0.44, 1.12). Patients with iSSNHL showed a higher risk of stroke compared to controls, with hazard ratios ranging from 1.22 up to 4.08. Several cardiovascular risk factors are more frequently present in patients with iSSNHL than in the general population. The degree of white matter hyperintensities does not appear to be increased in patients with iSSNHL, while the risk of stroke following ISSNHL is increased. Prospective studies with larger study populations are needed to confirm the associations between generalized cardiovascular disease and iSSNHL and to assess whether these patients benefit from cardiovascular risk management to prevent future cardiovascular and cerebrovascular disease.

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Section: Resultsmentioning

confidence: 99%

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

Section: Hdl-cholesterolmentioning

confidence: 99%

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Cardiovascular Risk Factors, Cerebral Small Vessel Disease, and Subsequent Risk of Stroke in Patients with Idiopathic Sudden Sensorineural Hearing Loss: Systematic Review and Meta-Analyses of the Current Literature

Oussoren,

Schermer,

van Leeuwen

et al. 2023

Audiol Neurotol

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“…There is growing attention paid to the relationship between diabetes and inner ear structures. [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ] In particular, there is a wealth of evidence suggesting that hearing loss (HL) may be a disabling complication of diabetes mellitus (DM) [ 26 , 27 ]. The consequences of DM affecting the ear can include the ability to understand speech, the risk of falling, and the onset of tinnitus, with concerns ranging from a lowered quality of life to an increase in mortality.…”

Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus and Hearing Loss: A Complex Relationship

et al. 2023

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Background and Objectives: Discussion is open about the relationship between diabetes (DM) and hearing loss (HL). There is a lot of evidence in the literature suggesting a causal link between these conditions, beyond being considered simple comorbidities. The difficulty in identifying populations free from confounding factors makes it difficult to reach definitive conclusions on the pathophysiological mechanisms at play. Nonetheless, there is numerous evidence that demonstrates how the population affected by DM is more affected by sensorineural HL (SNHL) and exhibit a higher prevalence of idiopathic sudden sensorineural HL (ISSNHL). Materials and Methods: Articles reporting potentially relevant information were reviewed, and the most significant results are discussed in this article. Starting from the possible mechanisms relating to auditory impairment in the diabetic condition, this article summarizes the studies on auditory evaluation in subjects with DM1 and DM2 and addresses the relationship between DM and ISSNHL. Results: DM is considered a risk factor for SNHL, although some studies have reported no relationship when the associations were adjusted for age, gender, and hypertension. Macro and microvascular insults that cause decreased blood flow, oxygen exchange, and ion transport are major complications of hypertension and DM and can have a direct effect on the sensory and support cells of the cochlea. Conclusions: Given the difficulty of carrying out studies on populations without confounding factors, new laboratory studies are strongly required to clarify which specific physiopathological mechanisms underlie the diabetic damage caused to the hearing organs and how pharmacological management may contribute to counteracting the pathophysiological effects of the diabetic condition on the auditory system.

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“…As a medical emergence, detailed examination to determine possible causes and early treatment onset is extremely important to improve hearing prognosis in SSNHL patients ( Jiang et al, 2021 ; Huo et al, 2022 ). Although numerous studies were performed to determine the diagnostic and prognostic biomarkers in SSNHL, no reliable indicator was available in practice ( Huo et al, 2022 ; Park et al, 2022 ). Recently, an increasing number of evidence showed that metabolic diseases were independent risk factors for the occurrence of SSNHL, and pathoglycemia and dyslipidemia significantly affected hearing recovery ( Doo et al, 2020 ; Chen et al, 2022a ; Simões et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients

Wang

Gao

Jiang

2022

Front. Mol. Biosci.

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Sudden sensorineural hearing loss (SSNHL) is an otologic emergency, and metabolic disturbance is involved in its pathogenesis. This study recruited 20 SSNHL patients and 20 healthy controls (HCs) and collected their serum samples. Serum metabolites were detected by liquid chromatography-mass spectrometry, and metabolic profiles were analyzed. All patients were followed up for 3 months and categorized into recovery and non-recovery groups. The distinctive metabolites were assessed between two groups, and their predictive values for hearing recovery were evaluated. Analysis results revealed that SSNHL patients exhibited significantly characteristic metabolite signatures compared to HCs. The top 10 differential metabolites were further analyzed, and most of them showed potential diagnostic values based on receiver operator characteristic (ROC) curves. Finally, 14 SSNHL patients were divided into the recovery group, and six patients were included in the non-recovery group. Twelve distinctive metabolites were observed between the two groups, and ROC curves demonstrated that N4-acetylcytidine, p-phenylenediamine, sphingosine, glycero-3-phosphocholine, and nonadecanoic acid presented good predictabilities in the hearing recovery. Multivariate analysis results demonstrated that serum N4-Acetylcytidine, sphingosine and nonadecanoic acid levels were associated with hearing recovery in SSNHL patients. Our results identified that SSNHL patients exhibited distinctive serum metabolomics signatures, and several serum biomarkers were proved to be potential in predicting hearing recovery. The discriminative metabolites might contribute to illustrating the mechanisms of SSNHL and provide possible clues for its treatments.

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Does Metabolic Syndrome Affect the Incidence and Prognosis of Sudden Sensorineural Hearing Loss?

Cited by 9 publications

References 24 publications

Cardiovascular Risk Factors, Cerebral Small Vessel Disease, and Subsequent Risk of Stroke in Patients with Idiopathic Sudden Sensorineural Hearing Loss: Systematic Review and Meta-Analyses of the Current Literature

Cardiovascular Risk Factors, Cerebral Small Vessel Disease, and Subsequent Risk of Stroke in Patients with Idiopathic Sudden Sensorineural Hearing Loss: Systematic Review and Meta-Analyses of the Current Literature

Diabetes Mellitus and Hearing Loss: A Complex Relationship

Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients

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