Does molecular scarring in psoriasis exist? A review of the literature

Kasprowicz-Furmańczyk, Marta; Borzęcki, Adam; Owczarczyk‐Saczonek, Agnieszka

doi:10.5114/ada.2023.129322

Cited by 3 publications

(2 citation statements)

References 52 publications

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“…Immune cells release pro-inflammatory cytokines such as TNF-α, IFN-γ and IL-1β, which, in turn, facilitate the activation of myeloid dendritic cells. These cells release IL-12 and IL-23, which are key cytokines for the differentiation of naive T cells into Th1, Th22 and Th17 cells [10,11]. In patients with psoriasis, increased activity of Th17 and Th22 cells has been confirmed compared to the healthy group.…”

Section: Discussionmentioning

confidence: 96%

“…Inflammatory skin conditions are accompanied by hyperproliferative reactions in the epidermis, caused by hyperactivation and production of immature keratinocytes. Psoriatic skin is characterized by a thickened epidermal layer, along with inflammatory infiltrates in the dermis primarily composed of dendritic cells, neutrophils, T lymphocytes and macrophages [7,10].…”

Section: Discussionmentioning

confidence: 99%

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The Unknown Role of Periostin in Psoriatic Epidermal Hyperplasia

Wojciechowska,

Ścibior,

Betyna-Białek

et al. 2023

IJMS

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Psoriasis is an inflammatory skin disease that affects 1–2% of the general population. The pathomechanism is based on type 1 immunological reactions. Hyperplasia of the epidermis in psoriasis is a result of disrupted epidermal architecture due to increased synthesis and expression of extracellular matrix proteins. In our study, we analyzed the involvement of periostin (POSTN) in the pathogenesis of psoriasis, as one of the extracellular matrix proteins belonging to the fasciclin family. The study group consisted of 70 patients with psoriasis, while the control group comprised 30 healthy individuals. The serum concentrations of POSTN, Il-6, Il-17, Il-22, TNF-α and IFN-γ were measured in all participants. The severity of psoriasis was determined using the PASI (Psoriasis Area and Severity Index) score. The presence of POSTN in biopsy samples of 50 patients was assessed using the direct immunofluorescence method. The results were subjected to statistical analysis. The serum concentrations of POSTN, Il-6, Il-17, Il-22, TNF-α and IFN-γ in the study group are significantly higher than in the control group. Positive correlation has been demonstrated between the PASI score and the investigated cytokines, but not with POSTN. There was no statistically significant correlation between the POSTN level and the cytokines levels. POSTN deposits were localized in the epidermis in 66% of patients with psoriasis. The role of POSTN in the pathogenesis of psoriasis remains unclear. The mechanisms inducing the synthesis and expression of POSTN in psoriatic skin are not yet fully understood. Further research is needed to enhance our understanding of the mechanism underlying epidermal hyperplasia in psoriasis.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

The Unknown Role of Periostin in Psoriatic Epidermal Hyperplasia

Wojciechowska,

Ścibior,

Betyna-Białek

et al. 2023

IJMS

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Clinical implication of tissue-resident memory T cells in psoriasis

Kim,

Baek

2024

JKSP

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The Expression of Cytokines and Chemokines Potentially Distinguishes Mild and Severe Psoriatic Non-Lesional and Resolved Skin from Healthy Skin and Indicates Different Stages of Inflammation

Bozó,

Flink,

Ambrus

et al. 2024

IJMS

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In the psoriatic non-lesional (PS-NL) skin, the tissue environment potentially influences the development and recurrence of lesions. Therefore, we aimed to investigate mechanisms involved in regulating tissue organization in PS-NL skin. Cytokine, chemokine, protease, and protease inhibitor levels were compared between PS-NL skin of patients with mild and severe symptoms and healthy skin. By comparing mild and severe PS-NL vs. healthy skin, differentially expressed cytokines and chemokines suggested alterations in hemostasis-related processes, while protease inhibitors showed no psoriasis severity-related changes. Comparing severe and mild PS-NL skin revealed disease severity-related changes in the expression of proteases, cytokines, and chemokines primarily involving methyl-CpG binding protein 2 (MECP2) and extracellular matrix organization-related mechanisms. Cytokine and chemokine expression in clinically resolved versus healthy skin showed slight interleukin activity, differing from patterns in mild and severe PS-NL skin. Immunofluorescence analysis revealed the severity-dependent nuclear expression pattern of MECP2 and decreased expression of 5-methylcytosine and 5-hydroxymethylcytosine in the PS-NL vs. healthy skin, and in resolved vs. healthy skin. Our results suggest distinct cytokine–chemokine signaling between the resolved and PS-NL skin of untreated patients with varying severities. These results highlight an altered inflammatory response, epigenetic regulation, and tissue organization in different types of PS-NL skin with possibly distinct, severity-dependent para-inflammatory states.

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Does molecular scarring in psoriasis exist? A review of the literature

Cited by 3 publications

References 52 publications

The Unknown Role of Periostin in Psoriatic Epidermal Hyperplasia

The Unknown Role of Periostin in Psoriatic Epidermal Hyperplasia

Clinical implication of tissue-resident memory T cells in psoriasis

The Expression of Cytokines and Chemokines Potentially Distinguishes Mild and Severe Psoriatic Non-Lesional and Resolved Skin from Healthy Skin and Indicates Different Stages of Inflammation

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