Does MRS Lactate Peak Correlate with Lactate in the CSF and Blood?

Shibao, Simone; Otaduy, Maria C. G.; Kok, Fernando; Leite, Cláudia C.

doi:10.1055/s-0035-1564663

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…However, the study failed to demonstrate a direct correlation between CSF lactate and respective blood lactate concentrations outlined in Figure 1. This was also observed in a recent study in human medicine, 25 where elevated CNS lactate concentrations were not correlated with the blood lactate concentrations. A possible explanation is the complex anatomy of the blood‐CSF barrier, and the selective transport of certain molecules across that barrier.…”

Section: Discussionsupporting

confidence: 76%

Association between cerebrospinal fluid lactate concentration and central nervous system disease in dogs

Fitz

Reese²

2020

Veterinary Clinical Pathol

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BackgroundCerebrospinal fluid (CSF) analysis is a sensitive tool for evaluating patients with neurologic diseases but is rarely specific. Biomarkers can be measured from any bodily fluid and can be useful indicators for the presence, severity, and prognosis of diseases.ObjectivesThis study was designed to evaluate if CSF lactate can be used as a biomarker in dogs with central nervous system disease.MethodsPeripheral venous blood and CSF were collected from 49 dogs with various intracranial diseases to evaluate correlations between blood and CSF lactate levels. Total nucleated cell count (TNCC) and CSF protein concentrations were also evaluated. All samples obtained were divided into normal (NG) and abnormal (AG) dogs based on a TNCC of ≤5 and >5 cells/μL and a protein concentration of ≤25 and >25 mg/dL, respectively. The AG dogs were further subdivided into those having <100 TNCCs/µL (AGL) and those having >100 TNCCs/µL (AGH). They were also subdivided into groups based on seizure activity (AGS), and inflammatory (AGI), or neoplastic diseases (AGN), and the respective lactate concentrations were then compared.ResultsLactate concentrations were significantly increased in CSF and venous blood samples in the AG compared with the NG dogs, but no differences were found among the individual disease processes. In all dogs, CSF lactate concentrations were higher than venous blood lactate levels; however, no direct correlation between CSF and blood lactate concentrations was identified.ConclusionsCerebrospinal fluid lactate can be used as a biomarker in clinical settings as it can be measured via a commercially available lactometer immediately after collection without the need for special instrumentation or laboratory personnel.

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Section: Discussionsupporting

confidence: 76%

Association between cerebrospinal fluid lactate concentration and central nervous system disease in dogs

Fitz

Reese²

2020

Veterinary Clinical Pathol

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“…Our study adds that if the phenotype of a mitochondrial disease is less recognizable, MRS brain tissue lactate and L/Cr ratios can be of diagnostic value too. Noted here is that according to a recent investigation of 21 patients suspected of mitochondrial disorder, MRS lactate can be observed in large single voxels centred on the lateral ventricles, in levels that correlate with lactate CSF concentrations [ 29 ]. Further, it can be relevant to localize the MRS in the cerebellum, especially if cerebellar ataxia is the clinical symptom [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of MRS-quantified brain tissue lactate level in identifying children with mitochondrial disorders

et al. 2016

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ObjectivesMagnetic resonance spectroscopy (MRS) of children with or without neurometabolic disease is used for the first time for quantitative assessment of brain tissue lactate signals, to elaborate on previous suggestions of MRS-detected lactate as a marker of mitochondrial disease.MethodsMultivoxel MRS of a transverse plane of brain tissue cranial to the ventricles was performed in 88 children suspected of having neurometabolic disease, divided into ‘definite’ (n = 17, ≥1 major criteria), ‘probable’ (n = 10, ≥2 minor criteria), ‘possible’ (n = 17, 1 minor criterion) and ‘unlikely’ mitochondrial disease (n = 44, none of the criteria). Lactate levels, expressed in standardized arbitrary units or relative to creatine, were derived from summed signals from all voxels. Ten ‘unlikely’ children with a normal neurological exam served as the MRS reference subgroup. For 61 of 88 children, CSF lactate values were obtained.ResultsMRS lactate level (>12 arbitrary units) and the lactate-to-creatine ratio (L/Cr >0.22) differed significantly between the definite and the unlikely group (p = 0.015 and p = 0.001, respectively). MRS L/Cr also differentiated between the probable and the MRS reference subgroup (p = 0.03). No significant group differences were found for CSF lactate.ConclusionMRS-quantified brain tissue lactate levels can serve as diagnostic marker for identifying mitochondrial disease in children.Key points• MRS-detected brain tissue lactate levels can be quantified.• MRS lactate and lactate/Cr are increased in children with mitochondrial disease.• CSF lactate is less suitable as marker of mitochondrial disease.

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Exploring mitochondrial blood-based and genetic markers in older adults with mild cognitive impairment and remitted major depressive disorder

Choi,

Beroncal,

Chernega

et al. 2024

Transl Psychiatry

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Mild cognitive impairment (MCI) is a prodromal stage in aging to possible progression to Alzheimer’s disease and related dementia (ADRD), where co-occurrence of major depressive disorder (MDD) accelerates the progression. Metabolic and mitochondrial abnormalities in ADRD and other neurodegenerative disorders have been widely suggested, while possible mitochondrial dysfunction has been associated with etiopathology of both MCI and MDD. Hence, investigation of mitochondrial markers in MCI, MDD, and presence of both conditions is warranted. In total, 332 older adult participants were included: 168 with MCI, 108 with MCI plus remitted MDD (rMDD), and 56 with rMDD but without MCI. We measured plasma circulating mitochondrial DNA (ccf-mtDNA), lactate, and extracted nuclear mitochondrial encoded (NMt) single-nucleotide variants (SNVs) ( n = 312). Non-parametric statistical tests on ccf-mtDNA and lactate levels were performed on the diagnosis, clinical and cardiometabolic variables. Binary sequence kernel association test (SKAT-O) and burden test were performed on NMt-SNV, adjusted for age, race, gender, type II diabetes, and APOE genotype. Lower level of lactate was observed in MCI (KW χ 2 = 14.8, P = 0.0024), more specifically, significant differences of lower plasma lactate between MCI only and rMDD, but not between MCI+rMDD and MCI were found, suggesting potential roles in MCI driving lactate lower levels. While higher levels of ccf-mtDNA were observed in APOE-ε4 carrier ( χ 2 = 5.04, P = 0.05). This relationship was present only in MCI ( P = 0.043) and MCI+rMDD groups ( P = 0.023). No significant nuclear-encoded mitochondrial gene associations were observed with MCI or MDD. The results suggest decreased level of plasma lactate in individuals with MCI and MCI+rMDD, with inverse correlation with ccf-mtDNA, in addition to effect of APOE-ε4 in further increasing ccf-mtDNA specifically in participants with cognitive impairment. These findings contribute to a deeper understanding of the mitochondrial markers in MCI and MDD, warranting further research to explore the precise roles of mitochondrial abnormalities in the development and progression of MCI.

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Does MRS Lactate Peak Correlate with Lactate in the CSF and Blood?

Cited by 3 publications

References 16 publications

Association between cerebrospinal fluid lactate concentration and central nervous system disease in dogs

Association between cerebrospinal fluid lactate concentration and central nervous system disease in dogs

Diagnostic value of MRS-quantified brain tissue lactate level in identifying children with mitochondrial disorders

Exploring mitochondrial blood-based and genetic markers in older adults with mild cognitive impairment and remitted major depressive disorder

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