Does Motor Tract Integrity at 1 Month Predict Gait and Balance Outcomes at 6 Months in Stroke Patients?

Jun, Sun-Young; Hong, Bo Young; Kim, YoungKook; Lim, Seong Hoon

doi:10.3390/brainsci11070867

Cited by 8 publications

(12 citation statements)

References 28 publications

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“…In another view of function, after the stroke, the integrity of CST may be a predictive value for gait and the activities of daily living, as suggested by several reports [ 7 , 8 ]. In contrast to these results, our recent research showed that the integrity of CST might not be a predictive value for gait or balance [ 9 ]. Taken together, the CST may be a predictive value for several functions and be related to motor outcomes in patients with stroke.…”

Section: Introductionmentioning

confidence: 76%

“…To accurately measure hand function it is necessary to conduct a test that can measure dexterity, as in this study, rather than simply including power [ 37 ]. Although it is not a hand function, functional indicators such as the Berg Balance Scale (BBS) and the Functional Ambulation Categories (FAC) measured six months after a stroke were not related to acute phase FA values in the CST [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

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Preservation of Cerebellar Afferent Pathway May Be Related to Good Hand Function in Patients with Stroke

Shin

Park

Rim

et al. 2022

Life

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Many chronic stroke patients suffer from worsened hand function, and functional recovery of the hand does not occur well after six months of stroke. Therefore, predicting final hand function after stroke through acute phase imaging would be an important issue in counseling with the patients or their family. Thus, we investigated the remaining white matter integrity in the corticospinal tract (CST) and cortico-ponto-cerebellar tract (CPCT) at the acute stage of stroke and chronic hand function after stroke, and present the cut-off value of fiber number (FN) and fractional anisotropy (FA) of CST and CPCT at the acute stage for predicting final hand function after the recovery period. This retrospective case-control study included 18 stroke patients who were classified into two groups: poor hand function with stroke (n = 11) and good hand function with stroke (n = 7). DTI was done within two months ± 15 days after onset, and the Jebson’s Hand Function test was conducted 6–12 months after onset. The investigation of white matter was focused on the values of FN and FA for CST and CPCT, which were measured separately. The normalized (affected/non-affected) FA and FN values in the CPCT in the good hand function group were higher than those in the poor hand function group. The normalized FN and FA values in the CST were not significantly different between the poor hand function group and the good hand function group. The normalized cut-off value that distinguished the good hand function group from the poor hand function group was 0.8889 for FA in the CPCT. The integrity of the CPCT in the acute stage was associated with hand function in the chronic stage after a stroke. Ultimately, the integrity of the CPCT in the early stage after onset can be used to predict chronic hand function. Based on these results, cerebellar afferent fiber measurements may be a useful addition to predict hand function and plan specific rehabilitation strategies in stroke patients.

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Section: Introductionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Preservation of Cerebellar Afferent Pathway May Be Related to Good Hand Function in Patients with Stroke

Shin

Park

Rim

et al. 2022

Life

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“…They showed that the first cortical origin area of the CRP was the PMC, and the CRP was located close anteromedially to the CST in subcortical white matter. They also reported many studies on the role and recovery of CRP in walking ability in relation to posture and locomotion, the major roles of RST [17][18][19][20][32][33][34]. Although the DTI studies of CRP related to walking ability or balance after stroke and the reports on the role of CRP in the pathophysiology of PSS have increased, there were no studies on DTI of CRP in PSS.…”

Section: Discussionmentioning

confidence: 99%

“…However, there have been few DTI studies of CRP after stroke. The DTI studies on CRP after stroke only referred to the relationship between CRP and gait function [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study

Kim

Min

et al. 2021

JPM

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One of the pathophysiologies of post-stroke spasticity (PSS) is the imbalance of the reticulospinal tract (RST) caused by injury to the corticoreticular pathway (CRP) after stroke. We investigated the relationship between injuries of the CRP and PSS using MR diffusion tensor imaging (DTI). The subjects were divided into spasticity and control groups. We measured the ipsilesional fractional anisotropy (iFA) and contralesional fractional anisotropy (cFA) values on the reticular formation (RF) of the CRP were on the DTI images. We carried out a retrospective analysis of 70 patients with ischemic stroke. The cFA values of CRP in the spasticity group were lower than those in the control group (p = 0.04). In the sub-ROI analysis of CRP, the iFA values of pontine RF were lower than the cFA values in both groups (p < 0.05). The cFA values of medullary RF in the spasticity group were lower than the iFA values within groups, and also lower than the cFA values in the control group (p < 0.05). This results showed the CRP injury and that imbalance of RST caused by CRP injury was associated with PSS. DTI analysis of CRP could provide imaging evidence for the pathophysiology of PSS.

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“…Diffusion sensitizing gradients were applied in 64 noncollinear directions with a b-value of 1000 ms/mm 2 [ 14 ]. The b0 images were scanned before acquiring the diffusion-weighted images, with 65 volumes total [ 15 , 16 , 17 ]. Raw diffusion-weighted data were corrected for geometric distortion secondary to eddy currents using a registration technique based on a geometric model of distortion, as described by Lehéricy et al [ 18 , 19 ].…”

Section: Methodsmentioning

confidence: 99%

Changes in the Brain in Temporal Lobe Epilepsy with Unilateral Hippocampal Sclerosis: An Initial Case Series

Lim

Hong

et al. 2022

Healthcare

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Temporal lobe epilepsy (TLE) is a network disorder of the brain. Network disorders predominately involve dysregulation of hippocampal function caused by neuronal hyperexcitability. However, the relationship between the macro- and microscopic changes in specific brain regions is uncertain. In this study, the pattern of brain atrophy in patients with TLE and hippocampal sclerosis (HS) was investigated using volumetry, and microscopic changes in specific lesions were observed to examine the anatomical correspondence with specific target lesions using diffusion tensor imaging (DTI) with statistical parametric mapping (SPM). This retrospective cross-sectional study enrolled 17 patients with TLE and HS. We manually measured the volumes of the hippocampus (HC), amygdala (AMG), entorhinal cortex, fornix, and thalamus (TH) bilaterally. The mean diffusivity and fractional anisotropy of each patient were then quantified and analyzed by a voxel-based statistical correlation method using SPM8. In right TLE with HS, there was no evidence of any abnormal diffusion properties associated with the volume reduction in specific brain regions. In left TLE with HS, there were significant changes in the volumes of the AMG, HC, and TH. Despite the small sample size, these differences in conditions were considered meaningful. Chronic left TLE with HS might cause structural changes in the AMG, HC, and TH, unlike right TLE with HS.

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Does Motor Tract Integrity at 1 Month Predict Gait and Balance Outcomes at 6 Months in Stroke Patients?

Cited by 8 publications

References 28 publications

Preservation of Cerebellar Afferent Pathway May Be Related to Good Hand Function in Patients with Stroke

Preservation of Cerebellar Afferent Pathway May Be Related to Good Hand Function in Patients with Stroke

Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study

Changes in the Brain in Temporal Lobe Epilepsy with Unilateral Hippocampal Sclerosis: An Initial Case Series

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